Guest guest Posted April 24, 2005 Report Share Posted April 24, 2005 Does anyone (and I'm sure someone does) know what a CCP test is? My rheumologist didn't really explain it. Thanks. Bill Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2005 Report Share Posted April 24, 2005 Bill, the anti-CCP antibody tests measure anticyclic citrullinated peptide antibodies. Since the rheumatoid factor (RF) test is not specific to RA and isn't positive for all people with RA, researchers have been looking for a better test with which to accurately identify people with rheumatoid arthritis. Positive CCP test values have also been linked to more severe disease. ************************* Ann Rheum Dis. 2005 Mar 30; [Epub ahead of print] A Comparison of the Diagnostic Accuracy and Prognostic Value of the First- and Second Anti-Cyclic Citrullinated Peptides Autoantibody (CCP1 and CCP2) Tests for Rheumatoid Arthritis. van Gaalen FA, Visser H, Huizinga TW. LUMC, Netherlands. OBJECTIVES: Anti-citrulline autoantibodies are used for (early) diagnosis and prognosis of rheumatoid arthritis (RA). Anti-citrulline antibodies can be detected using ELISAs containing cyclic, citrullinated peptides (CCP). Currently two generations of anti-CCP ELISAs (CCP1 and CCP2) are used but no data are available to directly compare the two tests. We compared the diagnostic performance and prognostic value of the anti-CCP1 and anti-CCP2 autoantibody tests in a clinical setting. METHODS: Anti-CCP1 and anti-CCP2 antibody test were performed on the same serum samples obtained from 467 early arthritis patients from the Leiden Arthritis Cohort. The sensitivity, specificity, positive predictive value, and negative predictive value for discriminating between RA and non-RA at one-year follow- up were calculated for both tests. RESULTS: were graphically presented using receiver operating characteristic (ROC) curves. Radiological joint damage progression was assessed over a period of four years in patients with RA and used to assess the prognostics values of the CCP tests. Results: At a similar specificity the CCP2 test had a higher sensitivity than the CCP1 test. Both test identified a sub-group of RA patients with an increased rate of joint damage progression. As compared to the anti-CCP1, the anti-CCP2 test identified more patients with an increased rate of joint damage progression and CCP2 was the best predictor in multiple regression analysis. CONCLUSIONS: In terms of both diagnostic and prognostic ability, the CCP2-test was superior to the CCP1 test. PMID: 15800005 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\ ct & list_uids=15800005 & itool=iconabstr **************************** Not an MD I'll tell you where to go! Mayo Clinic in Rochester http://www.mayoclinic.org/rochester s Hopkins Medicine http://www.hopkinsmedicine.org [ ] CCP Test > > > Does anyone (and I'm sure someone does) know what a CCP test is? My > rheumologist didn't really explain it. Thanks. > > > Bill > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2005 Report Share Posted April 24, 2005 Bill, the anti-CCP antibody tests measure anticyclic citrullinated peptide antibodies. Since the rheumatoid factor (RF) test is not specific to RA and isn't positive for all people with RA, researchers have been looking for a better test with which to accurately identify people with rheumatoid arthritis. Positive CCP test values have also been linked to more severe disease. ************************* Ann Rheum Dis. 2005 Mar 30; [Epub ahead of print] A Comparison of the Diagnostic Accuracy and Prognostic Value of the First- and Second Anti-Cyclic Citrullinated Peptides Autoantibody (CCP1 and CCP2) Tests for Rheumatoid Arthritis. van Gaalen FA, Visser H, Huizinga TW. LUMC, Netherlands. OBJECTIVES: Anti-citrulline autoantibodies are used for (early) diagnosis and prognosis of rheumatoid arthritis (RA). Anti-citrulline antibodies can be detected using ELISAs containing cyclic, citrullinated peptides (CCP). Currently two generations of anti-CCP ELISAs (CCP1 and CCP2) are used but no data are available to directly compare the two tests. We compared the diagnostic performance and prognostic value of the anti-CCP1 and anti-CCP2 autoantibody tests in a clinical setting. METHODS: Anti-CCP1 and anti-CCP2 antibody test were performed on the same serum samples obtained from 467 early arthritis patients from the Leiden Arthritis Cohort. The sensitivity, specificity, positive predictive value, and negative predictive value for discriminating between RA and non-RA at one-year follow- up were calculated for both tests. RESULTS: were graphically presented using receiver operating characteristic (ROC) curves. Radiological joint damage progression was assessed over a period of four years in patients with RA and used to assess the prognostics values of the CCP tests. Results: At a similar specificity the CCP2 test had a higher sensitivity than the CCP1 test. Both test identified a sub-group of RA patients with an increased rate of joint damage progression. As compared to the anti-CCP1, the anti-CCP2 test identified more patients with an increased rate of joint damage progression and CCP2 was the best predictor in multiple regression analysis. CONCLUSIONS: In terms of both diagnostic and prognostic ability, the CCP2-test was superior to the CCP1 test. PMID: 15800005 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\ ct & list_uids=15800005 & itool=iconabstr **************************** Not an MD I'll tell you where to go! Mayo Clinic in Rochester http://www.mayoclinic.org/rochester s Hopkins Medicine http://www.hopkinsmedicine.org [ ] CCP Test > > > Does anyone (and I'm sure someone does) know what a CCP test is? My > rheumologist didn't really explain it. Thanks. > > > Bill > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2005 Report Share Posted April 24, 2005 Hi, Bill, Here is a link that I hope will help you with your question: > http://www.medicinenet.com/citrulline_antibody/article.htm Hugs, Joan A. Bill Mathews wrote: > > Does anyone (and I'm sure someone does) know what a CCP test is? My > rheumologist didn't really explain it. Thanks. > > > Bill > > > > > > ------------------------------------------------------------------------ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2005 Report Share Posted April 24, 2005 Thank you Joan. Bill Joan Arnold wrote: > Hi, Bill, > > Here is a link that I hope will help you with your question: > > > http://www.medicinenet.com/citrulline_antibody/article.htm > > > Hugs, > Joan A. > > > Bill Mathews wrote: > > > > > Does anyone (and I'm sure someone does) know what a CCP test is? My > > rheumologist didn't really explain it. Thanks. > > > > > > Bill > > > > > > > > > > > > ------------------------------------------------------------------------ > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2005 Report Share Posted April 24, 2005 Thank you . It was a little confusing to me. Bill wrote: > Bill, the anti-CCP antibody tests measure anticyclic citrullinated peptide > antibodies. Since the rheumatoid factor (RF) test is not specific to > RA and > isn't positive for all people with RA, researchers have been looking for a > better test with which to accurately identify people with rheumatoid > arthritis. Positive CCP test values have also been linked to more severe > disease. > > > ************************* > > Ann Rheum Dis. 2005 Mar 30; [Epub ahead of print] > > > A Comparison of the Diagnostic Accuracy and Prognostic Value of the First- > and Second Anti-Cyclic Citrullinated Peptides Autoantibody (CCP1 and CCP2) > Tests for Rheumatoid Arthritis. > > van Gaalen FA, Visser H, Huizinga TW. > > LUMC, Netherlands. > > OBJECTIVES: Anti-citrulline autoantibodies are used for (early) diagnosis > and prognosis of rheumatoid arthritis (RA). Anti-citrulline antibodies can > be detected using ELISAs containing cyclic, citrullinated peptides (CCP). > Currently two generations of anti-CCP ELISAs (CCP1 and CCP2) are used > but no > data are available to directly compare the two tests. We compared the > diagnostic performance and prognostic value of the anti-CCP1 and anti-CCP2 > autoantibody tests in a clinical setting. METHODS: Anti-CCP1 and anti-CCP2 > antibody test were performed on the same serum samples obtained from 467 > early arthritis patients from the Leiden Arthritis Cohort. The > sensitivity, > specificity, positive predictive value, and negative predictive value for > discriminating between RA and non-RA at one-year follow- up were > calculated > for both tests. RESULTS: were graphically presented using receiver > operating > characteristic (ROC) curves. Radiological joint damage progression was > assessed over a period of four years in patients with RA and used to > assess > the prognostics values of the CCP tests. Results: At a similar specificity > the CCP2 test had a higher sensitivity than the CCP1 test. Both test > identified a sub-group of RA patients with an increased rate of joint > damage > progression. As compared to the anti-CCP1, the anti-CCP2 test identified > more patients with an increased rate of joint damage progression and CCP2 > was the best predictor in multiple regression analysis. > > CONCLUSIONS: In terms of both diagnostic and prognostic ability, the > CCP2-test was superior to the CCP1 test. > > PMID: 15800005 > > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\ ct & list_uids=15800005 & itool=iconabstr > <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstr\ act & list_uids=15800005 & itool=iconabstr> > > **************************** > > > > Not an MD > > I'll tell you where to go! > > Mayo Clinic in Rochester > http://www.mayoclinic.org/rochester > > s Hopkins Medicine > http://www.hopkinsmedicine.org > > > [ ] CCP Test > > > > > > > > Does anyone (and I'm sure someone does) know what a CCP test is? My > > rheumologist didn't really explain it. Thanks. > > > > > > Bill > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2005 Report Share Posted April 24, 2005 You're welcome, Bill. Are you RF positive? Not an MD I'll tell you where to go! Mayo Clinic in Rochester http://www.mayoclinic.org/rochester s Hopkins Medicine http://www.hopkinsmedicine.org Re: [ ] CCP Test > > > Thank you . It was a little confusing to me. > > Bill Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2005 Report Share Posted April 24, 2005 Yes. I was diagnosed with RA back in November, I definitely have all the symptoms. My RF test was extremely out of range back in November. Since then, my old rheumologist left the city and I'm with a new Dr. She decided to run this CCP test on me, which came back " high but within normal limits. " She never really explained that test to me and that quote was the only results in the letter. I'm going back this Wednesday so I guess I will find out then. Thanks again . Bill wrote: > You're welcome, Bill. Are you RF positive? > > > > Not an MD > > I'll tell you where to go! > > Mayo Clinic in Rochester > http://www.mayoclinic.org/rochester > > s Hopkins Medicine > http://www.hopkinsmedicine.org > > > Re: [ ] CCP Test > > > > > > > > Thank you . It was a little confusing to me. > > > > Bill > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2005 Report Share Posted April 24, 2005 You are very welcome, Bill, and I hope that it was helpful. Joan Bill Mathews wrote: > > Thank you Joan. > > Bill > > Joan Arnold wrote: > > > ------------------------------------------------------------------------ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 24, 2005 Report Share Posted April 24, 2005 Hi Bill here is a little information on a CCP test.. *What does the test result mean?* As a rule, test results outside the context of clinical symptoms and signs cannot be judged. Nonetheless, if a patient is positive for both CCP and RF <http://www.labtestsonline.org/understanding/analytes/rheumatoid/glance.html>, it is very likely that they have RA <http://www.labtestsonline.org/understanding/conditions/rheumatoid.html> and it is likely that they may develop a more severe form of the disease. If a patient is positive for CCP but not RF and clinical signs suggest RA, then it is likely that they have early RA or that they will develop RA in the future. If a patient is negative for CCP but has a positive RF, then the clinical symptoms and signs are more vital in determining whether a patient has RA versus some other inflammatory condition. If a patient is negative for both CCP and RF, then it is less likely that they have RA. It must be emphasized, however, that RA is a clinical diagnosis and may be made in the absence of positive autoantibodies. Corinne Bill Mathews wrote: > > Does anyone (and I'm sure someone does) know what a CCP test is? My > rheumologist didn't really explain it. Thanks. > > > Bill > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 25, 2005 Report Share Posted April 25, 2005 Thanks Corrine. That's what I've gleaned from all the things sent over the past day. This group fully rules. Thanks!! Corinne Drover wrote: > > Hi Bill here is a little information on a CCP test.. > > *What does the test result mean?* > As a rule, test results outside the context of clinical symptoms and > signs cannot be judged. Nonetheless, if a patient is positive for both > CCP and RF > <http://www.labtestsonline.org/understanding/analytes/rheumatoid/glance.html>, > > it is very likely that they have RA > <http://www.labtestsonline.org/understanding/conditions/rheumatoid.html> > and it is likely that they may develop a more severe form of the > disease. If a patient is positive for CCP but not RF and clinical signs > suggest RA, then it is likely that they have early RA or that they will > develop RA in the future. > > If a patient is negative for CCP but has a positive RF, then the > clinical symptoms and signs are more vital in determining whether a > patient has RA versus some other inflammatory condition. If a patient is > negative for both CCP and RF, then it is less likely that they have RA. > It must be emphasized, however, that RA is a clinical diagnosis and may > be made in the absence of positive autoantibodies. > > Corinne > > > > > > Bill Mathews wrote: > > > > > Does anyone (and I'm sure someone does) know what a CCP test is? My > > rheumologist didn't really explain it. Thanks. > > > > > > Bill > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 25, 2005 Report Share Posted April 25, 2005 Thanks Corrine. That's what I've gleaned from all the things sent over the past day. This group fully rules. Thanks!! Corinne Drover wrote: > > Hi Bill here is a little information on a CCP test.. > > *What does the test result mean?* > As a rule, test results outside the context of clinical symptoms and > signs cannot be judged. Nonetheless, if a patient is positive for both > CCP and RF > <http://www.labtestsonline.org/understanding/analytes/rheumatoid/glance.html>, > > it is very likely that they have RA > <http://www.labtestsonline.org/understanding/conditions/rheumatoid.html> > and it is likely that they may develop a more severe form of the > disease. If a patient is positive for CCP but not RF and clinical signs > suggest RA, then it is likely that they have early RA or that they will > develop RA in the future. > > If a patient is negative for CCP but has a positive RF, then the > clinical symptoms and signs are more vital in determining whether a > patient has RA versus some other inflammatory condition. If a patient is > negative for both CCP and RF, then it is less likely that they have RA. > It must be emphasized, however, that RA is a clinical diagnosis and may > be made in the absence of positive autoantibodies. > > Corinne > > > > > > Bill Mathews wrote: > > > > > Does anyone (and I'm sure someone does) know what a CCP test is? My > > rheumologist didn't really explain it. Thanks. > > > > > > Bill > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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