Guest guest Posted January 23, 2006 Report Share Posted January 23, 2006 Dr. Mc. Do you ever vary the timing of the dosage of TD-DMSA? I would like to consider this but for an adult the every 8 hours wouldn't work and I would prefer the every 48 hour dosing as many do who use TD-DMPS? Thanks. Michele Jaquelyn McCandless wrote: Hi! I received a personal query about my use of DMSA, and thought I would send it to the group in case anyone else needs this information: I much prefer DMSA for detoxification as it chelates both mercury and lead and very safely. If it is from Lee Silsby's, I prescribe 5mg per kg q 8 hours three days on and 11 days off. I dislike that Alan Israel there makes it a proprietary formula so we can't know what is in it, he charges a lot, and puts down all other pharmacies (not cool!). However, he does make an effective chelator. When Coastal came up with their TD version, I switched almost all of my patients to that pharmacy, which I love, and got the same results. With them, I use 5mg/kg on the very small kids, but for the bigger ones >35-40#, I use 10mg/kg every 8 hours 3 days on 11 days off. Several kids had itching with the DMSO, which is a great source of sulfur and very good for the kids, and if a very light touch of Benedryl cream did not solve the problem, (put on just before you put the chelator on) I would put them back on Silsby's formula, because the most important thing is always to get the kids well no matter about any personal feelings. No matter which formula you use, you have to attend carefully to the zinc and magnesium levels, the most important limiting factors for the success of chelation. I try to keep zinc to one mg per # plus 20 daily while actively chelating, and magnesium to bowel tolerance. Transdermal magnesium is very useful too for kids whose bowels are extremely sensitive to magnesium, but give me looser stools over constipation any day, as constipation causes toxins to go back into the blood stream and this is extremely bad when detoxing/chelating heavy metals. Per the discussion recently re Boyd Haley's thoughts about selenium tying up (sequestering) mercury and it not being available to bind with the chelation agent, I think it is OK to cut this out in terms of separate selenium nutrients, but for the mixes, such as Pic-Mins or other multiple mineral/vitamin preparations, I do not think they have to be taken out, and I continue them as usual. Dr. JM Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 23, 2006 Report Share Posted January 23, 2006 If my son has not done well after his 2nd round of DMSA...regression and loss of joy, etc., should I consider switching to Lee Silsby's? Could the DMSO cause this kind of reaction? Thanks! --- Michele Crozier wrote: > Dr. Mc. > Do you ever vary the timing of the dosage of > TD-DMSA? I would like to consider this but for an > adult the every 8 hours wouldn't work and I would > prefer the every 48 hour dosing as many do who use > TD-DMPS? > Thanks. > Michele > > Jaquelyn McCandless wrote: > Hi! I received a personal query about my use of > DMSA, and thought I would send it to the group in > case anyone else needs this information: > > I much prefer DMSA for detoxification as it chelates > both mercury and lead and very safely. If it is > from Lee Silsby's, I prescribe 5mg per kg q 8 hours > three days on and 11 days off. I dislike that Alan > Israel there makes it a proprietary formula so we > can't know what is in it, he charges a lot, and puts > down all other pharmacies (not cool!). However, he > does make an effective chelator. When Coastal came > up with their TD version, I switched almost all of > my patients to that pharmacy, which I love, and got > the same results. With them, I use 5mg/kg on the > very small kids, but for the bigger ones >35-40#, I > use 10mg/kg every 8 hours 3 days on 11 days off. > Several kids had itching with the DMSO, which is a > great source of sulfur and very good for the kids, > and if a very light touch of Benedryl cream did not > solve the problem, (put on just before you put the > chelator on) I would put them back on Silsby's > formula, because the most important thing is always > to get the kids well no > matter about any personal feelings. No matter which > formula you use, you have to attend carefully to the > zinc and magnesium levels, the most important > limiting factors for the success of chelation. I > try to keep zinc to one mg per # plus 20 daily while > actively chelating, and magnesium to bowel > tolerance. Transdermal magnesium is very useful too > for kids whose bowels are extremely sensitive to > magnesium, but give me looser stools over > constipation any day, as constipation causes toxins > to go back into the blood stream and this is > extremely bad when detoxing/chelating heavy metals. > Per the discussion recently re Boyd Haley's thoughts > about selenium tying up (sequestering) mercury and > it not being available to bind with the chelation > agent, I think it is OK to cut this out in terms of > separate selenium nutrients, but for the mixes, such > as Pic-Mins or other multiple mineral/vitamin > preparations, I do not think they have to be taken > out, and I continue them as usual. Dr. JM > > [Non-text portions of this message have been > removed] > > > > Many frequently asked questions and answers can be > found at > <http://forums.autism-rxguidebook.com/default.aspx> > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 23, 2006 Report Share Posted January 23, 2006 I have never used this schedule with DMSA so I cannot speak about it. Who advocates this schedule? Most adults I have chelated have not needed the transdermal and have no problem doing the oral every 8 hours from Friday morning to Sunday night. With the half-life it seems like you would be starting over every time, but please let us know who is advocating this and what their rationale is. My understanding is that it does not work like DMPS, which can be given more infrequently. Dr. JM Michele Crozier wrote: Dr. Mc. Do you ever vary the timing of the dosage of TD-DMSA? I would like to consider this but for an adult the every 8 hours wouldn't work and I would prefer the every 48 hour dosing as many do who use TD-DMPS? Thanks. Michele Jaquelyn McCandless wrote: Hi! I received a personal query about my use of DMSA, and thought I would send it to the group in case anyone else needs this information: I much prefer DMSA for detoxification as it chelates both mercury and lead and very safely. If it is from Lee Silsby's, I prescribe 5mg per kg q 8 hours three days on and 11 days off. I dislike that Alan Israel there makes it a proprietary formula so we can't know what is in it, he charges a lot, and puts down all other pharmacies (not cool!). However, he does make an effective chelator. When Coastal came up with their TD version, I switched almost all of my patients to that pharmacy, which I love, and got the same results. With them, I use 5mg/kg on the very small kids, but for the bigger ones >35-40#, I use 10mg/kg every 8 hours 3 days on 11 days off. Several kids had itching with the DMSO, which is a great source of sulfur and very good for the kids, and if a very light touch of Benedryl cream did not solve the problem, (put on just before you put the chelator on) I would put them back on Silsby's formula, because the most important thing is always to get the kids well no matter about any personal feelings. No matter which formula you use, you have to attend carefully to the zinc and magnesium levels, the most important limiting factors for the success of chelation. I try to keep zinc to one mg per # plus 20 daily while actively chelating, and magnesium to bowel tolerance. Transdermal magnesium is very useful too for kids whose bowels are extremely sensitive to magnesium, but give me looser stools over constipation any day, as constipation causes toxins to go back into the blood stream and this is extremely bad when detoxing/chelating heavy metals. Per the discussion recently re Boyd Haley's thoughts about selenium tying up (sequestering) mercury and it not being available to bind with the chelation agent, I think it is OK to cut this out in terms of separate selenium nutrients, but for the mixes, such as Pic-Mins or other multiple mineral/vitamin preparations, I do not think they have to be taken out, and I continue them as usual. Dr. JM Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 23, 2006 Report Share Posted January 23, 2006 DMSO is the carrier for the transdermal secretin, and has many healing benefits on its own; it is a great source of sulfur. I suppose if a child were sensitive to exogenous sulfur it might cause some kind of reaction - I really do not know in your case, not knowing your son's history or level of toxicity. Regression with chelation usually means metals are being moved and they are constipated so toxins are going back in or they do not have enough zinc (and/or magnesium), and I'm not sure that would not be the case with any chelator is he is very toxic. I cannot advise you on this one; it seems a bit early to give up, but you live with him, and I usually trust mom's intuition. Dr. JM Royster wrote: If my son has not done well after his 2nd round of DMSA...regression and loss of joy, etc., should I consider switching to Lee Silsby's? Could the DMSO cause this kind of reaction? Thanks! --- Michele Crozier wrote: > Dr. Mc. > Do you ever vary the timing of the dosage of > TD-DMSA? I would like to consider this but for an > adult the every 8 hours wouldn't work and I would > prefer the every 48 hour dosing as many do who use > TD-DMPS? > Thanks. > Michele > > Jaquelyn McCandless wrote: > Hi! I received a personal query about my use of > DMSA, and thought I would send it to the group in > case anyone else needs this information: > > I much prefer DMSA for detoxification as it chelates > both mercury and lead and very safely. If it is > from Lee Silsby's, I prescribe 5mg per kg q 8 hours > three days on and 11 days off. I dislike that Alan > Israel there makes it a proprietary formula so we > can't know what is in it, he charges a lot, and puts > down all other pharmacies (not cool!). However, he > does make an effective chelator. When Coastal came > up with their TD version, I switched almost all of > my patients to that pharmacy, which I love, and got > the same results. With them, I use 5mg/kg on the > very small kids, but for the bigger ones >35-40#, I > use 10mg/kg every 8 hours 3 days on 11 days off. > Several kids had itching with the DMSO, which is a > great source of sulfur and very good for the kids, > and if a very light touch of Benedryl cream did not > solve the problem, (put on just before you put the > chelator on) I would put them back on Silsby's > formula, because the most important thing is always > to get the kids well no > matter about any personal feelings. No matter which > formula you use, you have to attend carefully to the > zinc and magnesium levels, the most important > limiting factors for the success of chelation. I > try to keep zinc to one mg per # plus 20 daily while > actively chelating, and magnesium to bowel > tolerance. Transdermal magnesium is very useful too > for kids whose bowels are extremely sensitive to > magnesium, but give me looser stools over > constipation any day, as constipation causes toxins > to go back into the blood stream and this is > extremely bad when detoxing/chelating heavy metals. > Per the discussion recently re Boyd Haley's thoughts > about selenium tying up (sequestering) mercury and > it not being available to bind with the chelation > agent, I think it is OK to cut this out in terms of > separate selenium nutrients, but for the mixes, such > as Pic-Mins or other multiple mineral/vitamin > preparations, I do not think they have to be taken > out, and I continue them as usual. Dr. JM > > [Non-text portions of this message have been > removed] > > > > Many frequently asked questions and answers can be > found at > <http://forums.autism-rxguidebook.com/default.aspx> > > > > > Quote Link to comment Share on other sites More sharing options...
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