(Fwd) [PPML] More detail on pomegranate

[Guest guest]

After a frustrating time to get the full text of the

pomegranate article, which was promised for publication

July 1 but never made it online. I was able to purchase it

y/day and have expanded my report:

http://psa-rising.com/eatingwell/pomegranate-juice06.htm

Ill talk to the researcher to see he can let me post the

entire article on psa-rising.com. For now I've extracted

more than the gist.

Couple of issues brought up by members of PCa lists are

clearer now. Firstly, the researchers deny any estrogneic

effect of pomegranate is involved in the lowering of PSA.

They say testosterone did not not fall in the patients.

" Patients were followed in 3-month intervals for serum

PSA, and blood and urine were collected for laboratory studies.

In addition measurements were made of the effect of

pomegranate on the patients' hormone levels (testosterone,

estradiol, sex hormone-binding globulin,

dehydroepiandrosterone, insulin-like growth factor, and

androstenedione). "

They found no effect on testosterone levels. An earlier

study (PNAS, 2005), which Dr. Ignarro edited on behalf of

a

group in Wisconsin, found that pomegranate downregulates

the androgen receptor on prostate cancer cells. Pantuck

makes no reference to this but states:

" The lack of any observed effect on serum androgen levels

suggests that the effect is not primarily hormonal in

nature. "

Secondly they state that they don't believe PSA was lowered

only " artifactually, " i.e. lowered by some fluke effect of

polyphenol content of the juice without any change in the

cancer. They say their view is:

" is supported by a separate pharmacokinetic study (data not

shown), in which there was no relationship between

circulating ellagic acid and PSA when both were serially

and simultaneously measured after pomegranate juice

consumption. "

Patients:

Of the patients enrolled, 68% were originally treated by

radical prostatectomy, 10% by external beam radiotherapy,

10% by brachytherapy, 7% by surgery and radiation, and 5%

by cryotherapy.

The original Gleason scores were read as intermediate

(5-7}

in 94% of patients, whereas 6% had Gleason 4 cancers.

All patients were clinical or pathologic N 0 and M 0, and

63% were clinically or pathologically staged with organ-

confined disease, whereas 37% had locally advanced cancers

extending into the periprostatic or seminal vesicle

tissues. At study entry, median PSA for the cohort was 1.05

ng/mL (average, 2.23 ± 2.58 ng/mL).

A series of PSA measurements before study entry determined

each patient's baseline PSA doubling time (PSADT). Each

patient had a minimum of three pretreatment PSA values

measured over a minimum of 6 months before study entry.

Juice dose: " Patients were treated with 8 ounces of

pomegranate juice by mouth daily (Wonderful variety,

equivalent to 570 mg total polyphenol gallic acid

equivalents daily) until meeting disease progression end

points. "

Method of producing the juice is descrbed (on my psa-r

page, near the bottom).

Results: Essentially what was previously reported,in more

detail. I have posted a chart of the log PSA slopes of the

patients, its quite scrambled, but take a look. Click on it

and it will enlarge.

I expect to continue editing this page and might turn their

patient results into a table if that helps.

For now

Jacquie

[Guest guest]

After reading this information, I went to the local grocery and bought

some pomegranate juice, and ya know what? This was the first time I

had ever tasted it, and it's delicious!!! Actually, it is a

combination of blueberry and pomegranate, but if 8 ounces of this stuff

a day will help, then why not?

Thanks for the information.