Guest guest Posted May 1, 2011 Report Share Posted May 1, 2011 I am interested in people's experience of GABA-related drugs, I haven't tried it myself. I take a range of blood pressure and other medications as it is, and I wouldn't take anything without consulting my GP. Even the prescribed medications put me in hospital once because my BP went too low. When you say " I like GABA " , what specifically do you like? Does it make you calmer, lower your 4S, or something else? > > > > Has anyone here tried Picamilon? It is an over-the-counter dietary supplement that contains GABA, which is an inhibitory neurotransmitter. There is some interesting research to suggest that a deficit in GABA plays a role in the sensory problems of people on the autism spectrum. > > > > I have no experience of this drug at all, but was just intrigued to see if anyone had ever used or tried it, even for other conditions. I have absolutely no idea whether it would help 4S and *I am not urging anyone to go out and try it*: I haven't read about its side-effects. Just wondering if anyone has heard of it. > > > > Some more info: > > > > https://secure.wikimedia.org/wikipedia/en/wiki/Picamilon > > https://secure.wikimedia.org/wikipedia/en/wiki/Anxiolytic#Herbal_treatments > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 1, 2011 Report Share Posted May 1, 2011 Yep. That's EXACTLY why I wrote: " *I am not urging anyone to go out and try it* " I am glad that you weighed in with some extra info, though. I understand the general issues about taking care with over the counter preparations, but not the details about specific substances. Like you, I want to know what works (if anything) regardless of how it was obtained. But I don't recommend turning your body into a test tube for experimenting. > > neuroscientist here. can i be a wet (or, at least damp) blanket? > > it's a GABAergic drug, increasing the amount of inhibitory neurotransmitter in your brain (stops neurons from firing). this one doesn't appear to be very selective so could have widespread unintended effects. maybe try a prescription, because those drugs are probably much safer and more effective (this one was created by soviet scientists? scary). it's too bad we can't get the best ones over the counter but GABAergic drugs can be dangerous (overdose, side effects, dependence risk, withdraw) so someone with more experience with them may be able to help control dosage, monitor side effects, etc. > > this is very helpful: > http://www.drugs-forum.com/forum/showthread.php?t=112788 & highlight=phenazepam > > i would be interested to know, though, if anyone has found help from this kind of drug, either over, under, or behind the counter? e.g. benzodiazepines? i'm going to a shrink soon and will let you know the outcome... > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 1, 2011 Report Share Posted May 1, 2011 I have to some degree. You will have to excuse the spelling here as I don't have the packet on me but I've taken frisium and found its effects to be interesting. In short I was given this drug for panic attacks ( which I have never felt I've had, just had a racing heart (IST) ) I haven't taken the drug much but one day I was having a hard time with my anger and 4s in that order. After failing with mind tricks, (will power, BWE, CBT) I decided to try the frisium. Within 20 minutes my mood was calmer and so too then was my sensitivity to 4s. I have not tried to use the drug just for 4s but might next time I need it. I'll report back on that and also put it under the medication section of the private forum. Do you know much about lyrica? I have found that when I am on that I am far less likely to be triggered. Totally different drug I know. > neuroscientist here. can i be a wet (or, at least damp) blanket? > > it's a GABAergic drug, increasing the amount of inhibitory neurotransmitter > in your brain (stops neurons from firing). this one doesn't appear to be > very selective so could have widespread unintended effects. maybe try a > prescription, because those drugs are probably much safer and more effective > (this one was created by soviet scientists? scary). it's too bad we can't > get the best ones over the counter but GABAergic drugs can be dangerous > (overdose, side effects, dependence risk, withdraw) so someone with more > experience with them may be able to help control dosage, monitor side > effects, etc. > > this is very helpful: > http://www.drugs-forum.com/forum/showthread.php?t=112788 & highlight=phenazepam > > i would be interested to know, though, if anyone has found help from this > kind of drug, either over, under, or behind the counter? e.g. > benzodiazepines? i'm going to a shrink soon and will let you know the > outcome... > > > > >> >> Has anyone here tried Picamilon? It is an over-the-counter dietary >> supplement that contains GABA, which is an inhibitory neurotransmitter. >> There is some interesting research to suggest that a deficit in GABA plays >> a role in the sensory problems of people on the autism spectrum. >> >> I have no experience of this drug at all, but was just intrigued to see if >> anyone had ever used or tried it, even for other conditions. I have >> absolutely no idea whether it would help 4S and *I am not urging anyone to >> go out and try it*: I haven't read about its side-effects. Just wondering >> if anyone has heard of it. >> >> Some more info: >> >> https://secure.wikimedia.org/wikipedia/en/wiki/Picamilon >> https://secure.wikimedia.org/wikipedia/en/wiki/Anxiolytic#Herbal_treatments >> > > > -- Sent from my mobile device Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 2, 2011 Report Share Posted May 2, 2011 Yes - exactly. Makes me calmer. Did more reading yesterday - as much as I can understand it, the Taurine (and a splashh of B6 would help too) gets the cystein thru the blood-brain barrier to control actions of inhibitory transmitters in the amygdala. Taurine is an amino acid derivative produced by cystein and you have to get thru the BBB in order for the brain to synthesize taurine and GABA. You're right: it would be best to find the target and direct efforts there instead of flooding our systems with who-knows-what. More research has led me to the following thoughts: The diencephalon: thalamus, hypothalamus, pituitary, medial geniculate = hearing. OR primary auditory cortex is frontal lobe and perception of sound is right posterior temporal gyrus. Temporal lobe controls hearing and emotional memory. When cats had stim on lateral hypothalamus, they went into sham rage. - OR - Epilepsy w/ auditory features is a Lateral Temporal Lobe seizure sometimes caused bt hippocampal sclerosis OR REFLEX EPILEPSY audiogenic seizure in mice due to magnesium deficiency/depletion. Magnesium-pyrrolidone-2carboxylate. B6 w/ ATaMg dose 5mg/kg plus taurine should fix it if that's yt our problem and you're a mouse. OR if we want to go the adrenal route Hearing - to hypothalamus - to amygdala - if problem perceived, sends signals to autonomic nervous system and limbic system - endocrine signals -pituitary . AVP Vasopressin is synthsized in the hypothalamus and stored in brain and pituitary. Adrenocortocotropic hormone ACTH from adrenal cortex is secreted in response to cholecystokinin (CCK) which is responsible for the effects of anxiety. The 5HT3R-expressing neurons are mainly GABA-something cells. But what we know about GABA and magnesium is apparently correct to some degree . .. . > > > > > > Has anyone here tried Picamilon? It is an over-the-counter dietary supplement that contains GABA, which is an inhibitory neurotransmitter. There is some interesting research to suggest that a deficit in GABA plays a role in the sensory problems of people on the autism spectrum. > > > > > > I have no experience of this drug at all, but was just intrigued to see if anyone had ever used or tried it, even for other conditions. I have absolutely no idea whether it would help 4S and *I am not urging anyone to go out and try it*: I haven't read about its side-effects. Just wondering if anyone has heard of it. > > > > > > Some more info: > > > > > > https://secure.wikimedia.org/wikipedia/en/wiki/Picamilon > > > https://secure.wikimedia.org/wikipedia/en/wiki/Anxiolytic#Herbal_treatments > > > > > > Quote Link to comment Share on other sites More sharing options...
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