RE: UK Oncologists willing to think outside the box

[Guest guest]

,

Details of a recent UK study at Hammersmith using oestradiol patches are below. The Marsden were using patches when DES was scarce, but I don't know if they, or Hammersmith, are using them currently.

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J Urol. 2003 May;169(5):1735-7.

J Urol. 2003 May;169(5):1745-6. Transdermal estradiol therapy for advanced prostate cancer--forward to the past?Ockrim JL, Lalani EN, Laniado ME, SS, Abel PD.Department of Surgical Oncology, Faculty of Medicine, Imperial College, Hammersmith Hospitals NHS Trust, UK.PURPOSE: Current hormonal therapies for prostate cancer are associated with significant morbidities, including symptoms of andropause and osteoporosis. Oral estrogens prevented many of these problems but were abandoned due to cardiovascular toxicity attributed to hepatic effect. In contrast, parenteral estrogens prevent first pass hepatic metabolism and substantially reduce cardiovascular risk, and long-term transdermal estradiol therapy is believed to be cardioprotective. We report preliminary results of a pilot study using transdermal estradiol therapy to treat men with advanced prostate cancer. MATERIALS AND METHODS: A total of 20 patients with advanced prostate cancer were enrolled in a before and after study that examined the impact of estradiol patches on hormones, disease, thrombophilia, vascular flow, osteoporosis and quality of life. RESULTS: Median followup is 15 months. Estradiol levels greater than 1,000 pmol./l. were achieved using 2 patches and higher levels were obtained by increasing the number of patches. All patients achieved castrate levels of testosterone within 3 weeks and had biochemical evidence of disease regression. One patient died of disease at 14 months and 1 cardiovascular complication occurred. Thrombophilic activation was avoided and vascular flow improved. Bone mineral density was significantly increased. Mild or moderate gynecomastia occurred in 80% of patients but no patient had hot flushes. All other functional and symptomatic quality of life domains improved. CONCLUSIONS: Transdermal estradiol therapy produced an effective tumor response. Cardiovascular toxicity was substantially reduced compared with that expected of oral estrogen, and other morbidity (gynecomastia) was negligible. Transdermal estradiol therapy prevented andropause symptoms, improved quality of life scores and increased bone density. Transdermal estradiol costs a tenth of current therapy cost, with the potential for considerable economic savings over conventional hormone therapies.PMID: 12686820

UK Oncologists willing to think outside the box

I have been asked today for the name and place of work of a good UK oncologist willing to work with patients with the basic thinking of men like Myers. Do you know of any?

The other question is does anyone know if oestrogen patches are in use for PCa treatment anywhere?

[Guest guest]

Sammy,

If you need more information on the study, why not give one of the authors a call?

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UK Oncologists willing to think outside the box

I have been asked today for the name and place of work of a good UK oncologist willing to work with patients with the basic thinking of men like Myers. Do you know of any?

The other question

RE: UK Oncologists willing to think outside the box

,

Details of a recent UK study at Hammersmith using oestradiol patches are below. The Marsden were using patches when DES was scarce, but I don't know if they, or Hammersmith, are using them currently.

.

J Urol. 2003 May;169(5):1735-7.

J Urol. 2003 May;169(5):1745-6. Transdermal estradiol therapy for advanced prostate cancer--forward to the past?Ockrim JL, Lalani EN, Laniado ME, SS, Abel PD.Department of Surgical Oncology, Faculty of Medicine, Imperial College, Hammersmith Hospitals NHS Trust, UK. snip

[Guest guest]

Premoli is very approachable . If the person on whose behalf you asked the question would like to make contact with him via e-mail, do let me know off list.

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UK Oncologists willing to think outside theboxI have been asked today for the name and place of work of a good UKoncologist willing to work with patients with the basic thinking of men likeMyers. Do you know of any?The other question is does anyone know if oestrogen patches are in use forPCa treatment anywhere?

[Guest guest]

> Transdermal estradiol therapy produced an effective tumor response.

If you have read the paper what does that statement exactly mean? The abstract goes on a lot about other factors and despite one patient dying does not really go into the effect on PC. What blood markers were used, and what if any imaging was done before and after ?

Just wondering.

Sammy.

UK Oncologists willing to think outside the box

I have been asked today for the name and place of work of a good UK oncologist willing to work with patients with the basic thinking of men like Myers. Do you know of any?

The other question

UK Oncologists willing to think outside the box

I have been asked today for the name and place of work of a good UK oncologist willing to work with patients with the basic thinking of men like Myers. Do you know of any?

The other question is does anyone know if oestrogen patches are in use for PCa treatment anywhere?