Guest guest Posted November 30, 2000 Report Share Posted November 30, 2000 HI! I received the fall issue of the Lied transplant newsletter. One article of interest: Sirolimus (Rapamune) is a new immunosuprressant agent that was recently approved by the FDA to prevent rejection in renal tx. It is also used in patients with liver and liver/small bowel tx. It works differently than cyclosporine " If anyone is interested in the rest of the article I will type out the rest of it. Let me know! Sincerely, , wife of dx 97 PS- this site may be of interest to you: www.nhsnet.org/chrisledoux. This is from the NHS-Lied tx center and there looks like alot of interesting things about psc, etc. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 1, 2000 Report Share Posted December 1, 2000 Hi Greg, here is the rest of the article: It works differently than cyclosporine or prograf, and offers doctors and patients another option to prevent graft rejection. Sirolimus is mostly used with steroids and either cyclosporine or tacrolimus. Due to sirolimus' unigue action mechanism, it has different side effects than cyc and tac. The most common side effects of sir is increased levels of cholesterol and triglycerides. These can be managed by eating a diet low in fat and cholesterol and excersise. Sirolimus can also cause nausea, vomiting and diarrhea, and can make patients more susceptible to infection. Sirolimus interacts with some of the same meds as cyc and tac. These include fluconazole, ketoconazole, itraconazole, erthromycin, claithromycin, diltiazem, verapamil, rifampin, phenytoin and phenobarbital. These meds can cause the sirolimus concentration to be to hight, or too low, so it is important to check with your dr. Sirolimus can interact with grapefruit juice. Notify your dr.. Currently sirolimus is only available as an oral solution, however,a tablet will be available in a few months. (article goes on about how to store and mix it).The FDA also recently approved Gengraf, a generic cyclosporine product. It is an equivalent product to the neoral brand of cyc, but not the sandimmune brand. This med has the same drug interactions and side effects a neoral. Gengraf is available in 25mg and 100mg tablets and some patients prefer the smell of Gengraf to Neoral. The end:) Sincerely, , wife of dx 97 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 1, 2000 Report Share Posted December 1, 2000 Hi Greg, here is the rest of the article: It works differently than cyclosporine or prograf, and offers doctors and patients another option to prevent graft rejection. Sirolimus is mostly used with steroids and either cyclosporine or tacrolimus. Due to sirolimus' unigue action mechanism, it has different side effects than cyc and tac. The most common side effects of sir is increased levels of cholesterol and triglycerides. These can be managed by eating a diet low in fat and cholesterol and excersise. Sirolimus can also cause nausea, vomiting and diarrhea, and can make patients more susceptible to infection. Sirolimus interacts with some of the same meds as cyc and tac. These include fluconazole, ketoconazole, itraconazole, erthromycin, claithromycin, diltiazem, verapamil, rifampin, phenytoin and phenobarbital. These meds can cause the sirolimus concentration to be to hight, or too low, so it is important to check with your dr. Sirolimus can interact with grapefruit juice. Notify your dr.. Currently sirolimus is only available as an oral solution, however,a tablet will be available in a few months. (article goes on about how to store and mix it).The FDA also recently approved Gengraf, a generic cyclosporine product. It is an equivalent product to the neoral brand of cyc, but not the sandimmune brand. This med has the same drug interactions and side effects a neoral. Gengraf is available in 25mg and 100mg tablets and some patients prefer the smell of Gengraf to Neoral. The end:) Sincerely, , wife of dx 97 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 1, 2000 Report Share Posted December 1, 2000 Hi Greg, here is the rest of the article: It works differently than cyclosporine or prograf, and offers doctors and patients another option to prevent graft rejection. Sirolimus is mostly used with steroids and either cyclosporine or tacrolimus. Due to sirolimus' unigue action mechanism, it has different side effects than cyc and tac. The most common side effects of sir is increased levels of cholesterol and triglycerides. These can be managed by eating a diet low in fat and cholesterol and excersise. Sirolimus can also cause nausea, vomiting and diarrhea, and can make patients more susceptible to infection. Sirolimus interacts with some of the same meds as cyc and tac. These include fluconazole, ketoconazole, itraconazole, erthromycin, claithromycin, diltiazem, verapamil, rifampin, phenytoin and phenobarbital. These meds can cause the sirolimus concentration to be to hight, or too low, so it is important to check with your dr. Sirolimus can interact with grapefruit juice. Notify your dr.. Currently sirolimus is only available as an oral solution, however,a tablet will be available in a few months. (article goes on about how to store and mix it).The FDA also recently approved Gengraf, a generic cyclosporine product. It is an equivalent product to the neoral brand of cyc, but not the sandimmune brand. This med has the same drug interactions and side effects a neoral. Gengraf is available in 25mg and 100mg tablets and some patients prefer the smell of Gengraf to Neoral. The end:) Sincerely, , wife of dx 97 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 1, 2000 Report Share Posted December 1, 2000 Thanks, ... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 1, 2000 Report Share Posted December 1, 2000 Thanks, ... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 1, 2000 Report Share Posted December 1, 2000 Thanks, ... Quote Link to comment Share on other sites More sharing options...
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