Alpha-Lipoic Acid and Sore, Burning Mouth

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Alpha-Lipoic Acid and Sore, Burning Mouth

Reference: " Alpha-Lipoic acid treatment of 31 patients with sore,

burning mouth, " Steele JC, Bruce AJ, et al, Oral Dis, 2008 Feb 10; [Epub

ahead of print]. (Address: Department of Dermatology, Mayo Clinic,

Rochester, MN, USA).

Summary: In a retrospective review of the medical records of 195

consecutive patients who sought treatment for sore, burning mouth,

treatment with alpha-lipoic acid (600 mg/d in divided doses) was found

to benefit 35% of patients. Of the 195 patients whose records were

reviewed, 35 patients were available for follow-up, out of which 31 took

the alpha-lipoic acid supplements as recommended. Of these 31 patients,

11 reported some benefit as a result of taking alpha-lipoic acid. Six

subjects (19%) felt 'mostly better,' five (16%) felt 'somewhat better,'

fourteen (45%) reported no difference, four (13%) did not know if there

had been improvement, and two (7%) reported a worsening of symptoms. The

authors conclude, " Because we examined only a small number of patients

and relied on a subjective outcome assessment, further larger studies

using a prospective, randomized, controlled, and double-blind structure

are warranted. "

--

ne Holden, MS, RD

" Ask the Parkinson Dietitian " http://www.parkinson.org/

" Eat well, stay well with Parkinson's disease "

" Parkinson's disease: Guidelines for Medical Nutrition Therapy "

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