Guest guest Posted June 25, 2006 Report Share Posted June 25, 2006 Hi Sue - I checked one of my favorite references - the PDR Online (Physician's Desk Reference) regarding Vicodin and its side effects. While depression is not listed as a direct side effect, it does say that it can interact with tricyclic antidepressants (and isn't Prozac one of those?) to make the effects of either drug either stronger, weaker or altered. So while I don't think it's possible the Vicodin is " causing " the depression, it may be making your Prozac not work as well as it should (and the Vicodin, for that matter!). You should talk to your doctor about this immediately - the doctor who prescribed the Prozac might be most helpful in understanding its interactions. That said, it would be surprising to me if this effect happened with just three pills, even if it were interacting with your antidepressant, given that Prozac takes a while to clear your system anyway. But who knows?! We're all different, so it's not out of the realm of possibility. I'm proud of you for moving past your preconceptions and taking this first step to get better control of your pain. Don't get discouraged if the first drug doesn't work - sometimes it takes a lot of experimentation to find the right combination of meds to help both our pain and other conditions when you have a complicated health situation. My pain doc and I have been " tinkering " with various meds for over a year now, always trying to improve my pain control and the related issues. I'm not saying it will take that long to get pain relief, but just be prepared for some trial and error at the start. Hang in there! Oh, and btw, if you're interested in checking out the facts on almost any drug, the PDR Online is a great resource. Here's the website: www.pdrhealth.com Cheryl in AZ Quote Link to comment Share on other sites More sharing options...
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