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I take Plaquenil (generic) in addition to MTX and it didn't take 6

months to start to work--more like 6 weeks. I can check, but I think

the drug is $50/mo. without insurance.

Sierra

> My rheumy is pushing me to get off Prednesone and wants to put me

on another

> drug to supplement MTX. The 3 cheaper ones are Azathioprine,

Aulfadine, and

> Plaquenil. My immediate problem is in decreasing my Prednesone

doses. The

> other drugs are supposed to help but won't do anything for at least

6

> months, and then have possibly bad side effects. Since all my drugs

come out

> of my pocket, I have to be careful of commitment to any drug. I

know I've

> posted about this before but now have to get more serious about it.

Any

> suggestions?

>

> Dennis

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I take Plaquenil (generic) in addition to MTX and it didn't take 6

months to start to work--more like 6 weeks. I can check, but I think

the drug is $50/mo. without insurance.

Sierra

> My rheumy is pushing me to get off Prednesone and wants to put me

on another

> drug to supplement MTX. The 3 cheaper ones are Azathioprine,

Aulfadine, and

> Plaquenil. My immediate problem is in decreasing my Prednesone

doses. The

> other drugs are supposed to help but won't do anything for at least

6

> months, and then have possibly bad side effects. Since all my drugs

come out

> of my pocket, I have to be careful of commitment to any drug. I

know I've

> posted about this before but now have to get more serious about it.

Any

> suggestions?

>

> Dennis

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Dennis,

From what I've read, you probably should stay away from a MTX + azathioprine

(Imuran) because of toxicity issues.

MTX + sulfasalazine (Azulfidine) + hydroxychloroquine (Plaquenil) is

effective and so are combinations of MTX + hydroxychloroquine and MTX +

sulfasalazine. According to the study below, MTX + hydroxychloroquine is

just about as good as all three in combination.

Have you tried applying for patient assistance programs so you might be able

to have one of the biologics (and faster relief)?

*********

Arthritis Rheum. 2002 May;46(5):1164-70.

Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine,

methotrexate and sulfasalazine, or a combination of the three medications:

results of a two-year, randomized, double-blind, placebo-controlled trial.

O'Dell JR, Leff R, sen G, Haire C, Mallek J, Eckhoff PJ, Fernandez A,

Blakely K, Wees S, Stoner J, Hadley S, Felt J, Palmer W, Waytz P, Churchill

M, Klassen L, G.

University of Nebraska Medical Center, Omaha 68198, USA. jrodell@...

OBJECTIVE: To compare the efficacy of combination therapy with

methotrexate (MTX) and hydroxychloroquine (HCQ), MTX and sulfasalazine

(SSZ), and MTX, HCQ, and SSZ in patients with rheumatoid arthritis (RA).

METHODS: RA patients (n = 171) who had not previously been treated with

combinations of the study medications were randomized to receive 1 of the 3

treatment combinations in this 2-year, double-blind, placebo-controlled

protocol. HCQ was given at a dosage of 200 mg twice a day. The dosage of MTX

was accelerated from 7.5 mg/week to 17.5 mg/week in all patients who were

not in remission. Similarly, the dosage of SSZ was escalated from 500 mg

twice a day to 1 gm twice a day in patients who were not in remission. The

primary end point of the study was the percentage of patients who had a 20%

response to therapy according to the American College of Rheumatology (ACR)

criteria at 2 years.

RESULTS: Intent-to-treat analysis revealed that patients receiving the

triple combination responded best, with 78% achieving an ACR 20% response at

2 years, compared with 60% of those treated with MTX and HCQ (P = 0.05) and

49% of those treated with MTX and SSZ (P = 0.002). Similar trends were seen

for the ACR 50% response, with 55%, 40%, and 29% of patients in the 3

treatment groups, respectively, achieving these results at 2 years (P =

0.005 for the triple combination group versus the MTX and SSZ group). All

combination treatments were well-tolerated. Fourteen patients (evenly

distributed among the 3 groups) withdrew from the protocol because of

symptoms that were potentially related to the study medication.

CONCLUSION: The triple combination of MTX, SSZ, and HCQ is well-tolerated,

and its efficacy is superior to that of the double combination of MTX and

SSZ and is marginally superior to that of the double combination of MTX and

HCQ.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=12115219 & itool=iconabstr

*********

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[ ] Need info-

>

> My rheumy is pushing me to get off Prednesone and wants to put me on

> another

> drug to supplement MTX. The 3 cheaper ones are Azathioprine, Aulfadine,

> and

> Plaquenil. My immediate problem is in decreasing my Prednesone doses. The

> other drugs are supposed to help but won't do anything for at least 6

> months, and then have possibly bad side effects. Since all my drugs come

> out

> of my pocket, I have to be careful of commitment to any drug. I know I've

> posted about this before but now have to get more serious about it. Any

> suggestions?

>

> Dennis

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Dennis,

From what I've read, you probably should stay away from a MTX + azathioprine

(Imuran) because of toxicity issues.

MTX + sulfasalazine (Azulfidine) + hydroxychloroquine (Plaquenil) is

effective and so are combinations of MTX + hydroxychloroquine and MTX +

sulfasalazine. According to the study below, MTX + hydroxychloroquine is

just about as good as all three in combination.

Have you tried applying for patient assistance programs so you might be able

to have one of the biologics (and faster relief)?

*********

Arthritis Rheum. 2002 May;46(5):1164-70.

Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine,

methotrexate and sulfasalazine, or a combination of the three medications:

results of a two-year, randomized, double-blind, placebo-controlled trial.

O'Dell JR, Leff R, sen G, Haire C, Mallek J, Eckhoff PJ, Fernandez A,

Blakely K, Wees S, Stoner J, Hadley S, Felt J, Palmer W, Waytz P, Churchill

M, Klassen L, G.

University of Nebraska Medical Center, Omaha 68198, USA. jrodell@...

OBJECTIVE: To compare the efficacy of combination therapy with

methotrexate (MTX) and hydroxychloroquine (HCQ), MTX and sulfasalazine

(SSZ), and MTX, HCQ, and SSZ in patients with rheumatoid arthritis (RA).

METHODS: RA patients (n = 171) who had not previously been treated with

combinations of the study medications were randomized to receive 1 of the 3

treatment combinations in this 2-year, double-blind, placebo-controlled

protocol. HCQ was given at a dosage of 200 mg twice a day. The dosage of MTX

was accelerated from 7.5 mg/week to 17.5 mg/week in all patients who were

not in remission. Similarly, the dosage of SSZ was escalated from 500 mg

twice a day to 1 gm twice a day in patients who were not in remission. The

primary end point of the study was the percentage of patients who had a 20%

response to therapy according to the American College of Rheumatology (ACR)

criteria at 2 years.

RESULTS: Intent-to-treat analysis revealed that patients receiving the

triple combination responded best, with 78% achieving an ACR 20% response at

2 years, compared with 60% of those treated with MTX and HCQ (P = 0.05) and

49% of those treated with MTX and SSZ (P = 0.002). Similar trends were seen

for the ACR 50% response, with 55%, 40%, and 29% of patients in the 3

treatment groups, respectively, achieving these results at 2 years (P =

0.005 for the triple combination group versus the MTX and SSZ group). All

combination treatments were well-tolerated. Fourteen patients (evenly

distributed among the 3 groups) withdrew from the protocol because of

symptoms that were potentially related to the study medication.

CONCLUSION: The triple combination of MTX, SSZ, and HCQ is well-tolerated,

and its efficacy is superior to that of the double combination of MTX and

SSZ and is marginally superior to that of the double combination of MTX and

HCQ.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=12115219 & itool=iconabstr

*********

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[ ] Need info-

>

> My rheumy is pushing me to get off Prednesone and wants to put me on

> another

> drug to supplement MTX. The 3 cheaper ones are Azathioprine, Aulfadine,

> and

> Plaquenil. My immediate problem is in decreasing my Prednesone doses. The

> other drugs are supposed to help but won't do anything for at least 6

> months, and then have possibly bad side effects. Since all my drugs come

> out

> of my pocket, I have to be careful of commitment to any drug. I know I've

> posted about this before but now have to get more serious about it. Any

> suggestions?

>

> Dennis

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OOPS, I meant 6 WEEKS, not 6 months. Sorry about that, I guess I was asleep

at the switch.

Dennis

[ ] Re: Need info-

>

>

> I take Plaquenil (generic) in addition to MTX and it didn't take 6

> months to start to work--more like 6 weeks. I can check, but I think

> the drug is $50/mo. without insurance.

>

> Sierra

>

>

>> My rheumy is pushing me to get off Prednesone and wants to put me

> on another

>> drug to supplement MTX. The 3 cheaper ones are Azathioprine,

> Aulfadine, and

>> Plaquenil. My immediate problem is in decreasing my Prednesone

> doses. The

>> other drugs are supposed to help but won't do anything for at least

> 6

>> months, and then have possibly bad side effects. Since all my drugs

> come out

>> of my pocket, I have to be careful of commitment to any drug. I

> know I've

>> posted about this before but now have to get more serious about it.

> Any

>> suggestions?

>>

>> Dennis

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OOPS, I meant 6 WEEKS, not 6 months. Sorry about that, I guess I was asleep

at the switch.

Dennis

[ ] Re: Need info-

>

>

> I take Plaquenil (generic) in addition to MTX and it didn't take 6

> months to start to work--more like 6 weeks. I can check, but I think

> the drug is $50/mo. without insurance.

>

> Sierra

>

>

>> My rheumy is pushing me to get off Prednesone and wants to put me

> on another

>> drug to supplement MTX. The 3 cheaper ones are Azathioprine,

> Aulfadine, and

>> Plaquenil. My immediate problem is in decreasing my Prednesone

> doses. The

>> other drugs are supposed to help but won't do anything for at least

> 6

>> months, and then have possibly bad side effects. Since all my drugs

> come out

>> of my pocket, I have to be careful of commitment to any drug. I

> know I've

>> posted about this before but now have to get more serious about it.

> Any

>> suggestions?

>>

>> Dennis

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If I were to choose one of the new ones, what should I try and why? I have

no qualms about giving myself shots or IV's or whatever, I just don't want

to drive to and from every month. , you're right about the azathioprine.

I can't take it without changing to a new BP med and then may not work

otherwise.

Dennis

Re: [ ] Need info-

>

> Dennis,

>

> From what I've read, you probably should stay away from a MTX +

> azathioprine

> (Imuran) because of toxicity issues.

>

> MTX + sulfasalazine (Azulfidine) + hydroxychloroquine (Plaquenil) is

> effective and so are combinations of MTX + hydroxychloroquine and MTX +

> sulfasalazine. According to the study below, MTX + hydroxychloroquine is

> just about as good as all three in combination.

>

> Have you tried applying for patient assistance programs so you might be

> able

> to have one of the biologics (and faster relief)?

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If I were to choose one of the new ones, what should I try and why? I have

no qualms about giving myself shots or IV's or whatever, I just don't want

to drive to and from every month. , you're right about the azathioprine.

I can't take it without changing to a new BP med and then may not work

otherwise.

Dennis

Re: [ ] Need info-

>

> Dennis,

>

> From what I've read, you probably should stay away from a MTX +

> azathioprine

> (Imuran) because of toxicity issues.

>

> MTX + sulfasalazine (Azulfidine) + hydroxychloroquine (Plaquenil) is

> effective and so are combinations of MTX + hydroxychloroquine and MTX +

> sulfasalazine. According to the study below, MTX + hydroxychloroquine is

> just about as good as all three in combination.

>

> Have you tried applying for patient assistance programs so you might be

> able

> to have one of the biologics (and faster relief)?

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Share on other sites

Well, Dennis, if travel is an issue, then Enbrel (etanercept) or Humira

(adalimumab) may be possibilities.

The number for information on the Enbrel Patient Assistance Program is here:

http://www.amgen.com/news/viewPR.jsp?id=661607

Info for both Enbrel and Humira are here:

American College of Rheumatology

" Patient Assistance Programs for Rheumatology-related Drugs " :

http://www.rheumatology.org/public/acrast.asp?aud=pat

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

Re: [ ] Need info-

>

>

>>

>> Dennis,

>>

>> From what I've read, you probably should stay away from a MTX +

>> azathioprine

>> (Imuran) because of toxicity issues.

>>

>> MTX + sulfasalazine (Azulfidine) + hydroxychloroquine (Plaquenil) is

>> effective and so are combinations of MTX + hydroxychloroquine and MTX +

>> sulfasalazine. According to the study below, MTX + hydroxychloroquine is

>> just about as good as all three in combination.

>>

>> Have you tried applying for patient assistance programs so you might be

>> able

>> to have one of the biologics (and faster relief)?

>

>

>

>

>

>

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Share on other sites

Well, Dennis, if travel is an issue, then Enbrel (etanercept) or Humira

(adalimumab) may be possibilities.

The number for information on the Enbrel Patient Assistance Program is here:

http://www.amgen.com/news/viewPR.jsp?id=661607

Info for both Enbrel and Humira are here:

American College of Rheumatology

" Patient Assistance Programs for Rheumatology-related Drugs " :

http://www.rheumatology.org/public/acrast.asp?aud=pat

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

Re: [ ] Need info-

>

>

>>

>> Dennis,

>>

>> From what I've read, you probably should stay away from a MTX +

>> azathioprine

>> (Imuran) because of toxicity issues.

>>

>> MTX + sulfasalazine (Azulfidine) + hydroxychloroquine (Plaquenil) is

>> effective and so are combinations of MTX + hydroxychloroquine and MTX +

>> sulfasalazine. According to the study below, MTX + hydroxychloroquine is

>> just about as good as all three in combination.

>>

>> Have you tried applying for patient assistance programs so you might be

>> able

>> to have one of the biologics (and faster relief)?

>

>

>

>

>

>

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Share on other sites

dennis, the mtrx was working for me, but just about the time it started to work,

my live enzymes went sky high... so i can not take mtrx anymore, but it works

for some people.. and i do not think it is so expensive... and a low does of

prednisone with it until it starts working is good.. my opinion.. :o)

rae

[ ] Need info-

My rheumy is pushing me to get off Prednesone and wants to put me on another

drug to supplement MTX. The 3 cheaper ones are Azathioprine, Aulfadine, and

Plaquenil. My immediate problem is in decreasing my Prednesone doses. The

other drugs are supposed to help but won't do anything for at least 6

months, and then have possibly bad side effects. Since all my drugs come out

of my pocket, I have to be careful of commitment to any drug. I know I've

posted about this before but now have to get more serious about it. Any

suggestions?

Dennis

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Share on other sites

dennis, the mtrx was working for me, but just about the time it started to work,

my live enzymes went sky high... so i can not take mtrx anymore, but it works

for some people.. and i do not think it is so expensive... and a low does of

prednisone with it until it starts working is good.. my opinion.. :o)

rae

[ ] Need info-

My rheumy is pushing me to get off Prednesone and wants to put me on another

drug to supplement MTX. The 3 cheaper ones are Azathioprine, Aulfadine, and

Plaquenil. My immediate problem is in decreasing my Prednesone doses. The

other drugs are supposed to help but won't do anything for at least 6

months, and then have possibly bad side effects. Since all my drugs come out

of my pocket, I have to be careful of commitment to any drug. I know I've

posted about this before but now have to get more serious about it. Any

suggestions?

Dennis

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Share on other sites

Maybe my attitude is getting in the way. The only time I had any trouble

from Prednesone, it caused cramps in my legs. I stopped for a week and

everything has been ok since then. I wonder what might happen in 10-20 years

if I still take it? In the end, will it be worth the pain and effort? I'm 60

and soon 61, so by the time I'm in my 80's it might not make a difference.

Dennis

Re: [ ] Need info-

>

> I have spent the better part of my life trying to get

> off predisone. I was down to 2.5mg beginning of Jan.

> now I'm doing a dose pack. Go very slowly. Isn't it

> funny the cheapest drug we can take (predisone) is the

> one we struggle the most to get off of. Wish it didn't

> have so many side effects :)

> Janc

> --- Dennis W <betnden@...> wrote:

>

>> My rheumy is pushing me to get off Prednesone and

>> wants to put me on another

>> drug to supplement MTX. The 3 cheaper ones are

>> Azathioprine, Aulfadine, and

>> Plaquenil. My immediate problem is in decreasing my

>> Prednesone doses.

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Share on other sites

Maybe my attitude is getting in the way. The only time I had any trouble

from Prednesone, it caused cramps in my legs. I stopped for a week and

everything has been ok since then. I wonder what might happen in 10-20 years

if I still take it? In the end, will it be worth the pain and effort? I'm 60

and soon 61, so by the time I'm in my 80's it might not make a difference.

Dennis

Re: [ ] Need info-

>

> I have spent the better part of my life trying to get

> off predisone. I was down to 2.5mg beginning of Jan.

> now I'm doing a dose pack. Go very slowly. Isn't it

> funny the cheapest drug we can take (predisone) is the

> one we struggle the most to get off of. Wish it didn't

> have so many side effects :)

> Janc

> --- Dennis W <betnden@...> wrote:

>

>> My rheumy is pushing me to get off Prednesone and

>> wants to put me on another

>> drug to supplement MTX. The 3 cheaper ones are

>> Azathioprine, Aulfadine, and

>> Plaquenil. My immediate problem is in decreasing my

>> Prednesone doses.

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Share on other sites

Rae, I'm taking 1.2 cc of MTX weekly and about 10 mg of Prednesone. I was

doing fairly well until my kidneys started acting up and the Rheumy took me

off all anti-inflammatories. Since then I've had tremendous pain at times,

with a lot of normal RA pain that pain meds don't help sometimes. I can't

get off Prednesone by dropping 1 mg at a time. I'm doing pretty well

alternating 10 one day and 9 the next. If I can get another med going, I can

drop off Prednesone quicker, but only if I can get the meds from a free

program.

Dennis

[ ] Need info-

>

>

> My rheumy is pushing me to get off Prednesone and wants to put me on

> another

> drug to supplement MTX. The 3 cheaper ones are Azathioprine, Aulfadine,

> and

> Plaquenil. My immediate problem is in decreasing my Prednesone doses. The

> other drugs are supposed to help but won't do anything for at least 6

> months, and then have possibly bad side effects. Since all my drugs come

> out

> of my pocket, I have to be careful of commitment to any drug. I know I've

> posted about this before but now have to get more serious about it. Any

> suggestions?

>

> Dennis

>

>

>

>

>

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Share on other sites

Rae, I'm taking 1.2 cc of MTX weekly and about 10 mg of Prednesone. I was

doing fairly well until my kidneys started acting up and the Rheumy took me

off all anti-inflammatories. Since then I've had tremendous pain at times,

with a lot of normal RA pain that pain meds don't help sometimes. I can't

get off Prednesone by dropping 1 mg at a time. I'm doing pretty well

alternating 10 one day and 9 the next. If I can get another med going, I can

drop off Prednesone quicker, but only if I can get the meds from a free

program.

Dennis

[ ] Need info-

>

>

> My rheumy is pushing me to get off Prednesone and wants to put me on

> another

> drug to supplement MTX. The 3 cheaper ones are Azathioprine, Aulfadine,

> and

> Plaquenil. My immediate problem is in decreasing my Prednesone doses. The

> other drugs are supposed to help but won't do anything for at least 6

> months, and then have possibly bad side effects. Since all my drugs come

> out

> of my pocket, I have to be careful of commitment to any drug. I know I've

> posted about this before but now have to get more serious about it. Any

> suggestions?

>

> Dennis

>

>

>

>

>

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Share on other sites

Prednisone sends me to the emergency room with a uti

faster than I can think. I tried vitamin c 1000 mg to

balance it out but I will never take it again. Margo

--- Dennis W <betnden@...> wrote:

> Rae, I'm taking 1.2 cc of MTX weekly and about 10 mg

> of Prednesone. I was

> doing fairly well until my kidneys started acting up

> and the Rheumy took me

> off all anti-inflammatories. Since then I've had

> tremendous pain at times,

> with a lot of normal RA pain that pain meds don't

> help sometimes. I can't

> get off Prednesone by dropping 1 mg at a time. I'm

> doing pretty well

> alternating 10 one day and 9 the next. If I can get

> another med going, I can

> drop off Prednesone quicker, but only if I can get

> the meds from a free

> program.

>

> Dennis

>

> [ ] Need info-

> >

> >

> > My rheumy is pushing me to get off Prednesone and

> wants to put me on

> > another

> > drug to supplement MTX. The 3 cheaper ones are

> Azathioprine, Aulfadine,

> > and

> > Plaquenil. My immediate problem is in decreasing

> my Prednesone doses. The

> > other drugs are supposed to help but won't do

> anything for at least 6

> > months, and then have possibly bad side effects.

> Since all my drugs come

> > out

> > of my pocket, I have to be careful of commitment

> to any drug. I know I've

> > posted about this before but now have to get more

> serious about it. Any

> > suggestions?

> >

> > Dennis

> >

> >

> >

> >

> >

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Prednisone sends me to the emergency room with a uti

faster than I can think. I tried vitamin c 1000 mg to

balance it out but I will never take it again. Margo

--- Dennis W <betnden@...> wrote:

> Rae, I'm taking 1.2 cc of MTX weekly and about 10 mg

> of Prednesone. I was

> doing fairly well until my kidneys started acting up

> and the Rheumy took me

> off all anti-inflammatories. Since then I've had

> tremendous pain at times,

> with a lot of normal RA pain that pain meds don't

> help sometimes. I can't

> get off Prednesone by dropping 1 mg at a time. I'm

> doing pretty well

> alternating 10 one day and 9 the next. If I can get

> another med going, I can

> drop off Prednesone quicker, but only if I can get

> the meds from a free

> program.

>

> Dennis

>

> [ ] Need info-

> >

> >

> > My rheumy is pushing me to get off Prednesone and

> wants to put me on

> > another

> > drug to supplement MTX. The 3 cheaper ones are

> Azathioprine, Aulfadine,

> > and

> > Plaquenil. My immediate problem is in decreasing

> my Prednesone doses. The

> > other drugs are supposed to help but won't do

> anything for at least 6

> > months, and then have possibly bad side effects.

> Since all my drugs come

> > out

> > of my pocket, I have to be careful of commitment

> to any drug. I know I've

> > posted about this before but now have to get more

> serious about it. Any

> > suggestions?

> >

> > Dennis

> >

> >

> >

> >

> >

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i am sorry to hear that dennis... i am going to do everything i can to kick this

nasty drug... i am phat and have gained 30 pounds on it... i hate it, now....

but id i flare, i will love it... ha ha haha

rae

*can ya tell i am feeling better?* LOL

i am feling so good and we had the puppies, we almost forgot my enbrel

injection! i just ran in the kitchen and took it out to warm... ha ha ha ha...

[ ] Need info-

>

>

> My rheumy is pushing me to get off Prednesone and wants to put me on

> another

> drug to supplement MTX. The 3 cheaper ones are Azathioprine, Aulfadine,

> and

> Plaquenil. My immediate problem is in decreasing my Prednesone doses. The

> other drugs are supposed to help but won't do anything for at least 6

> months, and then have possibly bad side effects. Since all my drugs come

> out

> of my pocket, I have to be careful of commitment to any drug. I know I've

> posted about this before but now have to get more serious about it. Any

> suggestions?

>

> Dennis

>

>

>

>

>

Link to comment
Share on other sites

i am sorry to hear that dennis... i am going to do everything i can to kick this

nasty drug... i am phat and have gained 30 pounds on it... i hate it, now....

but id i flare, i will love it... ha ha haha

rae

*can ya tell i am feeling better?* LOL

i am feling so good and we had the puppies, we almost forgot my enbrel

injection! i just ran in the kitchen and took it out to warm... ha ha ha ha...

[ ] Need info-

>

>

> My rheumy is pushing me to get off Prednesone and wants to put me on

> another

> drug to supplement MTX. The 3 cheaper ones are Azathioprine, Aulfadine,

> and

> Plaquenil. My immediate problem is in decreasing my Prednesone doses. The

> other drugs are supposed to help but won't do anything for at least 6

> months, and then have possibly bad side effects. Since all my drugs come

> out

> of my pocket, I have to be careful of commitment to any drug. I know I've

> posted about this before but now have to get more serious about it. Any

> suggestions?

>

> Dennis

>

>

>

>

>

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