Yahoo! News Story - D-Cycloserine May Improve Autism Symptoms

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D-Cycloserine May Improve Autism Symptoms

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Health - Reuters

D-Cycloserine May Improve Autism Symptoms

Wed Nov 17, 1:54 PM ET

Health - Reuters

NEW YORK (Reuters Health) -

D-cycloserine, a drug that has

shown to reduce symptoms in schizophrenics, appears to

significantly improve social and communication skills in

children with autism, according to the results of a small pilot

study published in the American Journal of Psychiatry.

Yahoo! Health Have questions about your health? Find answers here.

Dr. J. Posey, of the Riley Hospital for Children, in

Indianapolis, Indiana, and colleagues examined the effect of

D-cycloserine on social impairment in 12 autistic children.

Patient outcome was determined by changes in scores on the

Clinical Global Impression scale and Aberrant Behavior

Checklist.

The drug-free subjects received three different doses of

D-cycloserine, each for two weeks. The doses administered were

30 mg per day (low), 50 mg per day (medium) and 85 mg per day

(high). Ten subjects completed the eight-week study.

A significant improvement in the Clinical Global Impression

scale was seen with the medium and high doses. The response

rate with the low dose was 30 percent, and for the medium and

high doses, it was 40 percent.

High-dose D-cycloserine was also associated with

significant improvement on the Aberrant Behavior Checklist

social withdrawal subscale. Symptom severity decreased by 60

percent at this dose.

Given these findings, the researchers conclude that

"further controlled studies of D-cycloserine in autism appear

warranted."

SOURCE: American Journal of Psychiatry, November 2004.

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[May Be SPAM:] Yahoo! News Story - D-Cycloserine May Improve Autism Symptoms

< D-Cycloserine May Improve Autism Symptomshttp://story.news.yahoo.com/news?tmpl=story & u=/nm/20041117/hl_nm/autism_drug_dc

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Health - Reuters

D-Cycloserine May Improve Autism Symptoms

Wed Nov 17, 1:54 PM ET

Health - Reuters

NEW YORK (Reuters Health) - D-cycloserine, a drug that has shown to reduce symptoms in schizophrenics, appears to significantly improve social and communication skills in children with autism, according to the results of a small pilot study published in the American Journal of Psychiatry.

Yahoo! Health

Have questions about your health?Find answers here.

Dr. J. Posey, of the Riley Hospital for Children, in Indianapolis, Indiana, and colleagues examined the effect of D-cycloserine on social impairment in 12 autistic children. Patient outcome was determined by changes in scores on the Clinical Global Impression scale and Aberrant Behavior Checklist.

The drug-free subjects received three different doses of D-cycloserine, each for two weeks. The doses administered were 30 mg per day (low), 50 mg per day (medium) and 85 mg per day (high). Ten subjects completed the eight-week study.

A significant improvement in the Clinical Global Impression scale was seen with the medium and high doses. The response rate with the low dose was 30 percent, and for the medium and high doses, it was 40 percent.

High-dose D-cycloserine was also associated with significant improvement on the Aberrant Behavior Checklist social withdrawal subscale. Symptom severity decreased by 60 percent at this dose.

Given these findings, the researchers conclude that "further controlled studies of D-cycloserine in autism appear warranted."

SOURCE: American Journal of Psychiatry, November 2004.

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Copyright © 2004 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Copyright © 2004 Yahoo! Inc. All rights reserved.Questions or CommentsPrivacy Policy -Terms of Service - Copyright Policy - Ad Feedback

[Guest guest]

I wonder if this drup is for current use on the open market. As of right now, Tim isn't on any meds.....I didn't care for the Concerta, Adderal, Wellbutrin and so on. He is functioning much better without the drugs than with.

[May Be SPAM:] Yahoo! News Story - D-Cycloserine May Improve Autism Symptoms

< D-Cycloserine May Improve Autism Symptomshttp://story.news.yahoo.com/news?tmpl=story & u=/nm/20041117/hl_nm/autism_drug_dc

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Health - Reuters

D-Cycloserine May Improve Autism Symptoms

Wed Nov 17, 1:54 PM ET

Health - Reuters

NEW YORK (Reuters Health) - D-cycloserine, a drug that has shown to reduce symptoms in schizophrenics, appears to significantly improve social and communication skills in children with autism, according to the results of a small pilot study published in the American Journal of Psychiatry.

Yahoo! Health

Have questions about your health?Find answers here.

Dr. J. Posey, of the Riley Hospital for Children, in Indianapolis, Indiana, and colleagues examined the effect of D-cycloserine on social impairment in 12 autistic children. Patient outcome was determined by changes in scores on the Clinical Global Impression scale and Aberrant Behavior Checklist.

The drug-free subjects received three different doses of D-cycloserine, each for two weeks. The doses administered were 30 mg per day (low), 50 mg per day (medium) and 85 mg per day (high). Ten subjects completed the eight-week study.

A significant improvement in the Clinical Global Impression scale was seen with the medium and high doses. The response rate with the low dose was 30 percent, and for the medium and high doses, it was 40 percent.

High-dose D-cycloserine was also associated with significant improvement on the Aberrant Behavior Checklist social withdrawal subscale. Symptom severity decreased by 60 percent at this dose.

Given these findings, the researchers conclude that "further controlled studies of D-cycloserine in autism appear warranted."

SOURCE: American Journal of Psychiatry, November 2004.

Story Tools

Email Story

Post/Read Msgs

Print Story

Ratings: Would you recommend this story?

Not at all 1 - 2 - 3 - 4 - 5 Highly

Special Feature

Is FM Dead?Why satellite radio may be worth a closer listen

Next Story:

Anorexic Girls Bond on Web to Dismay of Doctors (Reuters)

More Health Stories

·

Study: Ultrasound May Help Stroke Victims (AP)

·

Health Tip: Home Water Filters (HealthDay)

·

Medicare to Offer Introductory Physicals in 2005 (American Cancer Society)

·

Britain could become world leader in stem cell research: Blair (AFP)

·

Pfizer's Contraceptive Can Weaken Bones (Reuters)

ADVERTISEMENT

Online Graduate Degrees in Health

•

Online Graduate Degrees in Health

•

Browse All Health Programs

from Yahoo! Education

Copyright © 2004 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon.

Copyright © 2004 Yahoo! Inc. All rights reserved.Questions or CommentsPrivacy Policy -Terms of Service - Copyright Policy - Ad Feedback