Re: Our story so far _ Very Long Sorry/Geodon/ Phosphatidylserine

[Guest guest]

, I have a different " tonic " to ask you about.

A lady is trying to get me to use Phosphatidylserine (PS for short)

to help Don. I don't do anything added to, or contrary to what his

Doctors Prescribe. I am afraid of bad results. After all his Doctor

said " less is more. " I don't want to add anything that could be in

conflict with what he is taking.

Can you tell me about Phosohatidylserine? The long name makes it

sound important, but as I understand, it is just a tonic of some sort.

I prefer staying with Doctors, and don't go along with all the

miracle cures that others rave about.

I would like to hear it from someone that knows more about

Pharmaceuticals than these people that try to push every cure under

the sun at me.

( As a side note, she and I have parted ways because of her pushing

me so hard to try this.)

Thanks . Your input is appreciated.

Imogene

IWard27663@...

>

> All atypical antipsychotics are required by the FDA to carry

a " black

> box " warning about their use in the demented elderly. There is a

> known association between atypical use and death/injury in the

elderly

> treated with atypical antipsychotics. This is a result of the CATIE

> trials, which you'll see me reference from time to time.

>

> Three points bother me here: first is that there's no evidence all

> the atypicals are the same, but they're treated the same by FDA in

the

> meantime. While there's agreement that all affect the D2 receptor

> type, some have more D4 activity than others, and some affect

> serotonin, catecholamine and histaminic receptors - thus they're

> *alike* as a class, but there's no requirement that they be

identical.

> My worry is that doctors see it like this:

>

> 1) Neuroleptic antipsychotics are bad for people with DLB/PDD.

>

> 2) Clozaril and Seroquel and Zyprexa and Risperdal have each been

> shown in some trials to be good for them.

>

> 3) New Drug that Chesty Blonde In A Low-Cut Top told me about is

also

> an atypical.

>

> 4) New Drug is good for people with DLB since it's in the same

class.

>

> 5) I have samples from the CBIAL-CT. Let's try it!

>

> Evidence-based medicine be damned.

>

> The second piece is that there's no evidence that conventional

> antipsychotics are safer - in fact, they're probably substantially

> more dangerous in the elderly, but because there's no negative

trials

> on a large scale like CATIE, these older drugs don't have to show

the

> Black Box warning, and there's evidence that their use is creeping

up,

> both from cost pressures with the atypicals (they're breathtakingly

> expensive) and from a perception that they may be safer (*eeep*).

>

> Third thing is that as a class, the evidence is emerging that the

side

> effect of sedation, seen in all antipsychotics that I'm aware of, is

> bad for people with DLB. Until we can change the perceptions of

> doctors in the community (many academics are already convinced) that

> sedating people with DLB to quiet them down is counterproductive,

> we're going to be fighting injury and death caused by excessive

sedation.

>

>

> E

>