great article on nih re; our real stress system -w / pics :)

[Guest guest]

The neuro-symphony of stress

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844123/

"

Each of these mediators acts on specific neuronal populations, resulting in

unique downstream effects. Together, these effects constitute the `stress

response', which enables the animal to adapt to the changing environment1-4.

A perplexing aspect of the stress response is its complexity.

Various stress mediators have been described, including neurotransmitters (for

example, noradrenaline and serotonin), peptides (for example,

corticotropin-releasing hormone (CRH), other members of the CRH family and

vasopressin) and steroid hormones (for example, cortisol in humans and

corticosterone in rodents). What is the reason for the existence of these

multiple instruments

"

some of their 'graphs' linked in the article itself

look at FIG 1

to see chemicals of our stress system that can get out of balance and cause our

amazing variety of " signs and sytmpoms "

and

TABLE 1 link

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844123/table/T1/

Examples of stress-activated neuropeptides in the brain

BOX 1 (Scroll down till you see the Circle graph

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844123/#BX1

Box 1. Temporal profiles of the orchestrated stress response

"

In summary, although each stress modulator contributes to the orchestrated

stress response through a main role with a defined temporal niche, it is now

clear that most modulators play additional, minor parts

"

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844123/figure/F4/

Figure 4

Direct interaction between different stress mediators

"

Finally, in view of the complexity of this stress neuro-symphony, it is not

surprising that many of its components can be deranged,

leading to stress-related disorders including depression and anxiety. An

improved understanding of how this system functions will enable better use of

current therapeutic interventions

"

(they forgot to including Adrenal Fatiuge :0

-Carol