Fwd: Lower your risk of cancer with selenium

[Guest guest]

Hi all,

This may well be of interest to some one.

Larry

Health Sciences Institute e-Alert

29 July 2005

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Dear Larry

For several years we've been telling you about the advantages of selenium - a

naturally occurring mineral with powerful antioxidant properties. In e-alerts

we've told you about studies that have shown how a sufficient selenium intake

may lower the risk of prostate, breast, colorectal and lung cancers.

Now a US study from Indiana University Cancer Centre and Indiana University

School of Medicine has explored the theory that selenium activates an important

tumour-suppressing gene called p53. Scientists estimate that the p53 gene is

mutated in as much as 70% of all cancers.

In experiments performed on human lung cancer cells, the Indiana researchers

used selenomethionine, the major component of selenium, to treat cells that

contained p53 genes, and other cells that were deficient in p53. Results showed

conclusively that selenomethionine not only activated the p53 protein, but also

protected cells containing p53. Based on these findings, the researchers

speculate that selenium therapy may act as a cancer preventive by enhancing the

vitality of p53 genes. When the p53 genes function properly, cells are more

likely to repair the DNA damage that may promote cancer.

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Selenium - the versatile antioxidant

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In addition to its excellent cancer-fighting abilities, many studies have shown

that selenium's antioxidant properties may also fight autoimmune disorders and

help increase insulin efficiency. Other research has concluded that it may be

able to stop viruses from mutating and becoming more potent. US HSI Panelist Dr

Milner, has used selenium for many years in his cancer protocol to reduce

the complications from chemotherapy and to increase general longevity.

Clearly, the importance of selenium in our diets can't be overstated. Plant

foods are the major dietary sources, but the amount of it in any plant depends

on the selenium content of the soil it's grown in. For instance, soils on the

high plains of North America have high amounts of selenium, while the soil in

much of China contains low amounts. Soils in the UK and Europe generally also

have low levels. So while garlic tends to contain good amounts of this mineral,

the amounts vary depending on the soil the garlic is grown in.

Selenium intake in the UK has fallen over the last 25 years and this is largely

due to the reduction in the import of high selenium wheat from North America.

The UK reference nutrient intake (RNI) for selenium is 75 and 60 ug/day for

adult males and females respectively.

Some countries experiencing a similar decline, have brought in special measures.

For example in Finland an agricultural fertilisation programme has been

implemented in order to raise cereal selenium concentrations and boost dietary

intakes. Since this programme was implemented in 1985, the selenium intake in

Finland has more than tripled and the prevalence of coronary heart disease and

some forms of cancer has fallen.

The UK reference nutrient intake (RNI) for selenium is 75 and 60 mcg/day for

adult males and females respectively. The Brazil nut is the undisputed champ,

with one ounce containing as much as 840 micrograms (mcg) - well over the

government recommended daily intake. Bread, fish, meat and eggs are also good

food sources. However, Dr. L. , the author of the Indiana study,

noted that the average diet probably falls short of 50 mcg per day. Furthermore,

Dr. believes that in order to reap the cancer preventive qualities of

selenium, intake needs to be around 200 mcg per day.

In other words, if you can't or don't want to add a quarter ounce of Brazil nuts

to your daily diet, you might want to add selenium to your supplement regimen.

But you should also be aware that too much can be toxic. By too much, I mean an

intake of more than 2,500 mcg per day. So if you currently take a multi-vitamin,

check to see if you're already getting some amount of selenium. You may be

getting enough, but the chances that you're getting near a dangerous dose are

extremely slim.

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. . and another thing

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A leading drug manufacturer has been accused of aggressively marketing a heart

failure drug despite concerns over its safety.

Nesiritide is produced by Scios, a subsidiary of & , and is

prescribed as a treatment for decompensated congestive heart failure.

An article in the Journal of the American Medical Association in April claimed

that patients treated with nesiritide were 80 per cent more likely to die in the

month following treatment than those who were treated with traditional drugs for

heart failure.

And now a leading cardiologist, Dr Topol of the Cleveland Clinic Lerner

College of Medicine (US), writes in the New England Journal of Medicine this

week that the manufacturers are ignoring these safety concerns and continuing to

market the drug aggressively.

Dr Topol writes: 'How can a drug that is associated with higher rates of both

renal dysfunction and death than placebo - and that costs 50 times as much as

standard therapies and for which there are no meaningful data on relevant

clinical end points - be given to more than 600,000 patients and be promoted

throughout the United States for serial outpatient use, an indication not listed

on the label?'

He concludes that nesiritide 'has not yet met the minimal criteria for safety

and efficacy' and that 'until a trial definitively proves that this drug reduces

the risk of death or repeated hospitalisation for heart failure, there will be

questions about the appropriateness of the drug's use or even commercial

availability'.

Once again, the underhand tactics of mainstream medicine astound me.

Until tomorrow,

UK Editor

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