The COX-2 dilemma: Risking heart problems to ease pain

March 2, 2005

http://www.usatoday.com/news/health/2005-03-02-cox-2_x.htm

March 3, 2005

These COX-2 articles make for interesting reading.

The woman who isn't concerned about Bextra making her ankles swell should

be.

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[ ] The COX-2 dilemma: Risking heart problems to ease pain

>

> The COX-2 dilemma: Risking heart problems to ease pain

>

> http://www.usatoday.com/news/health/2005-03-02-cox-2_x.htm

March 3, 2005

How right you are. There are many people that can take the 2's

without a problem, but she is one that is ignoring obvious symptoms.

When my blood pressure increased while on Vioxx, I took it seriously

and quit taking it even though my doctor poo pood my concern.

The one good thing that is coming out of this is that doctors won't be

prescribing them as much. Instead of a first resort, they will be a

last resort.

a

On Thu, 3 Mar 2005 07:04:18 -0600, <Matsumura_Clan@...> wrote:

> These COX-2 articles make for interesting reading.

>

> The woman who isn't concerned about Bextra making her ankles swell should

> be.

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

>

> [ ] The COX-2 dilemma: Risking heart problems to ease

> pain

>

> >

> > The COX-2 dilemma: Risking heart problems to ease pain

> >

> > http://www.usatoday.com/news/health/2005-03-02-cox-2_x.htm

>

March 3, 2005

How right you are. There are many people that can take the 2's

without a problem, but she is one that is ignoring obvious symptoms.

When my blood pressure increased while on Vioxx, I took it seriously

and quit taking it even though my doctor poo pood my concern.

The one good thing that is coming out of this is that doctors won't be

prescribing them as much. Instead of a first resort, they will be a

last resort.

a

On Thu, 3 Mar 2005 07:04:18 -0600, <Matsumura_Clan@...> wrote:

> These COX-2 articles make for interesting reading.

>

> The woman who isn't concerned about Bextra making her ankles swell should

> be.

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

>

> [ ] The COX-2 dilemma: Risking heart problems to ease

> pain

>

> >

> > The COX-2 dilemma: Risking heart problems to ease pain

> >

> > http://www.usatoday.com/news/health/2005-03-02-cox-2_x.htm

>

March 3, 2005

Hi a,

I remember when I was on Vioxx and my blood pressure shot through the

roof, it was you who alerted me to the vioxx/blood pressure thing. Like

you my doctors didn't believe me. But I took your advise and the warning

and got off of it. I will always be grateful to you for your help. It

would have been nice if I could have taken the drug. But we all need to be

alert to side effects and make the doctors listen. All drugs are not for

everyone.

Lynn MeMom

Original Message:

-----------------

From: a papola@...

Date: Thu, 3 Mar 2005 08:22:24 -0500

Subject: Re: [ ] The COX-2 dilemma: Risking heart problems to ease

pain

How right you are. There are many people that can take the 2's

without a problem, but she is one that is ignoring obvious symptoms.

When my blood pressure increased while on Vioxx, I took it seriously

and quit taking it even though my doctor poo pood my concern.

The one good thing that is coming out of this is that doctors won't be

prescribing them as much. Instead of a first resort, they will be a

last resort.

a

On Thu, 3 Mar 2005 07:04:18 -0600, <Matsumura_Clan@...>

wrote:

> These COX-2 articles make for interesting reading.

>

> The woman who isn't concerned about Bextra making her ankles swell

should

> be.

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

>

> [ ] The COX-2 dilemma: Risking heart problems to ease

> pain

>

> >

> > The COX-2 dilemma: Risking heart problems to ease pain

> >

> > http://www.usatoday.com/news/health/2005-03-02-cox-2_x.htm

>

March 3, 2005

Hi a,

I remember when I was on Vioxx and my blood pressure shot through the

roof, it was you who alerted me to the vioxx/blood pressure thing. Like

you my doctors didn't believe me. But I took your advise and the warning

and got off of it. I will always be grateful to you for your help. It

would have been nice if I could have taken the drug. But we all need to be

alert to side effects and make the doctors listen. All drugs are not for

everyone.

Lynn MeMom

Original Message:

-----------------

From: a papola@...

Date: Thu, 3 Mar 2005 08:22:24 -0500

Subject: Re: [ ] The COX-2 dilemma: Risking heart problems to ease

pain

How right you are. There are many people that can take the 2's

without a problem, but she is one that is ignoring obvious symptoms.

When my blood pressure increased while on Vioxx, I took it seriously

and quit taking it even though my doctor poo pood my concern.

The one good thing that is coming out of this is that doctors won't be

prescribing them as much. Instead of a first resort, they will be a

last resort.

a

On Thu, 3 Mar 2005 07:04:18 -0600, <Matsumura_Clan@...>

wrote:

> These COX-2 articles make for interesting reading.

>

> The woman who isn't concerned about Bextra making her ankles swell

should

> be.

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

>

> [ ] The COX-2 dilemma: Risking heart problems to ease

> pain

>

> >

> > The COX-2 dilemma: Risking heart problems to ease pain

> >

> > http://www.usatoday.com/news/health/2005-03-02-cox-2_x.htm

>

March 3, 2005

I wish I could have stayed on it too Lynn. It really did help the

pain. I'm glad we don't have to add cardiac problems to our list!

Also glad the information on this list is helpful.

a

On Thu, 3 Mar 2005 08:30:20 -0500, ruf-caimi@...

<ruf-caimi@...> wrote:

> Hi a,

> I remember when I was on Vioxx and my blood pressure shot through the

> roof, it was you who alerted me to the vioxx/blood pressure thing. Like

> you my doctors didn't believe me. But I took your advise and the warning

> and got off of it. I will always be grateful to you for your help. It

> would have been nice if I could have taken the drug. But we all need to be

> alert to side effects and make the doctors listen. All drugs are not for

> everyone.

> Lynn MeMom

>

> Original Message:

> -----------------

> From: a papola@...

> Date: Thu, 3 Mar 2005 08:22:24 -0500

>

> Subject: Re: [ ] The COX-2 dilemma: Risking heart problems to ease

>

> pain

>

> How right you are. There are many people that can take the 2's

> without a problem, but she is one that is ignoring obvious symptoms.

> When my blood pressure increased while on Vioxx, I took it seriously

> and quit taking it even though my doctor poo pood my concern.

> The one good thing that is coming out of this is that doctors won't be

> prescribing them as much. Instead of a first resort, they will be a

> last resort.

> a

>

> On Thu, 3 Mar 2005 07:04:18 -0600, <Matsumura_Clan@...>

> wrote:

> > These COX-2 articles make for interesting reading.

> >

> > The woman who isn't concerned about Bextra making her ankles swell

> should

> > be.

> >

> > I'll tell you where to go!

> >

> > Mayo Clinic in Rochester

> > http://www.mayoclinic.org/rochester

> >

> > s Hopkins Medicine

> > http://www.hopkinsmedicine.org

> >

> > [ ] The COX-2 dilemma: Risking heart problems to ease

> > pain

> >

> > >

> > > The COX-2 dilemma: Risking heart problems to ease pain

> > >

> > > http://www.usatoday.com/news/health/2005-03-02-cox-2_x.htm

> >

March 3, 2005

I wish I could have stayed on it too Lynn. It really did help the

pain. I'm glad we don't have to add cardiac problems to our list!

Also glad the information on this list is helpful.

a

On Thu, 3 Mar 2005 08:30:20 -0500, ruf-caimi@...

<ruf-caimi@...> wrote:

> Hi a,

> I remember when I was on Vioxx and my blood pressure shot through the

> roof, it was you who alerted me to the vioxx/blood pressure thing. Like

> you my doctors didn't believe me. But I took your advise and the warning

> and got off of it. I will always be grateful to you for your help. It

> would have been nice if I could have taken the drug. But we all need to be

> alert to side effects and make the doctors listen. All drugs are not for

> everyone.

> Lynn MeMom

>

> Original Message:

> -----------------

> From: a papola@...

> Date: Thu, 3 Mar 2005 08:22:24 -0500

>

> Subject: Re: [ ] The COX-2 dilemma: Risking heart problems to ease

>

> pain

>

> How right you are. There are many people that can take the 2's

> without a problem, but she is one that is ignoring obvious symptoms.

> When my blood pressure increased while on Vioxx, I took it seriously

> and quit taking it even though my doctor poo pood my concern.

> The one good thing that is coming out of this is that doctors won't be

> prescribing them as much. Instead of a first resort, they will be a

> last resort.

> a

>

> On Thu, 3 Mar 2005 07:04:18 -0600, <Matsumura_Clan@...>

> wrote:

> > These COX-2 articles make for interesting reading.

> >

> > The woman who isn't concerned about Bextra making her ankles swell

> should

> > be.

> >

> > I'll tell you where to go!

> >

> > Mayo Clinic in Rochester

> > http://www.mayoclinic.org/rochester

> >

> > s Hopkins Medicine

> > http://www.hopkinsmedicine.org

> >

> > [ ] The COX-2 dilemma: Risking heart problems to ease

> > pain

> >

> > >

> > > The COX-2 dilemma: Risking heart problems to ease pain

> > >

> > > http://www.usatoday.com/news/health/2005-03-02-cox-2_x.htm

> >

March 3, 2005

a,

If they could accurately identify groups who were the most likely to be

adversely affected (which they can't since our ADR reporting system is a

woefully inadequate mishmash of ineffective, nearly meaningless

repositories), the worry wouldn't be as great.

Some people can take them safely, but who? Do we really want to be playing

Russian roulette? Trade a heart attack or stroke for a GI bleed?

Furthermore, only Vioxx has been demonstrated to have an association with

significantly fewer (through not a whopping difference) GI problems.

Doctors better wake up and realize that the adverse events listed by the

pharmaceutical companies as a result of their trials (which are carefully

designed to include patients who are not likely to make the data look bad)

are only a starting point. Why your physician wouldn't listen to you, a very

well informed patient, and investigate the sudden increase in BP is a

mystery. Maybe it's an outrage!

I'll stop writing now since my blood pressure is rising as I type. I think

as soon as the kids are on their own, I'm going to apply for work at Public

Citizen.

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

Re: [ ] The COX-2 dilemma: Risking heart problems to ease

pain

>

> How right you are. There are many people that can take the 2's

> without a problem, but she is one that is ignoring obvious symptoms.

> When my blood pressure increased while on Vioxx, I took it seriously

> and quit taking it even though my doctor poo pood my concern.

> The one good thing that is coming out of this is that doctors won't be

> prescribing them as much. Instead of a first resort, they will be a

> last resort.

> a

March 3, 2005