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Skin test could screen prostate cancer

By Marsa / Health and Fitness News Service

snip

the University of California-San Diego, uses skin samples to test for

prostate cancer. Investigators there discovered prostate cancer cells

produce many types of substances that influence the growth of other

tissues and organs, including the skin, the body's largest organ.

Because the skin's surface is so large, scientists wondered if the skin

would act like a magnifying glass and allow them a better view of tumor

cells percolating through the body.

They also wondered whether changes in the way genes behaved when they

were affected by prostate cancer were apparent on the skin's surface,

according to Dr. Wachsman, an oncologist who conducted the

recent research.

To find out whether this is true, Wachsman has begun a $1.8 million

study that will eventually encompass 450 men.

One-third of the volunteers will have had positive biopsies for prostate

cancer, another third will have elevated PSA levels but no evidence of

cancer, while the remainder will have negligible PSA levels.

Skin samples will be collected from each volunteer using a technology

known as Epidermal Genetic Information Retrieval. It consists of

specially designed adhesive tapes, about the size of a quarter, that

" can harvest surface skin cells from which genetic matter can be

extracted, " says Benson, a scientist at DermTech International,

the San Diego, Calif. company that makes the tapes.

The samples will then be analyzed to identify genes on the skin's

surface.

" We're looking for skin cells that have alterations in their gene

expression due to the cancer, " says Wachsman, who plans to analyze at

least 47,000 genes.

" Eventually, we'll boil those numbers down to the top 25 genes that

statistically are the most predictive of cancer, " he says.

snip

http://www.detnews.com/2005/fitness/0510/04/H11-336003.htm

Kathy Meade

Arlington Educational Consulting

http://www.vapcacoalition.org/

phone

fax

" Respect means listening until everyone has been heard and understood,

only then is there a possibility of " Balance and Harmony " the goal of

Indian Spirituality. "

" Dave Chief, Grandfather of Red Dog "

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