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instructions from Labcorp RE: how to collect specimen from heterosexual men for HPV testing?

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2 ways to do Male HPV

1-Test #550020 swab male urethra and place into Thinprep or HPV vial. Can use brush but need to make sure there are adequate amount of cells to get a result.

2-Test# 550020 HPV collected Anal using swab, or brush and placed into ThinPrep vial or HPV vial.

*something to note- HPV test is not FDA approved on males so will come with a disclaimer. B/c it could be considered investigational, insurance

may or may not cover.

Another option- but more invasive is to biopsy infected area in question and place in formalin jar and order test code#500199

Question: Is it realistic to use the Papsmear brush to collect cells from the uretha?HelenTo: From: qualityfp@...Date: Wed, 1 Feb 2012 14:43:58 -0500Subject: RE: how to collect specimen from heterosexual men for HPV testing?

You could do a urethral swab. But a negative test won’t mean he is HPV negative. There is no accurate way to test men. You can also soak his penis in vinegar for 20 minutes and look at it with magnification. Any acetowhite areas could be genital warts. But lack of visible acetowhite areas doesn’t mean he doesn’t have it. You simply tell him to use condoms. That there is no visible evidence of HPV but there is no guarantee that he doesn’t have it. Right now there is no test that can definitively say he doesn’t have it and you should just always behave as if you do. Kathy Saradarian, MDBranchville, NJwww.qualityfamilypractice.comSolo 4/03, Practicing since 9/90Practice Partner 5/03Low staffing From: [mailto: ] On Behalf Of Helen YangSent: Wednesday, February 01, 2012 2:35 PMTo: IMP GroupSubject: RE: how to collect specimen from heterosexual men for HPV testing? ,You are correct that there is no FDA approved HPV test for man, but the local Labcorp said they could run the test with the specimen in the Thin Prep solution--as for Pap smear. They could not tell us how to collect the specimen.This patient did not show any signs of wart. He wants to find out about his HPV status before starting a new relationship. He was not interested in any other STD testing.HelenTo: From: glseto@...Date: Wed, 1 Feb 2012 10:59:12 -0800Subject: Re: how to collect specimen from heterosexual men for HPV testing? Helen,According to the CDC, there is no HPV test recommended for males:http://www.cdc.gov/std/hpv/stdfact-hpv-and-men.htm Is there a test for HPV in men?Currently, there is no HPV test recommended for men. The only approved HPV tests on the market are for screening women for cervical cancer. They are not useful for screening for HPV-related cancers or genital warts in men.· Screening for anal cancer is not routinely recommended for men. This is because more research is needed to find out if it can actually prevent anal cancer. However, some experts do recommend yearly anal cancer screening (anal Pap tests) for gay, bisexual, and HIV-positive men – since anal cancer is more common in these men.There is no approved test to find genital warts for men or women. However, most of the time, you can see genital warts. If you think you may have genital warts, you should see a health care provider.There is no test for men to check one’s overall “HPV status.” But HPV usually goes away on its own, without causing health problems. So an HPV infection that is found today will most likely not be there a year or two from now. Screening tests are not available for penile cancer. Even if there was a test for men, how would the results change anything? • If it is positive, but no lesions visible, the patient worries and you give the usual STD prevention advice, but condoms are not foolproof for preventing HPV transmission. • If it is negative, and no lesions visible, the patient feels relieved but you still give the usual STD prevention advice.• If you see genital warts, it doesn't matter what the test results are. You treat appropriately and give the usual STD prevention advice. If he is really worried about HPV, he should consider the HPV vaccine if he is an appropriate candidate. SetoSouth Pasadena, CA A heterosexual male patient requests HPV testing.If we are to collect an anal swab or brush specimen from homosexual patients, where and with what type of swab to collect specimen from heterosexual male? Urethra or just genital skin cells? It wouldn't matter when the patient last showered even if collecting from skin surface, would it?Thank you.Helen

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What are the costs of this HPV test to the patient? And how will the results help him? SetoSouth Pasadena, CA

2 ways to do Male HPV

1-Test #550020 swab male urethra and place into Thinprep or HPV vial. Can use brush but need to make sure there are adequate amount of cells to get a result.

2-Test# 550020 HPV collected Anal using swab, or brush and placed into ThinPrep vial or HPV vial.

*something to note- HPV test is not FDA approved on males so will come with a disclaimer. B/c it could be considered investigational, insurance

may or may not cover.

Another option- but more invasive is to biopsy infected area in question and place in formalin jar and order test code#500199

Question: Is it realistic to use the Papsmear brush to collect cells from the uretha?HelenTo: From: qualityfp@...Date: Wed, 1 Feb 2012 14:43:58 -0500Subject: RE: how to collect specimen from heterosexual men for HPV testing?

You could do a urethral swab. But a negative test won’t mean he is HPV negative. There is no accurate way to test men. You can also soak his penis in vinegar for 20 minutes and look at it with magnification. Any acetowhite areas could be genital warts. But lack of visible acetowhite areas doesn’t mean he doesn’t have it. You simply tell him to use condoms. That there is no visible evidence of HPV but there is no guarantee that he doesn’t have it. Right now there is no test that can definitively say he doesn’t have it and you should just always behave as if you do. Kathy Saradarian, MDBranchville, NJwww.qualityfamilypractice.comSolo 4/03, Practicing since 9/90Practice Partner 5/03Low staffing From: [mailto: ] On Behalf Of Helen YangSent: Wednesday, February 01, 2012 2:35 PMTo: IMP GroupSubject: RE: how to collect specimen from heterosexual men for HPV testing? ,You are correct that there is no FDA approved HPV test for man, but the local Labcorp said they could run the test with the specimen in the Thin Prep solution--as for Pap smear. They could not tell us how to collect the specimen.This patient did not show any signs of wart. He wants to find out about his HPV status before starting a new relationship. He was not interested in any other STD testing.HelenTo: From: glseto@...Date: Wed, 1 Feb 2012 10:59:12 -0800Subject: Re: how to collect specimen from heterosexual men for HPV testing? Helen,According to the CDC, there is no HPV test recommended for males:http://www.cdc.gov/std/hpv/stdfact-hpv-and-men.htm Is there a test for HPV in men?Currently, there is no HPV test recommended for men. The only approved HPV tests on the market are for screening women for cervical cancer. They are not useful for screening for HPV-related cancers or genital warts in men.· Screening for anal cancer is not routinely recommended for men. This is because more research is needed to find out if it can actually prevent anal cancer. However, some experts do recommend yearly anal cancer screening (anal Pap tests) for gay, bisexual, and HIV-positive men – since anal cancer is more common in these men.There is no approved test to find genital warts for men or women. However, most of the time, you can see genital warts. If you think you may have genital warts, you should see a health care provider.There is no test for men to check one’s overall “HPV status.” But HPV usually goes away on its own, without causing health problems. So an HPV infection that is found today will most likely not be there a year or two from now. Screening tests are not available for penile cancer. Even if there was a test for men, how would the results change anything? • If it is positive, but no lesions visible, the patient worries and you give the usual STD prevention advice, but condoms are not foolproof for preventing HPV transmission. • If it is negative, and no lesions visible, the patient feels relieved but you still give the usual STD prevention advice.• If you see genital warts, it doesn't matter what the test results are. You treat appropriately and give the usual STD prevention advice. If he is really worried about HPV, he should consider the HPV vaccine if he is an appropriate candidate. SetoSouth Pasadena, CA A heterosexual male patient requests HPV testing.If we are to collect an anal swab or brush specimen from homosexual patients, where and with what type of swab to collect specimen from heterosexual male? Urethra or just genital skin cells? It wouldn't matter when the patient last showered even if collecting from skin surface, would it?Thank you.Helen

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Bigger question, is it humane? Only reason to do anal swab is if person is engaging in anal receptive intercourse. And again, a negative doesn’t mean no HPV is present. Just means it wasn’t detected at that moment. I think it’s best to explain to the young man why this isn’t done, though it might take longer. Kathy Saradarian, MDBranchville, NJwww.qualityfamilypractice.comSolo 4/03, Practicing since 9/90Practice Partner 5/03Low staffing From: [mailto: ] On Behalf Of Helen YangSent: Thursday, February 02, 2012 9:07 AMTo: IMP GroupSubject: instructions from Labcorp RE: how to collect specimen from heterosexual men for HPV testing? 2 ways to do Male HPV1-Test #550020 swab male urethra and place into Thinprep or HPV vial. Can use brush but need to make sure there are adequate amount of cells to get a result.2-Test# 550020 HPV collected Anal using swab, or brush and placed into ThinPrep vial or HPV vial.*something to note- HPV test is not FDA approved on males so will come with a disclaimer. B/c it could be considered investigational, insurance may or may not cover.Another option- but more invasive is to biopsy infected area in question and place in formalin jar and order test code#500199 Question: Is it realistic to use the Papsmear brush to collect cells from the uretha?HelenTo: From: qualityfp@...Date: Wed, 1 Feb 2012 14:43:58 -0500Subject: RE: how to collect specimen from heterosexual men for HPV testing? You could do a urethral swab. But a negative test won’t mean he is HPV negative. There is no accurate way to test men. You can also soak his penis in vinegar for 20 minutes and look at it with magnification. Any acetowhite areas could be genital warts. But lack of visible acetowhite areas doesn’t mean he doesn’t have it. You simply tell him to use condoms. That there is no visible evidence of HPV but there is no guarantee that he doesn’t have it. Right now there is no test that can definitively say he doesn’t have it and you should just always behave as if you do. Kathy Saradarian, MDBranchville, NJwww.qualityfamilypractice.comSolo 4/03, Practicing since 9/90Practice Partner 5/03Low staffing From: [mailto: ] On Behalf Of Helen YangSent: Wednesday, February 01, 2012 2:35 PMTo: IMP GroupSubject: RE: how to collect specimen from heterosexual men for HPV testing? ,You are correct that there is no FDA approved HPV test for man, but the local Labcorp said they could run the test with the specimen in the Thin Prep solution--as for Pap smear. They could not tell us how to collect the specimen.This patient did not show any signs of wart. He wants to find out about his HPV status before starting a new relationship. He was not interested in any other STD testing.HelenTo: From: glseto@...Date: Wed, 1 Feb 2012 10:59:12 -0800Subject: Re: how to collect specimen from heterosexual men for HPV testing? Helen,According to the CDC, there is no HPV test recommended for males:http://www.cdc.gov/std/hpv/stdfact-hpv-and-men.htm Is there a test for HPV in men?Currently, there is no HPV test recommended for men. The only approved HPV tests on the market are for screening women for cervical cancer. They are not useful for screening for HPV-related cancers or genital warts in men.· Screening for anal cancer is not routinely recommended for men. This is because more research is needed to find out if it can actually prevent anal cancer. However, some experts do recommend yearly anal cancer screening (anal Pap tests) for gay, bisexual, and HIV-positive men – since anal cancer is more common in these men.There is no approved test to find genital warts for men or women. However, most of the time, you can see genital warts. If you think you may have genital warts, you should see a health care provider.There is no test for men to check one’s overall “HPV status.” But HPV usually goes away on its own, without causing health problems. So an HPV infection that is found today will most likely not be there a year or two from now. Screening tests are not available for penile cancer. Even if there was a test for men, how would the results change anything? • If it is positive, but no lesions visible, the patient worries and you give the usual STD prevention advice, but condoms are not foolproof for preventing HPV transmission. • If it is negative, and no lesions visible, the patient feels relieved but you still give the usual STD prevention advice.• If you see genital warts, it doesn't matter what the test results are. You treat appropriately and give the usual STD prevention advice. If he is really worried about HPV, he should consider the HPV vaccine if he is an appropriate candidate. SetoSouth Pasadena, CA A heterosexual male patient requests HPV testing.If we are to collect an anal swab or brush specimen from homosexual patients, where and with what type of swab to collect specimen from heterosexual male? Urethra or just genital skin cells? It wouldn't matter when the patient last showered even if collecting from skin surface, would it?Thank you.Helen

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