RESEARCH - Serum cytokine levels related to fatigue in patients with primary Sjogren's syndrome.

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Ann Rheum Dis. 2004 Oct;63(10):1335-7.

Serum cytokine levels related to multiple dimensions of fatigue in patients

with primary Sjogren's syndrome.

Hartkamp A, Geenen R, Bijl M, Kruize AA, Godaert GL, Derksen RH.

Department of Rheumatology and Clinical Immunology, University Medical

Centre Utrecht, Huispostnummer F02.127, Postbus 85500, 3508 GA Utrecht, The

Netherlands.

OBJECTIVE: To test whether serum levels of selected cytokines relate to

different dimensions of fatigue in patients with primary Sjogren's syndrome

(pSS). METHODS: Sixty female patients with pSS filled out a questionnaire to

assess multiple dimensions of fatigue. Scores were compared with values in a

population based control group (n = 139). Levels of interleukin (IL)1beta,

IL2, IL6, IL10, and tumour necrosis factor alpha were measured in serum with

commercial sandwich ELISAs. The relationship between self reported

dimensions of fatigue and these serum cytokine levels was determined.

RESULTS: Patients with pSS had high scores at all dimensions of fatigue

(p<0.001): general fatigue, physical fatigue, reduced activity, reduced

motivation, and mental fatigue. Fatigue levels were not related to serum

cytokine levels. The incidental finding that reduced motivation was higher

in patients with detectable serum levels of IL10 (p = 0.04) disappeared

after correction for multiple testing.

CONCLUSION: Fatigue is prominent in patients with pSS and involves all

dimensions of fatigue. The findings do not suggest a widespread effect of

circulating cytokines on multiple aspects of fatigue.

PMID: 15361396

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

5361396 & dopt=Abstract

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