Guest guest Posted November 14, 2002 Report Share Posted November 14, 2002 Dear Marcelo NSaids are like salicylates, in that they are excreted via kidneys. The Facts and Comparisons says that co-administration of Salicylates with sulfonylureas may cause an increased hypoglycemic effect. This can be more than the desired amount. Therefore this can be a problem if the pt becomes hypoglycemic. In addition the co - administration of salicylates ( must like NSAIDS) may inhibit renal excretion, leading to an increase in blood levels of glypizide. This would then lead to more hypoglycemic effect and this againi is not a good thing. One thing to consider is plasma protein binding that is ionic, such as warfarin or other antiplatlet drugs. NSaids are antiplatelet and bind to such proteins that are ionicaly bound. Since glypizide binds to blood protein, such as albumin by ionic bindings and so do salicylates and NSAIDS there will be competition for this binding. In most cases the NSAID would 'win' the binding with the protein. This would leave more glypizide 'free' or unbound to do more work. The work of glypizide is to be hypoglycemic or to lower blood sugar. This means the effect of the glypizide would be greater. This means the blood glucose would be lowered even more than expected or desired. The patient would become hypoglycemic, which is NOT a good thing. Another thing to consider is the fact that glypizide should be given at least 30 minutes before food as food slows the absorption. But Nsaids must be taken on a full stomach.So if a pt is not proplerly counseled a pt could take these drugs together at one time, either a) before food causing ulcers, but good absorption for glypizide, or after food no ulcers from the nsaid, but good absorption and action for the sulfonylurea/glypizide The simple answer is use of NSAIDS with glypizide leads to increased hypoglycemic effect; which can be caused by decreased excretion via kidneys or decreased proteing binding/increased blood levels. NSAIDS with glypizide may also cause absorption and GI problems. Hope this helps you. Respectfully, Jeanetta Mastron CPhT BS Chemistry > Coadministration of glipizide and which of the following may produce an > unwanted result? > > 1. TCN > 2. PCN. > 3. NSAIDS > 4. DPH > > I know the answer is 3. NSAIDS, but I don't know exactly what the > reasoning is. > > Can anyone explain? > > Thanks, > Marcelo > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 5, 2004 Report Share Posted October 5, 2004 I took Sulindac it was ok. I didn't get much relief from it but I had no adverse stomach problems either. I have an incredibly sensitive stomach and dont remember having any problems with that med. I hope it works out. (poly JRA and SPondy, 19) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 6, 2004 Report Share Posted October 6, 2004 Carolyn, My daughter also takes Sulindac, which is the generic name for Clinoril. She took ibuprofen for many years but we needed to make a switch. She tried others, including naprosyn, but her stomach couldn't handle any of the others we tried. The Sulindac has not given her any trouble at all, but she does continue to take stomach meds with it. She took Zantac for many years but now takes protonix. Liz (-12-poly) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2005 Report Share Posted March 23, 2005 Jessy, I'm glad you're having a nice day. Spring is here! Please talk to your doctor about going off of Prednisone. It must be tapered under a doctor's care. How it is done depends on how long you've been on them and at what dose. When you're on steroids long term, your body stops producing it's own steroids. As you decrease your prednisone, your body is forced to make it's own. This is why it is important to slowly decrease your dose. Increased pain with each decrease in dose is the worst of the side effects. Hopefully your doctor will adjust your pain medication to help with the weaning. If you can wean yourself off prednisone, in the long term you will do yourself a big favor since the long term side effects are so serious. Hair loss is also a listed side effect of MTX. Some people have reported thinning of hair, while others have had no noticeable hair loss. a a On Mar 23, 2005, at 1:13 PM, Jex wrote: > > Morning to All!!! > > It is almost up to 50 degrees here in MN. A good day > and spring is coming!! I had a questions on what side > effects will I see when going off Prednisone? > > Also I am on Methotrexate, is a side effect hair loss? > > > Talk later, > Jessy > > __________________________________________________ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2005 Report Share Posted March 23, 2005 Jessy, I'm glad you're having a nice day. Spring is here! Please talk to your doctor about going off of Prednisone. It must be tapered under a doctor's care. How it is done depends on how long you've been on them and at what dose. When you're on steroids long term, your body stops producing it's own steroids. As you decrease your prednisone, your body is forced to make it's own. This is why it is important to slowly decrease your dose. Increased pain with each decrease in dose is the worst of the side effects. Hopefully your doctor will adjust your pain medication to help with the weaning. If you can wean yourself off prednisone, in the long term you will do yourself a big favor since the long term side effects are so serious. Hair loss is also a listed side effect of MTX. Some people have reported thinning of hair, while others have had no noticeable hair loss. a a On Mar 23, 2005, at 1:13 PM, Jex wrote: > > Morning to All!!! > > It is almost up to 50 degrees here in MN. A good day > and spring is coming!! I had a questions on what side > effects will I see when going off Prednisone? > > Also I am on Methotrexate, is a side effect hair loss? > > > Talk later, > Jessy > > __________________________________________________ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2005 Report Share Posted March 23, 2005 Hi Jessy. I had been slowly tapered off of Prednisone after using it for only 4 weeks, and suffered a terrible flare up. I had become more ill than I was prior to even starting to take it. I was put back on Prednisone again at a lower dose, and am once again being tapered off of it at a much slower rate. I have flared up again and with each decrease in my dose, I feel more pain and less mobility. I am sticking it out in hopes that I can get off of it for good. The weight gain I have had since starting Prednisone 2 months ago has caused me to feel depressed and I'm sure it's not good for my joints either. While I'm grateful for the relief that Prednisone provided me with, I am frustrated with the side effects and how dependent my body has become to it. > > Morning to All!!! > > It is almost up to 50 degrees here in MN. A good day > and spring is coming!! I had a questions on what side > effects will I see when going off Prednisone? > > Also I am on Methotrexate, is a side effect hair loss? > > > Talk later, > Jessy > > __________________________________________________ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2005 Report Share Posted March 23, 2005 Hi Jessy. I had been slowly tapered off of Prednisone after using it for only 4 weeks, and suffered a terrible flare up. I had become more ill than I was prior to even starting to take it. I was put back on Prednisone again at a lower dose, and am once again being tapered off of it at a much slower rate. I have flared up again and with each decrease in my dose, I feel more pain and less mobility. I am sticking it out in hopes that I can get off of it for good. The weight gain I have had since starting Prednisone 2 months ago has caused me to feel depressed and I'm sure it's not good for my joints either. While I'm grateful for the relief that Prednisone provided me with, I am frustrated with the side effects and how dependent my body has become to it. > > Morning to All!!! > > It is almost up to 50 degrees here in MN. A good day > and spring is coming!! I had a questions on what side > effects will I see when going off Prednisone? > > Also I am on Methotrexate, is a side effect hair loss? > > > Talk later, > Jessy > > __________________________________________________ > Quote Link to comment Share on other sites More sharing options...
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