Re: doctor visit

[Guest guest]

,

I thought that thyroid peroxidase was used in the thyroid as part of the process

of making thyroid hormones?

" Inorganic iodine enters the body primarily as iodide, I-. After entering the

thyroid follicle (or thyroid follicular cell) via a Na+/I- symporter (NIS) on

the basolateral side, iodide is shuttled across the apical membrane into the

colloid via pendrin, after which thyroid peroxidase oxidizes iodide to atomic

iodine (I) or iodinium (I+). The " organification of iodine, " the incorporation

of iodine into thyroglobulin for the production of thyroid hormone, is

nonspecific; that is, there is no TPO-bound intermediate, but iodination occurs

via reactive iodine species released from TPO.[3] The chemical reactions

catalyzed by thyroid peroxidase occur on the outer apical membrane surface and

are mediated by hydrogen peroxide. "

http://en.wikipedia.org/wiki/Thyroid_peroxidase

It is the deiodinases (D1, D2 and D3) that are involved in converting T4 to T3

(and various other processes). (And yes, it can be confusing that

" Three types of iodothyronine deiodinases (D1, D2, D3) have been identified in

vertebrates which differ in tissue distribution, substrate specificity and

sensitivity to inhibiting compounds (83). D1 and D2 catalyze primarily the

removal of one iodide from the outer tyrosine ring of T4 to produce T3. D3

catalyzes the cleaving of one iodide from the inner tyrosine rings of T4 and T3

generating inactive iodothyronine derivatives (e.g. reverse T3 and

diiodothyronines), respectively. "

http://www.thyroidmanager.org/Chapter1/1-frame.htm

Also, Figure 1 in this paper is a nice diagram of what D1, D2 and D3 can do.

http://www.jci.org/articles/view/29812

If by some chance I am right, you might care to find an integrative doctor who

integrates real understanding.

Rod

>

> Hi,

>

> I was able to go to an integrative doctor yesterday with my results from

> ZRT labs. He changed me to Cytomel, T3 only, from Synthroid which is T4

> only. Since I had a high level of TPO anti-bodies, and TPO changes T4

> (your reservoir) to T3 (what you actually use in cells), he said that my

> body cannot convert the T4 to T3 so it can be used. Therefor the

> synthroid was useless. No wonder I felt like I was dragging a 2 ton

> elephant behind me all day long!!! He treats to how you feel, not

> specific levels, so I will use the T3 and slowly can up it until I feel

> " well " and not hyperthyroid.

>

> After doing this, he will work on my low progesterone....

>

> As for the antibodies to TPO, which is a marker for hashis, he said that

> they can go down as I will not have T4 needing conversion. He suspects

> some leaky gut issues that may have caused them...

>

> Hoping to feel better soon!!!

>