thyroid symptom

[Guest guest]

i thought i wuold post this here as someone was talking about an old famous

thryoid sign of myxedema of Upper Arms and thighs

(Can't 'pinch " *just only the skin in those 2 places in those of us who had

Myxedema there! instead when you Try to pinch the skin,, you get about 1 inch

width or more due to the Myxedema

(When i first found the forums?

i literally could only pinch my entire Upper arm and could get NO " purchase " on

the top of my thighs was so ever

anyway;

i had this to a noticable degree on both upper arms and thighs. i guess my

doctors just thought i was in good shape muscle wise? :/ as they completely

ignored my " Signs " .

i saw Noticeable lessening literally overnight :/ about 6 weeks after Finally

being strong enough to switch to ALL_NTH (VS sinthroid+NTH combo) = but it has

come back a bit worse / over time / may be my less perfect " Adrenal Fatiuge "

lifesytle /including peri-Meno factors like sleep and crummier diet:

anyway:

i looked into this hypot symptom of skin myxedema /mucin

a while back and i think its an important clue of other things; things i wsih

our doctors were looking at or even knew about.

things like:

= there are different Types of Mucin and myxedema " ingredients " :/

wikigenes:

http://www.wikigenes.org/e/mesh/e/15151.html

"

Histochemical studies demonstrated that the material is different from the

__hyaluronic acid-rich substances__ of the *usual* forms of cutaneous mucinoses

[7].

"

"

The *infrequent* association of reticular erythematous mucinosis lesions and

other forms of cutaneous mucinoses with hypothyroidism is discussed, with

special emphasis on the fact that the underlying thyroid disease in all cases

was Hashimoto thyroiditis [17].

"

So yes, while INfrequent,, they were still all caused by HASHIS!!(VS the hypOT

part??)

=============================================

under GENE CONTEXT:

' "

This review discusses the primary mucinoses in which the predominant dermal

mucin is hyaluronic acid [19].

"

== hyaluronic acid appears to be a common cause of the famous HYPOT myxemotous

increase in sking /dermis / and our " Sign " of not being able to Pinch less than

an inch or 1/4 of an inch :0 whatever each person has..

and another link:

http://www.wikigenes.org/e/ref/e/2419372.html

=============================================

http://www.hyalogic.com/main/about_hyaluronic_acid

see

what is Hyalurnoic Acid?

and

What is Hyaluronic Acid's Chemical Structure?

It is naturally produced in the human body and is chemically classified as a

Glycosaminoglycan.

=============================================

http://en.wikipedia.org/wiki/Glycosaminoglycan

mucopolysaccharides aka GAGs are made by our Cells all over

" the exception is the GAG hyaluronan, which is uniquely synthesized without a

protein core and is " spun out " by enzymes at the cell surface directly into the

extracellular space.

"

HYALURONAN = The only GAG that is exclusively non-sulfated

read up on the above GAGs (old name for and you find LYSOSOME STORAGE inherited

diseases..

=============================================

but then see this:

http://www.ncbi.nlm.nih.gov/pubmed/7215332

A possible explanation of myxedema and hypercholesterolemia in hypothyroidism:

control of __ lysosomal hyaluronidase __ and cholesterol esterase by thyroid

hormones.

-Carol

the original links also included mention of these 2 items:

2)

**glucuronic acid :

http://en.wikipedia.org/wiki/Glucuronic_acid_

see: Glucuronidation of toxic substances

(including our HORMONES! and bile and etc)

3)

N acetyl glucosamine

http://en.wikipedia.org/wiki/N-Acetylglucosamine

N-Acetylglucosamine is a monosaccharide derivative of glucose.

"

Polymerized with glucuronic acid it forms hyaluronan.

"

Oh!

http://www.glyconutrient.biz/N-AcetylGlucosamine.htm

THIS CUOLD be the HASHIS? connection ??

"

N-acetylglucosamine receptors are found in the **thyroid gland,

which indicates that it plays a role in the transport of ***thyroglobulin** (an

iodine-containing ***glycoprotein).

Concentrated amounts of N-acetylglucosamine are found in the testes, liver,

small intestines, epithelial cells of the endocrine and sebaceous glands, and

**endothelial cells of blood_vessels, which indicates involvement in these

areas. Researchers are continuing to studies these areas to see precisely what

role N-acetylglucosamine plays in these areas.

"

but no Thyroid DRs are even looking at this area of science...

OR may be even the good Thryoid DRs don't have enough of a Biochemistry

background???

-Carol