Guest guest Posted January 21, 2005 Report Share Posted January 21, 2005 , specifically, what infections have you gotten? I'll tell you where to go! Mayo Clinic in Rochester http://www.mayoclinic.org/rochester s Hopkins Medicine http://www.hopkinsmedicine.org [ ] rituximab anyone? > > > I met with my rheumatologist yesterday and we discussed my various > options. I have been on enbrel and mtx but I keep getting infections > (mainly in my lungs) so she suggested I think about either switching > to Humira (which might have the same effect) or enrolling in a > study.The study that is available is for the human model of > Rituximab. Rituximab itself uses half mouse/half human antibodies. I > would try out the all-human version. I am really scared of trying > something so new. Even Rituximab has only been around for a few > years. I told her I would think about it and let her know my > decision. > > Any advice? thoughts? suggestions? > Thanks, > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2005 Report Share Posted January 21, 2005 , specifically, what infections have you gotten? I'll tell you where to go! Mayo Clinic in Rochester http://www.mayoclinic.org/rochester s Hopkins Medicine http://www.hopkinsmedicine.org [ ] rituximab anyone? > > > I met with my rheumatologist yesterday and we discussed my various > options. I have been on enbrel and mtx but I keep getting infections > (mainly in my lungs) so she suggested I think about either switching > to Humira (which might have the same effect) or enrolling in a > study.The study that is available is for the human model of > Rituximab. Rituximab itself uses half mouse/half human antibodies. I > would try out the all-human version. I am really scared of trying > something so new. Even Rituximab has only been around for a few > years. I told her I would think about it and let her know my > decision. > > Any advice? thoughts? suggestions? > Thanks, > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2005 Report Share Posted January 21, 2005 Hi , I have had a burst eardrum, pneumonia, sinus infection and two lung infections. All this has been during the two and 1/2 years I have been on Enbrel. -- In , " " <Matsumura_Clan@m...> wrote: > , specifically, what infections have you gotten? > > > > > I'll tell you where to go! > > Mayo Clinic in Rochester > http://www.mayoclinic.org/rochester > > s Hopkins Medicine > http://www.hopkinsmedicine.org > > > [ ] rituximab anyone? > > > > > > > > I met with my rheumatologist yesterday and we discussed my various > > options. I have been on enbrel and mtx but I keep getting infections > > (mainly in my lungs) so she suggested I think about either switching > > to Humira (which might have the same effect) or enrolling in a > > study.The study that is available is for the human model of > > Rituximab. Rituximab itself uses half mouse/half human antibodies. I > > would try out the all-human version. I am really scared of trying > > something so new. Even Rituximab has only been around for a few > > years. I told her I would think about it and let her know my > > decision. > > > > Any advice? thoughts? suggestions? > > Thanks, > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2005 Report Share Posted January 21, 2005 Hi , I have had a burst eardrum, pneumonia, sinus infection and two lung infections. All this has been during the two and 1/2 years I have been on Enbrel. -- In , " " <Matsumura_Clan@m...> wrote: > , specifically, what infections have you gotten? > > > > > I'll tell you where to go! > > Mayo Clinic in Rochester > http://www.mayoclinic.org/rochester > > s Hopkins Medicine > http://www.hopkinsmedicine.org > > > [ ] rituximab anyone? > > > > > > > > I met with my rheumatologist yesterday and we discussed my various > > options. I have been on enbrel and mtx but I keep getting infections > > (mainly in my lungs) so she suggested I think about either switching > > to Humira (which might have the same effect) or enrolling in a > > study.The study that is available is for the human model of > > Rituximab. Rituximab itself uses half mouse/half human antibodies. I > > would try out the all-human version. I am really scared of trying > > something so new. Even Rituximab has only been around for a few > > years. I told her I would think about it and let her know my > > decision. > > > > Any advice? thoughts? suggestions? > > Thanks, > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 22, 2005 Report Share Posted January 22, 2005 Sorry, , I should have asked all of my questions up front. Have you been on MTX the entire time you have been on Enbrel? When you say " two lung infections, " were your physicians any more specific than that? Are you RF-positive? Aside from the side effects, is the combination working? Is Rituxan an option rather than the study agent (which I am assuming is Humax-CD20)? I'll tell you where to go! Mayo Clinic in Rochester http://www.mayoclinic.org/rochester s Hopkins Medicine http://www.hopkinsmedicine.org [ ] rituximab anyone? >> >> >> > >> > >> > I met with my rheumatologist yesterday and we discussed my > various >> > options. I have been on enbrel and mtx but I keep getting > infections >> > (mainly in my lungs) so she suggested I think about either > switching >> > to Humira (which might have the same effect) or enrolling in a >> > study.The study that is available is for the human model of >> > Rituximab. Rituximab itself uses half mouse/half human > antibodies. I >> > would try out the all-human version. I am really scared of > trying >> > something so new. Even Rituximab has only been around for a few >> > years. I told her I would think about it and let her know my >> > decision. >> > >> > Any advice? thoughts? suggestions? >> > Thanks, >> > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 22, 2005 Report Share Posted January 22, 2005 Sorry, , I should have asked all of my questions up front. Have you been on MTX the entire time you have been on Enbrel? When you say " two lung infections, " were your physicians any more specific than that? Are you RF-positive? Aside from the side effects, is the combination working? Is Rituxan an option rather than the study agent (which I am assuming is Humax-CD20)? I'll tell you where to go! Mayo Clinic in Rochester http://www.mayoclinic.org/rochester s Hopkins Medicine http://www.hopkinsmedicine.org [ ] rituximab anyone? >> >> >> > >> > >> > I met with my rheumatologist yesterday and we discussed my > various >> > options. I have been on enbrel and mtx but I keep getting > infections >> > (mainly in my lungs) so she suggested I think about either > switching >> > to Humira (which might have the same effect) or enrolling in a >> > study.The study that is available is for the human model of >> > Rituximab. Rituximab itself uses half mouse/half human > antibodies. I >> > would try out the all-human version. I am really scared of > trying >> > something so new. Even Rituximab has only been around for a few >> > years. I told her I would think about it and let her know my >> > decision. >> > >> > Any advice? thoughts? suggestions? >> > Thanks, >> > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 22, 2005 Report Share Posted January 22, 2005 ... which one was causing the ling infections?? enbrel or the mtrx? i can not take mtrx anymore.. so i am going to a rheummy on tuesday... wondering what he will put me on???? rae [ ] rituximab anyone? I met with my rheumatologist yesterday and we discussed my various options. I have been on enbrel and mtx but I keep getting infections (mainly in my lungs) so she suggested I think about either switching to Humira (which might have the same effect) or enrolling in a study.The study that is available is for the human model of Rituximab. Rituximab itself uses half mouse/half human antibodies. I would try out the all-human version. I am really scared of trying something so new. Even Rituximab has only been around for a few years. I told her I would think about it and let her know my decision. Any advice? thoughts? suggestions? Thanks, Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 22, 2005 Report Share Posted January 22, 2005 ... which one was causing the ling infections?? enbrel or the mtrx? i can not take mtrx anymore.. so i am going to a rheummy on tuesday... wondering what he will put me on???? rae [ ] rituximab anyone? I met with my rheumatologist yesterday and we discussed my various options. I have been on enbrel and mtx but I keep getting infections (mainly in my lungs) so she suggested I think about either switching to Humira (which might have the same effect) or enrolling in a study.The study that is available is for the human model of Rituximab. Rituximab itself uses half mouse/half human antibodies. I would try out the all-human version. I am really scared of trying something so new. Even Rituximab has only been around for a few years. I told her I would think about it and let her know my decision. Any advice? thoughts? suggestions? Thanks, Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 22, 2005 Report Share Posted January 22, 2005 Hi Rae, I think the reason I was getting lots of infections was because the enbrel was surpressing my immune system so any cold I got turned into an infection. Do you mind if I ask why you can't take mtx anymore? I have been on it for about 4 weeks and haven't seen any improvement yet, just mouth sores and fatigue! > ... which one was causing the ling infections?? enbrel or the mtrx? > > i can not take mtrx anymore.. so i am going to a rheummy on tuesday... wondering what he will put me on???? > > rae > [ ] rituximab anyone? > > > > I met with my rheumatologist yesterday and we discussed my various > options. I have been on enbrel and mtx but I keep getting infections > (mainly in my lungs) so she suggested I think about either switching > to Humira (which might have the same effect) or enrolling in a > study.The study that is available is for the human model of > Rituximab. Rituximab itself uses half mouse/half human antibodies. I > would try out the all-human version. I am really scared of trying > something so new. Even Rituximab has only been around for a few > years. I told her I would think about it and let her know my > decision. > > Any advice? thoughts? suggestions? > Thanks, > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 22, 2005 Report Share Posted January 22, 2005 Hi Rae, I think the reason I was getting lots of infections was because the enbrel was surpressing my immune system so any cold I got turned into an infection. Do you mind if I ask why you can't take mtx anymore? I have been on it for about 4 weeks and haven't seen any improvement yet, just mouth sores and fatigue! > ... which one was causing the ling infections?? enbrel or the mtrx? > > i can not take mtrx anymore.. so i am going to a rheummy on tuesday... wondering what he will put me on???? > > rae > [ ] rituximab anyone? > > > > I met with my rheumatologist yesterday and we discussed my various > options. I have been on enbrel and mtx but I keep getting infections > (mainly in my lungs) so she suggested I think about either switching > to Humira (which might have the same effect) or enrolling in a > study.The study that is available is for the human model of > Rituximab. Rituximab itself uses half mouse/half human antibodies. I > would try out the all-human version. I am really scared of trying > something so new. Even Rituximab has only been around for a few > years. I told her I would think about it and let her know my > decision. > > Any advice? thoughts? suggestions? > Thanks, > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 22, 2005 Report Share Posted January 22, 2005 .. my doctor tried me on mtx 2 different times.. after i was on it for couple of months, my liver enzymes went very high and i had a really bad belly ache... we stopped until my liver enzymes went down and stayed normal for a month, then tried it again... ( after 2 months they went real high again... so he said i should never take mtrx again.. he is sending me to a rheumy on tuesday i have my appointment... *can't wait* i was having a good response to mtrx... just when it started to really take my pain away is when i had the attack... i am hurting pretty bad, again... both knees and my right hand... ugh! well.... i am also so tired i can hardly function... i hate being so tired, feels like if i stood still i would fall asleep right there...( rae [ ] rituximab anyone? > > > > I met with my rheumatologist yesterday and we discussed my various > options. I have been on enbrel and mtx but I keep getting infections > (mainly in my lungs) so she suggested I think about either switching > to Humira (which might have the same effect) or enrolling in a > study.The study that is available is for the human model of > Rituximab. Rituximab itself uses half mouse/half human antibodies. I > would try out the all-human version. I am really scared of trying > something so new. Even Rituximab has only been around for a few > years. I told her I would think about it and let her know my > decision. > > Any advice? thoughts? suggestions? > Thanks, > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 22, 2005 Report Share Posted January 22, 2005 .. my doctor tried me on mtx 2 different times.. after i was on it for couple of months, my liver enzymes went very high and i had a really bad belly ache... we stopped until my liver enzymes went down and stayed normal for a month, then tried it again... ( after 2 months they went real high again... so he said i should never take mtrx again.. he is sending me to a rheumy on tuesday i have my appointment... *can't wait* i was having a good response to mtrx... just when it started to really take my pain away is when i had the attack... i am hurting pretty bad, again... both knees and my right hand... ugh! well.... i am also so tired i can hardly function... i hate being so tired, feels like if i stood still i would fall asleep right there...( rae [ ] rituximab anyone? > > > > I met with my rheumatologist yesterday and we discussed my various > options. I have been on enbrel and mtx but I keep getting infections > (mainly in my lungs) so she suggested I think about either switching > to Humira (which might have the same effect) or enrolling in a > study.The study that is available is for the human model of > Rituximab. Rituximab itself uses half mouse/half human antibodies. I > would try out the all-human version. I am really scared of trying > something so new. Even Rituximab has only been around for a few > years. I told her I would think about it and let her know my > decision. > > Any advice? thoughts? suggestions? > Thanks, > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 23, 2005 Report Share Posted January 23, 2005 > > , specifically, what infections have you gotten? > > > > > > > > > > I'll tell you where to go! > > > > Mayo Clinic in Rochester > > http://www.mayoclinic.org/rochester > > > > s Hopkins Medicine > > http://www.hopkinsmedicine.org > > > > > > [ ] rituximab anyone? > > > > > > > > > > > > > I met with my rheumatologist yesterday and we discussed my > various > > > options. I have been on enbrel and mtx but I keep getting > infections > > > (mainly in my lungs) so she suggested I think about either > switching > > > to Humira (which might have the same effect) or enrolling in a > > > study.The study that is available is for the human model of > > > Rituximab. Rituximab itself uses half mouse/half human > antibodies. I > > > would try out the all-human version. I am really scared of > trying > > > something so new. Even Rituximab has only been around for a few > > > years. I told her I would think about it and let her know my > > > decision. > > > > > > Any advice? thoughts? suggestions? > > > Thanks, > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 23, 2005 Report Share Posted January 23, 2005 > > , specifically, what infections have you gotten? > > > > > > > > > > I'll tell you where to go! > > > > Mayo Clinic in Rochester > > http://www.mayoclinic.org/rochester > > > > s Hopkins Medicine > > http://www.hopkinsmedicine.org > > > > > > [ ] rituximab anyone? > > > > > > > > > > > > > I met with my rheumatologist yesterday and we discussed my > various > > > options. I have been on enbrel and mtx but I keep getting > infections > > > (mainly in my lungs) so she suggested I think about either > switching > > > to Humira (which might have the same effect) or enrolling in a > > > study.The study that is available is for the human model of > > > Rituximab. Rituximab itself uses half mouse/half human > antibodies. I > > > would try out the all-human version. I am really scared of > trying > > > something so new. Even Rituximab has only been around for a few > > > years. I told her I would think about it and let her know my > > > decision. > > > > > > Any advice? thoughts? suggestions? > > > Thanks, > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 23, 2005 Report Share Posted January 23, 2005 Welcome to the group, Clare! I'm so sorry to hear about of all of your troubles, especially the recent discovery of lymphoma. Did you physicians say that they would be using anything else along with the Rituxan (rituximab) to treat your lymphoma? The studies I have read about rituximab have been very encouraging. I'll tell you where to go! Mayo Clinic in Rochester http://www.mayoclinic.org/rochester s Hopkins Medicine http://www.hopkinsmedicine.org [ ] Re: rituximab anyone? >> Dear > > I was on Enbrel a couple of years ago and i experienced the same, > infection after infection, tooth abcesses (never had any probs with > teeth before), chest infections, any cut or sore wouldn't heal...etc. > Anyway, i did love having to not take Mtx though for that period > (yuk!!) but the injections became a major problem at home cause of > blunt needles in pack and my hands are bad. To cut a long story short > they changed me to Remicade which is done by IV very slowly. Not so > many infections but the ones i had were nasty and i always had a sore > throat but on the whole my disease was in part remission (the > Remicade was given every six weeks but after four i would be bad > again) and i was able to work etc. > > However, in November last whilst about to have Remicade i showed my > Rheum doc a lump in my groin which i knew was a lymph node but > thought it was raised due to the RA. The Remicade was stopped and Mtx > (hurrah!!)too, had node out and was diagnoised a mouth ago with > follicular non-hodgkin's lymphoma (cancer) and they will be treating > me with Rituximab which is why when i saw your message i was amazed. > My Oncology doc has told me it will put my RA into remission with > very few side effects. I start on the 3rd of Feb and will let you > know how i get on. To have no RA even for a short while shows to > every cloud there is a silver lining. > > You take care >> Best wishes > Clare Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 23, 2005 Report Share Posted January 23, 2005 Welcome to the group, Clare! I'm so sorry to hear about of all of your troubles, especially the recent discovery of lymphoma. Did you physicians say that they would be using anything else along with the Rituxan (rituximab) to treat your lymphoma? The studies I have read about rituximab have been very encouraging. I'll tell you where to go! Mayo Clinic in Rochester http://www.mayoclinic.org/rochester s Hopkins Medicine http://www.hopkinsmedicine.org [ ] Re: rituximab anyone? >> Dear > > I was on Enbrel a couple of years ago and i experienced the same, > infection after infection, tooth abcesses (never had any probs with > teeth before), chest infections, any cut or sore wouldn't heal...etc. > Anyway, i did love having to not take Mtx though for that period > (yuk!!) but the injections became a major problem at home cause of > blunt needles in pack and my hands are bad. To cut a long story short > they changed me to Remicade which is done by IV very slowly. Not so > many infections but the ones i had were nasty and i always had a sore > throat but on the whole my disease was in part remission (the > Remicade was given every six weeks but after four i would be bad > again) and i was able to work etc. > > However, in November last whilst about to have Remicade i showed my > Rheum doc a lump in my groin which i knew was a lymph node but > thought it was raised due to the RA. The Remicade was stopped and Mtx > (hurrah!!)too, had node out and was diagnoised a mouth ago with > follicular non-hodgkin's lymphoma (cancer) and they will be treating > me with Rituximab which is why when i saw your message i was amazed. > My Oncology doc has told me it will put my RA into remission with > very few side effects. I start on the 3rd of Feb and will let you > know how i get on. To have no RA even for a short while shows to > every cloud there is a silver lining. > > You take care >> Best wishes > Clare Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 23, 2005 Report Share Posted January 23, 2005 Dear Clare, Thanks for responding to my post. So sorry to hear about the lymphoma. Thank goodness you will get some relief from the RA. Battling both at the same time would be a lot. Do keep us informed and my thoughts are with you. > > > , specifically, what infections have you gotten? > > > > > > > > > > > > > > > I'll tell you where to go! > > > > > > Mayo Clinic in Rochester > > > http://www.mayoclinic.org/rochester > > > > > > s Hopkins Medicine > > > http://www.hopkinsmedicine.org > > > > > > > > > [ ] rituximab anyone? > > > > > > > > > > > > > > > > > > I met with my rheumatologist yesterday and we discussed my > > various > > > > options. I have been on enbrel and mtx but I keep getting > > infections > > > > (mainly in my lungs) so she suggested I think about either > > switching > > > > to Humira (which might have the same effect) or enrolling in a > > > > study.The study that is available is for the human model of > > > > Rituximab. Rituximab itself uses half mouse/half human > > antibodies. I > > > > would try out the all-human version. I am really scared of > > trying > > > > something so new. Even Rituximab has only been around for a few > > > > years. I told her I would think about it and let her know my > > > > decision. > > > > > > > > Any advice? thoughts? suggestions? > > > > Thanks, > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 23, 2005 Report Share Posted January 23, 2005 Dear Clare, Thanks for responding to my post. So sorry to hear about the lymphoma. Thank goodness you will get some relief from the RA. Battling both at the same time would be a lot. Do keep us informed and my thoughts are with you. > > > , specifically, what infections have you gotten? > > > > > > > > > > > > > > > I'll tell you where to go! > > > > > > Mayo Clinic in Rochester > > > http://www.mayoclinic.org/rochester > > > > > > s Hopkins Medicine > > > http://www.hopkinsmedicine.org > > > > > > > > > [ ] rituximab anyone? > > > > > > > > > > > > > > > > > > I met with my rheumatologist yesterday and we discussed my > > various > > > > options. I have been on enbrel and mtx but I keep getting > > infections > > > > (mainly in my lungs) so she suggested I think about either > > switching > > > > to Humira (which might have the same effect) or enrolling in a > > > > study.The study that is available is for the human model of > > > > Rituximab. Rituximab itself uses half mouse/half human > > antibodies. I > > > > would try out the all-human version. I am really scared of > > trying > > > > something so new. Even Rituximab has only been around for a few > > > > years. I told her I would think about it and let her know my > > > > decision. > > > > > > > > Any advice? thoughts? suggestions? > > > > Thanks, > > > > Quote Link to comment Share on other sites More sharing options...
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