L-Carnitine Reduces Severity of Physical and Mental Fatigue, Increases Cognitive Functions in Centenarians

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Supplementation with L-Carnitine Reduces Severity of Physical and

Mental Fatigue and Increases Cognitive Functions in Centenarians

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Reference: " L-Carnitine treatment reduces severity of physical and

mental fatigue and increases cognitive functions in centenarians: a

randomized and controlled clinical trial, " Malaguarnera M, Motta M, et

al, Am J Clin Nutr, 2007; 86(6): 1738-1744. (Address: M Malaguarnera,

Department of Senescence, Urological, and Neurological Sciences,

Ospedale Cannizzaro, Viale Messina, 829 -95125 Catania, Italy. E-mail:

malaguar@... ).

Summary: In a randomized, double-blind, placebo-controlled study

involving 66 centenarians with onset of fatigue after even slight

physical activity, results indicate that supplementation with

levocarnitine may exert beneficial effects on physical and mental

fatigue and on cognitive functions. The subjects were randomized to 2 g

levocarnitine (n = 32) or placebo (n = 34) daily for a period of 6

months. At intervention end, subjects in the levocarnitine group showed

significant reductions in total fat mass and significant increases in

total muscle mass, plasma concentrations of total carnitine, and plasma

concentrations of short and long-chain acylcarnitine, compared with

subjects in the placebo group. Additionally, subjects in the

levocarnitine group showed significant decreases in physical fatigue,

mental fatigue, and fatigue severity, along with significant improvement

in Mini-Mental State Examination scores, compared with subjects in the

placebo group. Thus, the authors conclud e, " Our study indicates that

oral administration of levocarnitine produces a reduction of total fat

mass, increases total muscular mass, and facilitates an increased

capacity for physical and cognitive activity by reducing fatigue and

improving cognitive functions. "

--

ne Holden, MS, RD < fivestar@... >

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