Tim

[Guest guest]

I was wondering about that also. Does the PSC make you more prone to other

cancers. Remember Laurie's cancer is all over her abdomen. The doctors have

told us that having PSC makes Phil more prone to colon cancer.

Peg

I have a question. In Mike's case he was diagnosed with cholangiocarcinoma.

But in Mette's case, although she had PSC was the cause of death cancer, the

operation (only in the sense that she was put under) or cholangiocarcinoma?

[Guest guest]

I have a question. In Mike's case he was diagnosed with cholangiocarcinoma.

But in Mette's case, although she had PSC was the cause of death cancer, the

operation (only in the sense that she was put under) or cholangiocarcinoma?

There were lost of similarities between she and Mike, for example blood

clots... which I am told are common with cancer patients...severe back pain,

although meds and treatment had been administered.....not being able to

retain foods.....and finally cancer in the abdomen. We thought he was

retaining fluid which has been seen as the normal progression. But we never

thought to have that fluid tested until the very end. He also was up and

moving to some degree, talking etc., but then slowly became non responsive

and blood pressure drooped......... I guess what I am asking is although the

cause of death is different, (possibly,) is the progression the same? SO how

do you differentiate the difference between liver failure do to PSC,

cholangiocarcinoma, and so called cancer of the abdomen? Especially without

an autopsy

Lynn

[Guest guest]

>But in Mette's case, although she had PSC was the cause of death cancer, the

>operation (only in the sense that she was put under) or cholangiocarcinoma

there was a autopsy..I have not and will not read it..

my opinion is death was due to complications of the surgery in july to remove

her gall bladder cancer..

that complication being a blood clot in the portal vein..

she had no blood flow in the portal vein since oct or nov..

that clot caused liver cell death in some areas which then liquified and

abscessed..

at the same time the cancer reoccurred/continued and spread inside the

abdomen..

had the cancer not been so present maybe the surgeons plan (section away the

dead half of the liver, repair the hole in the intestines and install a

feeding tube) could have given her the chance she needed to regenerate liver

and maybe even an alternate venial blood supply--the doc said he had seen same

before..

ah but, it was not to be.

dd---as far as I know there was no cholangiocarcinoma

[Guest guest]

--- P Alfeld wrote:

> I was wondering about that also. Does the PSC make you more

> prone to other cancers. Remember Laurie's cancer is all over

> her abdomen. The doctors have told us that having PSC makes

> Phil more prone to colon cancer.

> Peg

As far as I know PSC doesn't increase your risk of cancers,

other than cholangiocarcinoma, any more than other liver

diseases (which increase risk of hepatocellular carcinoma). The

high incidence of UC among PSC patients gives us the higher risk

of colon cancer. The colon cancer is associated with UC not PSC

alone. (And recent studies hinted that colon cancer risk could

be cut in half by taking URSO/Actigall.)

I hope cholangiocarcinoma is reduced also, but studies to check

that are hard to conduct because it is so hard to confirm or

deny cholangiocarcinoma. Examination of livers removed during

transplant may eventually produce some data on that.

I don't know the origin of Laurie's cancer, but it evidently had

begun its spread prior to her transplant. So even though the

primary tumor was removed with the liver, what was left spread

as a generalized cancer throughout her abdomen.

>

> I have a question. In Mike's case he was diagnosed with

> cholangiocarcinoma. But in Mette's case, although she had PSC

> was the cause of death cancer, the operation (only in the

> sense that she was put under) or cholangiocarcinoma?

> Lynn

Cholangiocarcinoma is just a definite form of cancer located in

the bile ducts, just as Hepatocellular carcinoma is cancer of

the primary liver cells. Both Mike and Mette had cancers which

metastasized (spread) to other locations. Viewed with the true

vision of hindsight, Mette's symptoms fit a long term battle

with cancer in her final months. Mette's cancer was originally

diagnosed as of the gall bladder, not cholangiocarcinoma, though

I suspect there is not much difference in behavior and

difficulty of detection between the two.

As I sat down to reply I thought - I don't know enough about

this, Aubrey should answer. I still think so. I probably have

missed much and gotten some thing wrong.

TimR

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