Guest guest Posted January 31, 2004 Report Share Posted January 31, 2004 A Viral Cure for Type 1 Diabetes : The Diabetic News : TheDiabeticNews.com Home » Diabetic News Archive 16-Jan-2004 A Viral Cure for Type 1 Diabetes January 2004 - Viruses can both cause and prevent autoimmune disease. In order to understand this dualism, Matthias von Herrath and colleagues from the La Jolla Institute for Allergy and Immunology in California exposed prediabetic mice to viral infections. In the January 2 issue of the Journal of Clinical Investigation the authors report that infection with lymphocytic choriomeningitis virus (LCMV) during the prediabetic period completely abolished the diabetic process in two distinct mouse models. This protection against the development of type 1 diabetes correlated with a reduced number of autoaggressive CD8 T cells in pancreatic islets. Increased production of the chemokine CXCL-10 in pancreatic lymph nodes redirected cells of the immune response away from the b cells. Once in the pancreatic lymph node, CD8 lymphocytes underwent increased apoptosis, which was directly dependent on TNF-a and indirectly on IFN-g production. The data indicate that proinflammatory cytokines and chemokines induced by viral infection can influence ongoing autoaggressive processes beneficially at the preclinical stage if produced at the correct time, location, and level. Therefore viruses that do not directly destroy b cells may actually enhance the course of autoimmune diabetes. Source: Journal of Clinical Investigation Printer-Friendly Version Home | About The Diabetic News | Subscribe | Unsubscribe | News Archive Also Visit: Diabetic Gourmet Magazine | Daily Diabetic Recipe Don't miss out on important news! Would you like to receive important diabetes and health related news like this via email? Join tens of thousands of other satisfied readers, subscribe to The Diabetic News using the form below: Your Email Address: More Free Subscriptions Available » Copyright © CAPCO Marketing. All Rights Reserved. of all the things I have lost, I miss my mind the most. Quote Link to comment Share on other sites More sharing options...
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