Guide to Klaire Labs Probiotics

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The following guide to Klaire Labs probiotics was provided by

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Lab products. For more details, please visit the web site or contact

directly. There is standing 10% off any order. Just provide this

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GUIDE TO KLAIRE LABORATORIES PROBIOTICS

Klaire Laboratories has an exceptional line of " dairy free "

and " maltodextrin free " probiotics designed for the exquisitely

sensitive individual. Klaire Laboratories provides innovative

probiotic formulations utilizing extensively researched strains, with

clinically proven health benefits and ones that have the ability to

adhere and colonize the gastrointestinal tract.

Klaire Laboratories is in the forefront of exploring current trends

in probiotic research and in partnering with Chr. Hansen, recognized

in the industry as the world's probiotic experts. Five of our

microorganism formulations contain Chr. Hansen's extensively

researched probiotic strains including BB-12 (Bifidobacterium

bifidum) and (LA-5) Lactobacillus Acidophilus.

An editorial, published in TIME Magazine 12/28/98 entitled " Healthy

Germs " , discusses some of the research behind, as well as benefits

of, these probiotic strains. If you have questions about the use of

probiotics, please ask your physician. If your physician is

unfamiliar with the use of probiotics, have them contact us and we

will put them in touch with Doctors at Klaire Laboratories to answer

their questions.

Suggested Usage for most products listed except as noted: As a

dietary supplement, one or two capsules daily or as directed by a

physician. For children under the age of two, consult your physician

for dosage. More Info: More information can be found at

http://www.vitallifevitamins.com

The statements in this document have not been evaluated by the Food

and Drug Administration. The products are not intended to diagnose,

treat, cure, or prevent any disease.

KLAIRE PROBIOTICS PRODUCT OVERVIEW

Vital-Dophilus PlusÔ: L. acidophilus, L. rhamnosus

Many researchers now believe the myriad health benefits of L.

acidophilus are also attributable to L. rhamnosus. To make a more

complete formula, we've added L. rhamnosus to our popular acidophilus

formula. These two species are perhaps the most important

Lactobacilli in the small intestine. Vital-Dophilus is an excellent

choice for those wanting something extra out of their acidophilus

supplement.

Vital-PlexÔ: L. acidophilus, L. rhamnosus, E. faecium, B. bifidum

The " doctor's choice. " This probiotic has become so popular with

health professionals over the years because of the proven therapeutic

value of E. faecium. This species shows strong activity against a

variety of pathogenic organisms. In several studies it has proven

resistant to a wide variety of antibiotics and, in one study, proved

more effective than L. acidophilus in shortening the duration of

diarrheal episodes. E. faecium is a natural resident of the human

intestinal tract. Our Vital-Plex, balanced to cover both the small

and large intestine, is an excellent choice for those taking

antibiotics, or for acute gastrointestinal conditions.

Pro-5: L. rhamnosous, L. acidophilus, B. lactis, Streptococcus

thermophilus, L. bulgaricus

Indications: Pro-5 is a blend of five extensively researched strains

of friendly bacteria: Lactobacillus rhamnosus, Lactobacillus

acidophilus, Bifidobacterium lactis, Streptococcus thermophilus, and

Lactobacillus bulgaricus. These strains maintain viability in acidic

environs as may be found in the stomach, and are tolerant to

compounds found in the intestine such as bile. Clinical research has

documented the usefulness of the probiotic strains in Pro-5 as an

adjunct to the management of gastrointestinal disorders, including:

Antibiotic-associated decrease in friendly bacteria, Prevention of

Clostridial colonization, Traveler's diarrhea, Diarrhea associated

with rotaviral gastroenteritis, Acute non specific diarrhea,

Constipation, Enhancement of immune response to rotaviral infection

and adjuvant to rotavirus vaccine, Alleviation of intestinal

inflammation and permeability, Amelioration of food allergies,

especially lactose intolerance, Enhancement of the intestine's

immunological barrier function, Intestinal production of short-chain

fatty acids.

Suggested Usage: As a dietary supplement, take one capsule daily.

For intensive usage, two capsules a day may be used for two weeks or

more, in order to stabilize and balance intestinal flora, followed by

a maintenance dosage of one capsule daily. Children under 30 lbs

should be given 1/3 to 1/2 the recommended adult dosage. The capsules

may be opened and mixed with milk, yogurt, or other cool or room

temperature foods. For children under the age of two, consult your

physician for dosage.

Pro-Biotic ComplexÔ: L. acidophilus, B. bifidum,

Fructooligosaccharides (FOS)

Indications: This formula lends a greater degree of support to the

large intestine while still providing support for the small

intestine. As we age, Bifidobacteria in the colon tend to decline,

while other, more undesirable bacteria proliferate. To reestablish

the essential flora of the large intestine, we've added B. bifidum,

an important member of the Bifidobacteria, and FOS, a probiotic

proven to substantially increase numbers of Bifidobacteria. The Pro-

biotic Complex is best utilized for those requiring higher amounts of

these two primary " resident " microorganisms.

Vital-Immune BioticÔ: L. casei, L. rhamnosus, L. acidophilus, B.

longum

Indications: Important studies have demonstrated the immune-enhancing

properties of lactic acid bacteria. L. casei has been named in a

significant number of these studies. L. rhamnosus, until recently,

was subsumed under the heading of L. casei and likely possesses

similar immune-potentiating characteristics as L. casei. A strain of

L. rhamnosus was also recently shown to mitigate the effects of food

allergy on infants with atopic dermatitis -- a reduction in

intestinal inflammation was considered a key factor in bringing about

the improvements observed. Our Vital-Immune Biotic contains these

two key Lactobacillus species, plus L. acidophilus and an important

Bifidobacterium, for a wide range of health benefits.

Vital-10Ô: L. acidophilus, L. rhamnosus, L. delbrueckii subsp.

bulgaricus, L. plantarum, L. salivarius, L. brevis, L. casei, B.

infantis, B. bifidum, Strep. thermophilus.

Indications: Containing the greatest variety of lactic acid bacteria

of all our formulas, Vital-10 most closely mimics the diverse

community of organisms found in the human gastrointestinal tract.

Numerous studies have shown probiotic organisms to be effective in

reducing lactose intolerance, relieving constipation, preventing

gastrointestinal infections, enhancing immune activity and, in some

studies, reducing cholesterol.

Culturelle Lactobacillus GG: Lactobacillus GG.

Indications: Culturelle is the only probiotic supplement containing

Lactobacillus GG. In 1985, Drs. Sherwood Gorbach and Barry Golden

isolated a new strain of Lactobacillus that appears to be ideal for

use in humans. The strain, named Lactobacillus GG (after the surnames

of its inventors), is resistant to stomach acid and bile, allowing it

to survive its passage through the digestive tract and reach the

large intestine intact. Once there it shows an exceptional ability to

adhere to the intestinal mucosa and proliferate.

Usage: As a dietary supplement, take one capsule daily. For

intensive usage, two capsules a day may be used for two weeks or

more, in order to stabilize and balance intestinal flora, followed by

a maintenance dosage of one capsule daily. Children under 30 lbs

should be given 1/3 to 1/2 the recommended adult dosage. The capsules

may be opened and mixed with milk, yogurt, or other cool or room-

temperature foods. For children under the age of two, consult your

physician for dosage.

PROBIOTIC BACTERIA STRAINS

When purchasing probiotics be certain that the strains of bacteria

are documented, which means that it is the same strain over and over

again, which has been researched for its effectiveness. If a company

doesn't have a documented strain you may get something that is not

effective. All Klaire Labs probiotics use documented strains of

bacteria.

The food source for microorganisms is also important. Klaire Labs

uses inulin (from Chicory aka lettuce family) which provides a

natural food source for the microorganisms of a highly hypoallergenic

nature and is able to survive the digestive tract and allows the

microorganisms to flourish in the colon. That is where the inulin is

finally broken down by the organisms.

BIFIDOBACTERIUM BIFIDUM

B. bifidum is a prominent probiotic microorganism that takes up

residence primarily in the mucous membrane lining of the large

intestines and the vaginal tract. B. bifidum prevents the

colonization of invading pathogenic bacteria by attaching to the

intestinal wall, crowding out and taking nutrients from these

unfriendly bacteria and yeast. B. bifidum produces lactic and acetic

acids, which lower the intestinal pH and further inhibit the

undesirable bacteria from growing. Research on Bifidobacteria has

established that these organisms enhance the assimilation of minerals

such as iron, calcium, magnesium and zinc.

BIFIDOBACTERIUM INFANTIS

Bifidobacterium infantis is an important organism shown to stimulate

production of immunomodulating agents such as cytokines.

Bacteriocidal activity is also observed against such pathogens as

Clostridia, Salmonella, and Shigella.

BIFIDOBACTERIUM LONGUM

Bifidobacterium longum is a very abundant organism found in the large

intestine. It plays a role in preventing the colonization of invading

pathogenic bacteria by attaching to the intestinal wall and crowding

out unfriendly bacteria and yeast. Along with other microorganisms,

it produces lactic and acetic acids that lower the intestinal pH and

further inhibit the undesirable bacteria. B. longum has, in clinical

studies, been found to reduce the frequency of gastrointestinal

disorders (diarrhea, nausea, etc.) during antibiotic use.

ENTEROCOCCUS FAECIUM

E. faecium has been shown to be important in the nutritional support

of diarrheal diseases, especially in cases where pathogenic microbes,

such as rotavirus, invade the bowel. This particular organism only

transiently colonizes the GI tract. A recent study indicated that an

E. faecium-containing yogurt was able to significantly lower LDL

cholesterol. E. faecium is safe, and has been researched extensively

by the World Health Organization.

FRUCTOOLIGOSACCHARIDES & INULIN

FOS and inulin are non-digestible oligosaccharides that help promote

the growth and activity of friendly bacteria in the intestinal tract.

These oligosaccharides are non-caloric compounds that can not be

broken down by our digestive enzymes and therefore do not adversely

affect blood sugar levels. Research has shown that both FOS and

inulin enhance the growth of lactic bacteria, especially

Bifidobacteria, and inhibit the growth of a variety of undesirable

organisms.

LACTOBACILLUS ACIDOPHILUS

L. acidophilus is one of the most important microorganisms found in

the small intestines. It is known to implant itself on the intestinal

wall, and in the lining of the wall of the vagina, cervix, and

urethra. It performs many critical functions including inhibiting

pathogenic organisms and preventing them from multiplying and

colonizing.

It is well documented that L. acidophilus produces natural

antibiotics like lactocidin, acidophilin, etc., which enhances

resistance or immunity. L. acidophilus has known antimicrobial

activity against Staphylococcus aureus, Salmonella, E.coli and

Candida albicans.

LACTOBACILLUS BREVIS

Lactobacillus brevis is a lactic acid producing organism important in

the synthesis of vitamins D and K.

LACTOBACILLUS BULGARICUS

Lactobacillus bulgaricus is considered a transient microorganism that

does not implant in the intestinal tract, but still provides an

important protective role. This organism is used extensively in the

commercial fermentation of yogurt. Production of lactic acid by the

bacterium provides a favorable environment for the growth of other

lactobacilli and bifidobacteria residing in the intestine. Studies

indicate that certain strains of L. bulgaricus stimulate production

of interferon and tumor necrosis factor, thus establishing a

potential role in modulating the immune system.

LACTOBACILLUS CASEI

Lactobacillus casei is closely related to the L. rhamnosus and L.

acidophilus strains with some of the same immuno-modulating effects

as other Lactobacilli. L. casei has several health-promoting effects

provided through the production of bacteriocins, compounds that

inhibit the growth of pathogenic bacteria in the small intestine.

LACTOBACILLUS PLANTARUM

Lactobacillus plantarum secretes the naturally occurring antibiotic

lactolin, and is also known to have the ability to synthesize the

amino acid L-lysine, which has beneficial anti-viral activities. L.

plantarum also produces glycolytic enzymes shown to degrade

cyanogenic glycosides and is effective in eliminating nitrate while

producing nitric oxide. This probiotic can preserve key nutrients,

vitamins, and antioxidants, eliminate toxic components from food, and

eradicate pathogens such as S. aureus from fermented food. L.

plantarum-fermented oat given to healthy volunteers significantly

reduced a number of potential pathogens in the gut.

LACTOBACILLUS RHAMNOSUS

Lactobacillus rhamnosus is primarily found in the small bowel and

vaginal tract and is beneficial in inhibiting those bacteria involved

in vaginal and urinary tract infections. L. rhamnosus is very

prolific in growth, has a high tolerance (resistance) to bile salts,

adheres to the intestinal mucosa, and protects the intestinal tract

against the invasion of harmful microorganisms. Additionally, this

organism favorably affects lactose intolerance. A recent double-

blinded, placebo-controlled study suggests that this probiotic

bacteria may down-regulate hypersensitivity reactions and intestinal

inflammation in patients with atopic eczema and food allergies. L.

rhamnosus has been found to have significant benefits in the

nutrition and well-being of infants and in the elderly. According to

research with this strain, administration of L. rhamnosus is most

helpful in inhibiting early intestinal infections in infants. This

species of Lactobacillus does not only colonize, acidify and protect

the small intestine, but it can quickly establish itself in the large

intestine, inhibit the growth of streptococci and clostridia, create

anaerobic conditions which favor the implantation of bifidobacteria,

and produce biologically desirable lactic acid.

LACTOBACILLUS SALIVARIUS

Lactobacillus salivarius is important in normalizing the gut flora of

those dealing with chronic bowel conditions and shows potential as an

effective inhibitor of H. pylori, an organism associated with the

occurrence of ulcers.

STREPTOCOCCUS THERMOPHILUS

Streptococcus thermophilus, in combination with L. bulgaricus, is

used commercially to produce yogurt. This organism is known to be

efficient in breaking down lactose by producing the enzyme lactase.

Those who are lactose-intolerant may be greatly helped by

supplementation with this particular strain. Cytokine production is

stimulated in tissue cultured cells by this bacterium.