Drug Products with Limited Availability-Methotrexate Injection

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Status as of April 2005

Methotrexate Injection

Strength: 25 mg/mL, 1 g powder vials

Comment: Methotrexate injection is in short supply because of

manufacturing delays. American Pharmaceutical Partners has all products

on back order until June 2005. Bedford also has all products on back

order, but expects the 25 mg/mL 2-mL and 4-mL preservative-free

injection by March 23, 2005. Bedford's 25 mg/mL 8-mL and 10-mL

preservative-free injection are on back order until late April 2005.

Mayne has 1 g methotrexate preservative-free lyophilized powder (NDC

66479-0139-29) available. Mayne also has the 25 mg/mL 2-mL injection

with preservative available for direct purchase by hospitals,

pharmacies, and physician's offices (1-866-594-8420). The company will

not be shipping any methotrexate to wholesalers. All other

presentations, including the 20 mg preservative-free lyophilized

powder, are unavailable and Mayne cannot estimate a release date.

(03/18/05, University of Utah, Drug Information Service)

http://www.ashp.org/shortage/availability-notices.cfm?

cfid=15738752 & CFToken=78062384

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