What is OSR (again)

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Posted this a while back, feel free to search messages (in the search box at the

top and bottom) for more info on OSR.

Go to www.ctiscience.com.

What is OSR?

OSR stands for Oxidative Stress Relief. OSR, a patented new discovery, is a safe

and non & #8208;toxic nutritional supplement that dramatically reduces oxidative

stress by significantly increasing glutathione in its " reduced form " called GSH.

The increased amount of GSH, or reduced glutathione, allows the body to scavenge

harmful free radicals and restore its own detoxifying mechanisms. OSR has been

shown to elevate glutathione levels most likely due to its positive ORAC score

(Oxygen Radical Absorbance Capacity) and the fact that it is more lipid soluble

than other hydroxyl radical scavengers. This is how it works: OSR scavenges free

radicals leading to an increase of reduced glutathione, or GSH, inside the

cells. The increased levels of GSH can then be used to detoxify the body of

toxins through the attachment of GSH by an enzyme known as

Glutathione & #8208;S & #8208;Transferase. Toxins, tightly bound and rendered inert,

are processed through the liver and then leave the body safely through the liver

or biliary system. OSR is a unique supplement for restoring and maintaining good

health from exposure to pollutants, toxins and heavy metals and other sources

that produce dangerous free radicals causinitions in the body.

causingg numerous harmful conditions.

What is Oxidative Stress?

Oxidative Stress is a condition that occurs when the available supply of

antioxidants, the body's defense mechanisms, is not sufficient to handle and

neutralize free radicals, potentially harmful and unstable molecules formed when

weak bonds split leaving the molecules with an odd, unpaired electron. The

resulting condition – oxidative stress – can create massive cell damage that can

result in cellular mutations, tissue breakdown, immune compromise and a host of

other harmful conditions and disorders.

What are Reactive Oxygen Free Radicals?

Reactive oxygen free radicals are highly unstable oxygen & #8208;containing

molecules that interact quickly and aggressively with other molecules in our

bodies to oxidize them and inhibit their biological activity. Free radicals are

capable of modifying the proteins, enzymes and lipids of membranes, as well as

penetrating into the DNA of a cell and damaging the genome. Excess free radicals

also damage mitoch

ondria, the leading energy producing organel of the cell. Free radicals are

unstable because they have unpaired electrons in their molecular structure. This

instability causes them to react almost instantly with any substance in their

vicinity. This process is called an " oxidation reaction. "

How do Free Radicals relate to Antioxidants, Oxidative Stress and Human Health?

Oxidation reactions are crucial for life, but they can also be damaging. In

fact, oxygen, or hydroxyl free radicals are especially dangerous. Oxidative

stress occurs when the production of hydroxyl free radicals exceeds the body's

natural antioxidant defense

mechanisms, causing damage to DNA, proteins, and lipids. To survive, plants and

animals have developed complex systems with multiple types of antioxidants, such

as glutathione, Vitamin C, Vitamin E, and enzymes, that either prevent oxidative

stress caused by free radicals or by removing free rad

icals before they can damage important parts of the cell. Free radicals can play

a useful role in our body. Some free radicals, for example, form normally during

metabolism. The body's immune system can purposefully create them to neutralize

viruses and bacteria. The detoxifying actions of the liver also require free

radicals to complete the critical process of ridding the body of

organic based toxins like pesticides and herbicides. Although useful under

controlled conditions, free radicals are extremely unstable and can damage cells

if left uncontrolled as caused by infections and toxic exposures. Free radicals

destroy cellular membranes, enzymes, and DNA. For example, inflammation is

usually a site of high free radical production as the body's immune system

fights an infection. The result of excessive amounts of unstable, uncontrolled

and aggressive free radicals in the body causes the condition known as oxidative

stress.

Oxidative stress chips away at healthy cells and is a process, scientists know,

that contributes to a host of diseases and conditions in humans ranging from

rheumatoid arthritis, Alzheimer's Disease, heart disease and stroke to cancer

and aging process. It has also been linked to autoimmune diseases and autism. In

fact, researchers at the University of Pennsylvania School of Medicine have

discovered that children with autism showed signs of abnormal blood-vessel

function linked with damaging levels of oxidative stress as compared to healthy

children.

What are sources of Free Radicals ? Among many other sources, free radicals are

released in the body from exposure to pollutants, toxins and heavy metals, such

as mercury and lead. Inflammation caused by toxins and infections also increase

free radical production.

Free radicals are also released in the body in response to a number of toxins,

including, pesticides, alcohol, radiation, and smoking. Smoking leads to

emphasema as the immune system detects tobacco toxins and produces free radicals

in an attempt to kill

the perceived infection.

Psychological and emotional stress, or even intensive workouts by athletes, can

result in the release of free radicals and can contribute to oxidative stress.

That is because, when the body is under stress, it produces certain hormones

that generate free radicals. Thereafter, the liver must eventually detoxify them

and that process also generates free radicals. While everyone is exposed to free

radicals from a multitude of sources, those living in cities are exposed at much

higher levels due to a greater degree of pollutants and toxins in urban

environments.

Glutathione:

The Body's Pivotal Mechanism to Reduce Oxidative Stress The body maintains a

sophisticated system of chemical and biochemical defenses to control and

neutralize free radicals. There are two groups of antioxidants: chemical

antioxidants and biochemical antioxidants. Chemical antioxidants scavenge free

radicals, that is, they stabilize the unstable free radicals by giving them the

electron they need to " calm down. " The antioxidants are usually consumed or used

up in this process, that is, they sacrifice themselves. Among the most important

chemical antioxidants are glutathione, Vitamins A, E and C, selenium, and zinc.

Vitamin C is known to increase reduced glutathione by increasing NADPH levels

which then convert oxidized glutathione (GSSG)

to reduced glutathione (2 GHSs) by a process called the Meister cycle.

Biochemical antioxidants not only scavenge free radicals but also inhibit their

formation inside the body. They include lipoic acid, melatonin, and cholesterol.

Of all the antioxidants, glutathione appears the most pivotal in reducing

oxidative stress. Made up of three amino acids (cysteine, glycine and glutamic

acid), glutathione is a substrate of the antioxidant enzyme, glutathione

peroxidase, and is the most important because it is critical in removal of

toxins in the liver. While all cells in the human body are capable of

synthesizing glutathione, glutathione synthesis in the liver has been shown to

be most essential in processing toxins o

ut of the body through the P450 detox system of the liver or biliary system.

Glutathione exists in two forms: the reduced state (GSH) and the oxidized or

disulfide state (GSSG). In healthy cells and tissue, more than 90% of the total

glutathione level is in the reduced form (GSH) and less than 10% exists in the

oxidized state (GSSH). The oxidative stress condition is usually monitored by

easuring the level of glutathione and the reduced glutathione/oxidized

glutathione atios by CLIA approved laboratories.

Low levels of glutathione are typically found in people diagnosed with many

illnesses including rheumatoid arthritis, AIDS, cancer, Parkinson's Disease,

immune disorders, and in children diagnosed with autism, as well as with many

other conditions. Adults and children with these conditions are typically found

to have insufficient levels of antioxidants to fight against high levels of free

radicals being produced, a circumstance that causes oxidative stress. It is no

surprise, then, that persons with these conditions arre oxidative stress.

The Benefits of OSR

OSR is a safe and non & #8208;toxic nutritional supplement that dramatically

reduces oxidative stress by significantly increasing the level of glutathione in

most, if not all, cells. Glutathione is the pivotal liver detoxifying

antioxidant, thereby allowing the body to remove harmful free radicals and

restore its own protective mechanisms. OSR is not a precursor for glutathione

synthesis and most likely elicits its effect of increasing reduced glutathione

by its ability to scavenge hydroxyl radical species within

the lipophilic aspects of the cells and mitochondria. OSR is a newly patented

supplement that aids in restoring and maintaining good health from exposure to

pollutants, heavy metals and other toxic sources that produce dangerous free

radicals resulting in numerous harmful conditions in the

body. Current information available from CTI Science Inc (as of 8/16/08),

behaley@....

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