Re: Re: DETOXIFICATON IN AUTISTIC SPECTRUM DISORDER Kane, Ph.D.

June 6, 2001

According to good science, no it can't. It's unfortunate but there are a

number of misconceptions and mistakes in this paper. DMSA causing seizure

activity is one of them. Yes, it can, but should that be an indictment of

the chelator or something a little deeper. Zinc has been shown to cause

seizures, as has calcium, sodium, potassium and even magnesium. Do we stop

taking them because of that? Of course not! Dr. Jim Laidler, has reviewed

over 700 papers and views DMSA as safe. Dr. Holmes, Dr. Andy Cutler, and

100's of other clinicians and scientists view DMSA and ALA as safe. In

spite of that, are we to now deem DMSA and ALA as unsafe? Come on now. We

could go on and on but its not worth it.

Poor science, without any solid references lead to a paper we should all

disregard.

Just my opinion.

In health,

Mark Schauss

www.cellmatewellness.com

[ ] Re: DETOXIFICATON IN AUTISTIC SPECTRUM DISORDER

Kane, Ph.D.

> --So, does this mean that mercury can be removed from the body and

> the brain without DMSA and ALA and using supplements and dietary

> changes?

>

> - In @y..., carltonl@c... wrote:

> > Bodybio, 45 Reese Road, Millville, NJ 08332

> > Ph:856-825-8338

> > Web:Bodybio.com

> >

> > Recently, it has been proposed that Autistic Spectrum Disorder

> > (ASD)may be the aftermath of exposure to mercury such as ethly

> mercury

> > used as a preservative, thimerosal, in pediatric vaccinations.

> > Inappropriate use of the drug DMSA and lipoic acid has been utilized

> > in an attempt to detoxify children with ASD which has led to such

> side

> > effects as seizures, increased self-stimming, and compromised CNS

> > function in some children The use of chelating agents such as DMSA

> can

> > increase the entry of mercury into motor axons (neurons)as a result

> of

> > chelator-induced elevated circulating Hg (Ewan K. and Pamphlett, R

> > Neurotoxicology 17:2:343-350, 1996). Furthermore, it appears that

> > lipoic acid can create tissue redistribution of mercury as

> decreasing

> > Hg levels in the kidney (the organ accumulating Hg most

> > abundantly)increase Hg concentrations of Hg in blood, brain, lung,

> > heart, muscle and liver (Gregus Z et al, Toxicology and Applied

> > Pharmacology 114:88-96, 1992). Biological physicians throughout the

> US

> > have reported MS symptoms in adults and intractable seizures in

> > pediatric pts with high dose and extended use of DMSA (2,

> > -dimercaptosuccinic acid) Chemet or Succimer. DMSA is a mixed

> > disulfide in which each of the sulfur atoms is in disulfide linkage

> > with a cysteine molecule forming water soluble chelates which

> > increases the urinary excretion of lead. It's usefulness in regard

> to

> > the chelation of Hg has not been demonstrated in medical trials

> > according to the Physicians Desk Reference. Extended use of DMSA can

> > cause mild to moderate neutropenia with increased SGOT, SGPT,

> Platelet

> > count, Cholesterol, Alkaline Phosphatase and blood Urea Nitrogen

> > (BUN). Adverse reactions to DMSA include ataxia, convulsions, rash,

> > nausea, diarrhea, anorexia, headache, dizziness, sensorimotor

> > neuropathy, decreased urination, arrhythmia, and infection. Zinc

> > excretion doubles during the administration of DMSA. Patients must

> be

> > kept hydrated as renal function can be compromised. A majority of

> > children with ASD present with dehydration, billary congestion and

> > constipation/ or impaction with diarrhea overflow. If these medical

> > issues are not addressed then the side effects would be exacerbated.

> > One suggestion was a time released DMSA, but it appears that this

> > merely impairs the absorption of DMSA further and thus offers lower

> > exposure to the drug. Proposals of the use of DMSA for 7 days on, 7

> > days off or 3 days on, 4 days off for an extended period of time (up

> > to 6 months to 2 years) are unacceptable and may lead to very

> serious

> > side effects. To wait 6 months to 2 years to see results is

> > preposterous in the face of young children with extremely

> compromised

> > CNS function which may equate to a lost window of time in which the

> > child's disturbed brain chemistry could have been addressed with

> > appropriate nutritional intervention. The PDR suggests 10 mg/kg of

> > body weight of DMSA in children every 8 hours for 5 days for lead

> > toxicity. Initiation of therapy at high doses is not recommended.

> > Frequency of administration is reduced to 10 mg/kg every 12 hours

> for

> > an additional two weeks of therapy. A course of treatment lasts 19

> > days. Repeated courses may be indicated if verified by laboratory

> > testing that the heavy metal has not been mobilized by a minimum of

> > two weeks between courses is recommended. No controlled clinical

> > trials have been conducted with DMSA with other heavy metals. Safe

> > clinical protocols must be established for removing Hg

> > (Klinghardt,Kane 2000,2001 and in press)so that clinicians have a

> > clear understanding of detoxification, especially in potential ASD

> > cases where the Hg may be intracellular and the exposure many years

> > prior. Approaching the fragile brain architecture of young children

> > with autism, PDD, and seizure disorders brings abut tremendous

> > responsibility in protecting the children from invasive intervention

> > that risk alteration in CNS function. First, a determination must be

> > made if, in fact, there is a heavy metal burden, and if so,

> > specifically which heavy metals are involved such as lead, cadmium,

> > mercury. Clearing heavy metals may be approached by first

> > reestablishing the mineral base, supporting billary function/

> > digestion, insuring the patient is properly hydrated (children with

> > ASD are frequently dehydrated), and supporting hepatic/renal

> function

> > and metabolism. Fecal impaction must be cleared, lipid aberrations

> > identified and fatty acid/ membrane function stabilized and billary

> > congestion must be addressed through the use of a gall bladder

> flush,

> > high fat diet, CCK, and butyrate. One must be relatively healthy to

> > sustain the process of detoxification. Once metabolic stability is

> > established physicians often find that gentle biological

> interventions

> > clear heavy metal burdens without the need for medication that holds

> > the potential risk of negative side effects or merely redistribution

> > of heavy metals.

> > Adult population of patients with heavy metal toxicity present with

> > significant suppression of omega 6 arachidonic acid and a

> significant

> > elevation of very long chain fatty acids (Kane) as the cellular

> impact

> > of heavy metals burdens block receptor sites such as G proteins and

> > ultimately suppress the beta oxidation of lipids and cellular

> > respiration children with ADS consistently present with an elevation

> > of VLCFA's however, red cell lipid levels of arachidonic are

> variable,

> > elevated in some patients while deeply suppressed in others. Dietary

> > intervention must be considered as administration of marine oils

> > suppresses omega 6 and structural lipids through suppression of

> > arahidonic acid would occur due do to oral use of omega 3 fatty

> acids.

> > To balance human lipid metabolism it is crucial to stabilize omega 6

> > fatty acids and the lead eicosanoid Arachidonic acid before

> > introducing omega 3 lipids. Clinicians are often met with poor

> patient

> > outcomes when merely administering omega 3 lipids without first

> > introducing omega 6 fatty acids, stabilizing the structural lipids,

> > and supporting the digestion of fats with bile salts and lipase.

> > The impact of Hg upon human health was brought to light in the

> > mid-50's with the Minamata disaster in Japan. As noted in the

> > documentary " Message to Minamata to the World " the impact of Hg is

> > devastating, most prominently to the CNS. Interestingly, autistic

> > behavior can be observed in the documentary of Minamata children in

> > the original footage after the disaster. In 1993, Kane found an

> > interesting correlation in the literature between autism and Hg with

> > the occurrence of autism presenting in adulthood occurring in Japan.

> > The presentation of autism in these individuals was linked to

> > ornithine transcarbamylase deficiency, the most common urea cycle

> > defect. Damage to this enzyme can occur with exposure to mercury.

> Low

> > levels of ornithine transcarbamylase (OTC) leads to states of

> > hyperammonemia, seizures, and stroke. The enzyme OTC controls

> ammonia,

> > critical issues in states of epilepsy and autism. The often spacy,

> > confused behavior " brain fog " that is frequently observed in these

> > disorders may be attributed to states of hyperammonemia as ammonia

> > reaches the brain. Suggested treatment of mildly suppressed levels

> of

> > OCT includes sodium benzoate and phenylacetate. However, Kane and

> > other clinicians have observed positive clinical usefulness of Ca/Ma

> > butyrate, digestive intervention targeted to billary flow,

> appropriate

> > buffers, an stabilization of electrolytes and the trace mineral

> base.

> > Dietary or environmental sources of mercury must be removed

> > immediately. These would include fish (tuna)(fish simply must be

> > removed as would swordfish, shark, and other large body fish) and

> fish

> > oils (verify the purity of fish oils) consumed such as Nordic

> > Naturals, Tyler Encapsulations or Oakmont Labs. Because mercury is

> > used as a preservative, thimerosal, it may be in ear or eye drops

> and

> > these sources will need to be avoid as well. Amalgam filling also,

> > offer a significant exposure (vapor)to mercury as would working in

> an

> > environment as a as a dental office.

> > Low fat diets impair billary flow which would be contraindicated in

> > attempting to clear toxicity as bile is paramount to cleansing the

> > body and getting toxic metals into the fecal matter. A pure, organic

> > varied diet of vegetables, fruit, legumes, seeds, nuts, eggs, whole

> > grains (gluten-containing grains are best avoided), butter,

> > unprocessed oils, free range poultry, wild game should be

> emphasized.

> > Once the mineral base is firmly established with the use of oral

> > electrolytes, trace minerals, nutrient dense foods and digestion is

> > normalized and issues such as dehydration and constipation are

> > resolved appropriate testing and treatment for detoxification may

> > commence with gentle, natural modalities that unload cellular

> toxicity

> > safely.

> > A special session at the May 2001 Bodybio Medical Conference

> convened

> > to review present assessment and treatment of Mercury Toxicity in

> > Autism. The consensus of all present was that the use of DMSA was

> > unsafe in their clinical experience which was extensive. Rather,

> they

> > relied upon building a firm nutritional foundation and using natural

> > chelators to detoxify children. A few physicians used DMPS orally in

> a

> > challenge dose to verify mercury toxicity, but not as treatment. No

> > side effects had been noted in challenge dosing. After thorough

> > research of the literature Dr.Kane proposed a 3-phase nutritional

> prep

> > for detoxification followed by IV glutathione push twice weekly. All

> > present agreed that this was a safe mercury detox intervention that

> > would be explored in detail in each of their satellite clinics.

> >

> > I typed this in myself, so please excuse any typos.

> > Best, Forrest's Mom

>

> =======================================================

>

June 6, 2001

The PDR lists seizures as a possible side effect. Guess Mark didn't read that

before he posted. It appears to be rare, but was significant enough to be

included in the PDR. Guess it IS an indictment of the chelator or something a

little deeper THAT THE CHELATOR DOES, to expound on Mark's statement below.

Magnesium usually raises the seizure threshold, not lowering it, although

anything is possible when electrolytes are out of balance- that is one of the

first things doctors look at when a previously normal mentation person gets

confused. This can also be a source of seizure activity and a chem panel is

one of the first things that is done in a workup of a patient who has started

having seizures (along with an EEG of course).

Since I have been researching this for a while myself, I know there aren't

700 papers on DMSA, and I doubt there are 700 papers on chelation, although

there are a lot. (Perhaps Mark is exaggerating a bit?)

I know of several physicians who have found problems with DMSA, (including

seizures) including the one we were seeing when tried it. I'm sure

problems are underreported in this kind of treatment, just like there are in

vaccine reactions.

Since DMSA seemed to be the best choice at present for giving the kids, I

have sat back and kept my mouth shut.

Jim (Laidler) says that there may well be other reasons why DMSA helps many

of the kids, quite likely in other ways besides mercury excretion.

I just happen to believe, myself, personally, that there may be safer ways to

do some of these things than using DMSA. Again I plan to use the IV Vit. C/

Glutathione approach as soon as I have the money. And in the meantime, I am

getting my son's gut healed and boosting his natural detox systems. And you

know what... his speech has dramatically increased in the past week! (And I

am not using either DMSA or ALA.)

Ruth,

's mom

Ruth

<<Message: 21

Date: Wed, 6 Jun 2001 09:16:29 -0700

From: " Mark Schauss " <schauss@...>

Subject: Re: Re: DETOXIFICATON IN AUTISTIC SPECTRUM DISORDER Kane,

Ph.D.