Re: [CHB] Prostate Cancer Update, Volume 2, Number 25 - 19 June 2006

[Guest guest]

I get this pretty regularly but the search engine at the site is less than

ideal. Why is it selectively ignoring important research in the field it

purports to excel in ?

This can be found on PubMed but not the site referred to below. Why ? Sammy.

http://watchful-waiting.org

Nutr Cancer. 2005;51(1):32-6.

Pilot study: potential role of vitamin D (Cholecalciferol) in patients with

PSA

relapse after definitive therapy.

Woo TC, Choo R, son M, Chander S, Vieth R.

Toronto-Sunnybrook Regional Cancer Centre, Toronto, Ontario, Canada.

When local treatments for prostate cancer have failed, and prostate-specific

antigen (PSA) rises in the absence of symptoms, there is little consensus as

to

the best management strategy. Calcitriol has been shown to prolong the

doubling

time of PSA in this context, but near-toxic doses are required. We

investigated

the effect of the nutrient vitamin D (cholecalciferol), a biochemical

precursor

of calcitriol, on PSA levels and the rate of rise of PSA in these patients.

Fifteen patients were given 2,000 IU (50 microg) of cholecalciferol daily

and

monitored prospectively every 2-3 mo. In 9 patients, PSA levels decreased or

remained unchanged after the commencement of cholecalciferol. This was

sustained

for as long as 21 mo. Also, there was a statistically significant decrease

in

the rate of PSA rise after administration of cholecalciferol (P = 0.005)

compared with that before cholecalciferol. The median PSA doubling time

increased from 14.3 mo prior to commencing cholecalciferol to 25 mo after

commencing cholecalciferol. Fourteen of 15 patients had a prolongation of

PSA

doubling time after commencing cholecalciferol. There were no side effects

reported by any patient. Further study is needed to confirm this finding and

to

explore the potential therapeutic benefit of nutrient vitamin D in prostate

cancer.

PMID: 15749627

[CHB] Prostate Cancer Update, Volume 2, Number 25 - 19 June 2006

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