Gout treated with PEG approved by FDA 2010

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From New england JOURNAL of MedicineCLINICAL PRACTICEGout…of allopurinol) in lowering serum urate to 5 mg per deciliter or less. Uricase converts uric acid into soluble allantoin. Pegloticase, a polyethylene glycolated(pegylated) modified porcine recombinant uricase, was approved by the FDA in 2010 for chronic gout that is refractory to conventional treatments…February 3, 2011Neogi T.N Engl J Med 2011; 364:443 - 452CMEFull Text AudioThis article reviews the use of NSAIDs, colchicine, glucocorticoids, and corticotropin for acute flares of gout and the use of long-term urate-lowering therapies. Both well-established therapies and newer urate-lowering therapies are discussed.PDFSave