INFO - TNF inhibitor use and liver toxicity

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Bulletin on the Rheumatic Diseases

Volume 52, Number 8

Hepatotoxicity. Recent FDA postmarketing surveillance unexpectedly revealed

134 spontaneous reports of liver failure associated with TNF inhibitor use

(16,21). In a detailed review of 50 cases (receiving either infliximab or

etanercept), confounding diagnoses or hepatoxin exposure was seen in 43

cases (eg, sepsis, TB, isoniazid use, alcohol, viral hepatitis, GVHD,

hepatotoxic drugs). However, in 7 cases no other cause could be identified

suggesting that TNF inhibitor use may have lead to hepatic failure. In the

clinical trials with infliximab and adalimumab, sporadic 2- to 3-fold liver

function test elevations may have been attributed to the TNF inhibitor.

http://www.arthritis.org/research/Bulletin/Vol52No8/Safety_Concerns.asp

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