Guest guest Posted July 29, 2004 Report Share Posted July 29, 2004 There is a very good article in January's edition of New Pathways on one women's remarkable recovery when she took a histamine product for vertigo. The article goes on to talk about prokarin and why it might work. My question is whether anybody has had any success with prokarin? When I look at the list of things that histamine does it makes me think I should start taking it, particularly its ability to reduce heat sensitivity. ne http://www.msrc.co.uk/downloads/npwm_2004_0023.pdf How Does Histamine Work in MS? Scientists at The Tahoma Clinic have come up with a hypothesis of how histamine might be working in MS. MS patients have a deficiency of histamine, a neurotransmitter. Histamine is the most potent stimulator of the cells which produce myelin - oligodendrocytes. Oligodentrocytes degenerate in the absence of histamine, leading to myelin damage. They become active in producing myelin again when histamine is re-introduced. Our bodies need histamine in order to maintain these myelin-producing cells. MS fatigue can be explained by a lack of histamine. When there is a deficiency of histamine, the body breaks down its energy molecules ATP to produce histamine. Histamine is the heat stress regulator. Without enough histamine, the MS patient becomes very sensitive to heat and MS symptoms worsen. Histamine is also a very important stress modulator for the body. The more stress someone experiences, the more histamine is required. If you are lacking in histamine, you won't be able to completely digest fat and protein. Studies show that MS patients have undigested protein and fat in their stools. Histamine stimulates the secretion of gastric enzymes that digest these foods. Histamine also stimulates the secretion of the intrinsic factor, which is necessary for the absorption of vitamin B12 from the intestines. MS patients often have low levels of vitamin B12 in the cerebro spinal fluid and enlarged red blood cells, which are a sign of B12 deficiency. This may be due to lack of histamine, needed to bind vitamin B12 to a carrier molecule in the liver. Abnormal integrity and permeability of the blood brain barrier in MS may be due to a lack of histamine. Histamine also stimulates the production of melatonin and serotonin. MS patients have an abnormally low level of melatonin due to a lack of histamine. In MS, a virus may be responsible for attacking histamine-producing cells. It tricks these cells into reproducing itself. The cells become busy making the virus rather than making histamine. Once histamine is depleted to the point that the body can no longer produce enough to maintain myelin as well as its many other functions, MS symptoms begin to worsen. How Histamine Helps MS Symptoms .. Reduces fatigue .. Improves walking .. Reduces heat sensitivity .. Improves energy .. Improves mood .. Decreases tingling and numbness .. Decreases tremor and spasticity .. Improves co-ordination .. Improves digestion and absorption .. Improves constipation .. Improves urinary urgency .. Improves speech .. Improves activities of daily living Improvements are often seen within a few hours or days of starting therapy. Side effects are minimal. Other Ways Of Taking Histamine Being stung by bees or stinging nettles raises levels of histamine. This is how bee sting therapy may be working in MS. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 29, 2004 Report Share Posted July 29, 2004 ne I almost missed the bottom line: Being stung by bees or stinging nettles raises levels of histamine. This is how bee sting therapy may be working in MS. Interesting. As you probably know high amounts of B3 as niacin (has to be niacin) causes histamine release. This may be good, or it may deplete your stores of histamine. I really have no idea. Szpak > There is a very good article in January's edition of New Pathways on one > women's remarkable recovery when she took a histamine product for vertigo. > The article goes on to talk about prokarin and why it might work. My > question is whether anybody has had any success with prokarin? When I look > at the list of things that histamine does it makes me think I should start > taking it, particularly its ability to reduce heat sensitivity. > ne > http://www.msrc.co.uk/downloads/npwm_2004_0023.pdf > How Does Histamine > Work in MS? > Scientists at The Tahoma Clinic > have come up with a hypothesis > of how histamine might be > working in MS. > MS patients have a deficiency > of histamine, a neurotransmitter. > Histamine is the most potent > stimulator of the cells which > produce myelin - > oligodendrocytes. > Oligodentrocytes degenerate > in the absence of histamine, > leading to myelin damage. They > become active in producing > myelin again when histamine is > re-introduced. Our bodies need > histamine in order to maintain > these myelin-producing cells. > MS fatigue can be explained > by a lack of histamine. When > there is a deficiency of > histamine, the body breaks > down its energy molecules ATP > to produce histamine. > Histamine is the heat stress > regulator. Without enough > histamine, the MS patient > becomes very sensitive to heat > and MS symptoms worsen. > Histamine is also a very > important stress modulator for > the body. The more stress > someone experiences, the more > histamine is required. > If you are lacking in > histamine, you won't be able to > completely digest fat and > protein. Studies show that MS > patients have undigested > protein and fat in their stools. > Histamine stimulates the > secretion of gastric enzymes > that digest these foods. > Histamine also stimulates > the secretion of the intrinsic > factor, which is necessary for > the absorption of vitamin B12 > from the intestines. > MS patients often have low > levels of vitamin B12 in the > cerebro spinal fluid and > enlarged red blood cells, which > are a sign of B12 deficiency. > This may be due to lack of > histamine, needed to bind > vitamin B12 to a carrier > molecule in the liver. > Abnormal integrity and > permeability of the blood brain > barrier in MS may be due to a > lack of histamine. > Histamine also stimulates > the production of melatonin > and serotonin. MS patients > have an abnormally low level of > melatonin due to a lack of > histamine. > In MS, a virus may be > responsible for attacking > histamine-producing cells. It > tricks these cells into > reproducing itself. The cells > become busy making the virus > rather than making histamine. > Once histamine is depleted > to the point that the body can > no longer produce enough to > maintain myelin as well as its > many other functions, MS > symptoms begin to worsen. > How Histamine Helps > MS Symptoms > . Reduces fatigue > . Improves walking > . Reduces heat sensitivity > . Improves energy > . Improves mood > . Decreases tingling and > numbness > . Decreases tremor and > spasticity > . Improves co-ordination > . Improves digestion and > absorption > . Improves constipation > . Improves urinary urgency > . Improves speech > . Improves activities of daily > living > Improvements are often seen > within a few hours or days of > starting therapy. Side effects > are minimal. > Other Ways Of Taking > Histamine > Being stung by bees or stinging > nettles raises levels of > histamine. This is how bee sting > therapy may be working in MS. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 2, 2004 Report Share Posted August 2, 2004 ne I came across this by accident tonight. You've probably seen it already. http://www.goodshape.net/ Anyway, did you consider or understand why I mentioned taking high doses of niacin to cause a histamine release? > There is a very good article in January's edition of New Pathways on one > women's remarkable recovery when she took a histamine product for vertigo. > The article goes on to talk about prokarin and why it might work. My > question is whether anybody has had any success with prokarin? When I look > at the list of things that histamine does it makes me think I should start > taking it, particularly its ability to reduce heat sensitivity. > ne > http://www.msrc.co.uk/downloads/npwm_2004_0023.pdf > How Does Histamine > Work in MS? > Scientists at The Tahoma Clinic > have come up with a hypothesis > of how histamine might be > working in MS. > MS patients have a deficiency > of histamine, a neurotransmitter. > Histamine is the most potent > stimulator of the cells which > produce myelin - > oligodendrocytes. > Oligodentrocytes degenerate > in the absence of histamine, > leading to myelin damage. They > become active in producing > myelin again when histamine is > re-introduced. Our bodies need > histamine in order to maintain > these myelin-producing cells. > MS fatigue can be explained > by a lack of histamine. When > there is a deficiency of > histamine, the body breaks > down its energy molecules ATP > to produce histamine. > Histamine is the heat stress > regulator. Without enough > histamine, the MS patient > becomes very sensitive to heat > and MS symptoms worsen. > Histamine is also a very > important stress modulator for > the body. The more stress > someone experiences, the more > histamine is required. > If you are lacking in > histamine, you won't be able to > completely digest fat and > protein. Studies show that MS > patients have undigested > protein and fat in their stools. > Histamine stimulates the > secretion of gastric enzymes > that digest these foods. > Histamine also stimulates > the secretion of the intrinsic > factor, which is necessary for > the absorption of vitamin B12 > from the intestines. > MS patients often have low > levels of vitamin B12 in the > cerebro spinal fluid and > enlarged red blood cells, which > are a sign of B12 deficiency. > This may be due to lack of > histamine, needed to bind > vitamin B12 to a carrier > molecule in the liver. > Abnormal integrity and > permeability of the blood brain > barrier in MS may be due to a > lack of histamine. > Histamine also stimulates > the production of melatonin > and serotonin. MS patients > have an abnormally low level of > melatonin due to a lack of > histamine. > In MS, a virus may be > responsible for attacking > histamine-producing cells. It > tricks these cells into > reproducing itself. The cells > become busy making the virus > rather than making histamine. > Once histamine is depleted > to the point that the body can > no longer produce enough to > maintain myelin as well as its > many other functions, MS > symptoms begin to worsen. > How Histamine Helps > MS Symptoms > . Reduces fatigue > . Improves walking > . Reduces heat sensitivity > . Improves energy > . Improves mood > . Decreases tingling and > numbness > . Decreases tremor and > spasticity > . Improves co-ordination > . Improves digestion and > absorption > . Improves constipation > . Improves urinary urgency > . Improves speech > . Improves activities of daily > living > Improvements are often seen > within a few hours or days of > starting therapy. Side effects > are minimal. > Other Ways Of Taking > Histamine > Being stung by bees or stinging > nettles raises levels of > histamine. This is how bee sting > therapy may be working in MS. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 5, 2004 Report Share Posted August 5, 2004 Histidine is required for Histidine is also a precursor of histamine, a compound released by immune system cells during an allergic reaction. It is needed for growth and for the repair of tissue, as well as the maintenance of the myelin sheaths that act as protector for nerve cells. It is further required for the manufacture of both red and white blood cells, and helps to protect the body from damage caused by radiation and in removing heavy metals from the body. In the stomach, histidine is also helpful in producing gastric juices, and people with a shortage of gastric juices or suffering from indigestion, may also benefit from this nutrient. Deficiency of histidine None known, but it is reported that an increase in the intake of this nutrient helps with the lengthening of orgasms and also more intense sexual enjoyment. Some people take 1,000 mg of histidine two to three times per day in capsule or tablet form but it is best to work out the dosage requirements as 8-10 mg per day per kilogram of body weight. Toxicity and symptoms of high intake There are no reported side effects with histidine, but too high levels of histidine may lead to stress and mental disorders such as anxiety and people with schizophrenia have been found to have high levels of histidine. People suffering from schizophrenia or bipolar (manic) depression should not take a histidine supplement without the approval of their medical professional. Best used with Best taken with _vitamin B3_ (http://www.anyvitamins.com/vitamin-b3-niacin-info.htm) (_niacin_ (http://www.anyvitamins.com/vitamin-b3-niacin-info.htm) ) and B6 (_pyridoxine_ (http://www.anyvitamins.com/vitamin-b6-pyridoxine-info.htm) ). When more may be required Although not conclusively proven – it is thought that histidine may be beneficial to people suffering from arthritis and nerve deafness. Other interesting points Histidine is also used for sexual arousal, functioning and enjoyment Histidinemia is an inborn error of the metabolism of histidine due to a deficiency of the enzyme histidase, where high levels of histidine are found in the blood and urine, and may manifest in speech disorders and mental retardation. Food sources of histidine Dairy, meat, poultry and fish are good sources of histidine as well as rice, wheat and rye. Jeff el _http://www.msprotocols.netfirms.com/_ (http://www.msprotocols.netfirms.com/) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 20, 2004 Report Share Posted September 20, 2004 , Next time you send an e-mail to the group could you please delete all but the relevant information from your e-mail? Some people who get digests are overwhelmed with the amount of mail they get. If you would like to know more about histamine, go to www.goodshape.net - it tells you how to make it and the experience of other people taking it. I have no idea why it works but it, along with other treatments like bee stinging, have been around long enough to make me think there is something to it. Folks at the Tahoma clinic are doing research in this area: http://www.tahoma-clinic.com/ ne Re: Digest Number 1537 I am writing about histamine. This is an older post about histamine and MS; what do you all make of it? Has there been any other research with histamine and the blood-brain barrier? I just was at UCLA yesterday, and the MS neurologist told me that my blood brain barrier was not compromised as none of my lesions on my brain enhanced with contrast. Here goes the post . . . Scientists at Emory University School of Medicine have uncovered a significant connection between mast cells -- a type of immune cell -- and the development of multiple sclerosis, an auto-immune disease that attacks the central nervous system. Until now, research into the mechanisms of multiple sclerosis (MS) has been focused almost exclusively on errant responses by immune T cells that attack the body's own tissues. What's Related Fluorescent Signaling By Immune Cells UBC Researcher Discovers 'Control Room' That Regulates Immune Responses Understanding How Lymph Nodes Respond To Infection May Redefine How Immune System Functions > more related stories --------------------------------- Related section: Health & Medicine Quote Link to comment Share on other sites More sharing options...
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