RESEARCH - Familial aggregation of SLE, RA, and other AI diseases in 1,177 lupus patients

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Arthritis Rheum. 2005 Apr;52(4):1138-47.

Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis,

and other autoimmune diseases in 1,177 lupus patients from the GLADEL

cohort.

Alarcon-Segovia D, Alarcon-Riquelme ME, Cardiel MH, Caeiro F, Massardo L,

Villa AR, Pons-Estel BA.

University of Uppsala, Uppsala, Sweden.

OBJECTIVE: To determine whether there is familial aggregation of systemic

lupus erythematosus (SLE) and/or other autoimmune diseases in SLE patients

and to identify clinical differences between patients with and those without

familial autoimmunity. METHODS: We interviewed members of the Grupo

Latinoamericano de Estudio del Lupus Eritematoso (GLADEL) inception cohort

of 1,214 SLE patients to ascertain whether they had relatives with SLE

and/or other autoimmune diseases. Identified relatives were studied.

Familial aggregation was tested using reported highest and intermediate

population prevalence data for SLE, rheumatoid arthritis (RA), or all

autoimmune diseases, and studies were performed to identify the genetic

model applicable for SLE. RESULTS: We identified 116 first-, second-, or

third-degree relatives with SLE, 79 with RA, 23 with autoimmune thyroiditis,

3 with scleroderma, 1 with polymyositis, and 16 with other autoimmune

diseases, related to 166 of the 1,177 SLE patients in the GLADEL cohort who

agreed to participate. Forty-two SLE patients had 2 or more relatives with

an autoimmune disease. We found a lambda(sibling) of 5.8 and 29.0 for SLE

and of 3.2-5.3 for RA, when comparing with their reported high or

intermediate population prevalence, respectively. We also found familial

aggregation for autoimmune disease in general (lambda(sibling) = 1.5) and

determined that for SLE, a polygenic additive genetic model, rather than a

multiplicative one, is applicable.

CONCLUSION: In SLE there is familial aggregation of SLE, RA, and autoimmune

disease in general. A polygenic additive model applies for SLE. American

Indian-white Mestizo SLE patients and those with higher socioeconomic level

were more likely to have familial autoimmunity.

PMID: 15818688

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

5818688 & dopt=Abstract

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