Seizures Caused by Colonoscopy Premedication

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Seizures Caused by Colonoscopy Premedication

(Source: DocGuide) - Cornell University researcher's have found the

first reported case of generalized tonic-clonic seizures induced by

meperidine pre-medication for a colonoscopy procedure in a 63-year-old

woman with Alzheimer's disease. The active metabolite of meperidine,

normeperidine, is believe to be the cause of the seizures.

The brain changes which occur in Alzheimer's disease can themselves

also predispose to seizures.

The researchers recommend avoidance of meperidine for all flexible

endoscopic procedures on patients with Alzheimer's disease and in any

patient with a condition that predisposes to seizures, and suggest the

use of alternative opioids.

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