(article) Epigenetic transgenerational inheritance of altered stress responses

[Guest guest]

I read this article today and found it very distressing. Have you read

this one, Bill?

Epigenetic transgenerational inheritance of altered stress responses

http://www.pnas.org/content/early/2012/05/15/1118514109.full.pdf+html?sid=60d570\

0b-bb9c-4fcc-b825-f6f34c557c3e

Enjoy (or not),

~CJ

[Guest guest]

CJ wrote:

>

> I read this article today and found it very distressing. Have you read

> this one, Bill?

I hadn't. But now I have. What it is that distresses you?

The whole thing has a little bit Lamarckian flavor I guess - to a layperson.

But " epigenetics " is a well-established phenomenon, and our brain is

our most " plastic " organ throughout our lives.

Many NON-behavioral " genetic " traits are affected that way. Why should

the brain - and behavior - be exempt?

This paper's importance, such as it may be, lies in showing a

*behavioral* trait being epigenetically affected across generations.

That is, yet another type of *non-DNA* change is inheritable.

A couple of things to note:

1. They admit not *directly* measuring epigenetic effects.

2. The paper was taken on via " direct submission " . National Academy

full members can publish in PNAS *without* normal peer review. I don't

know if that was the case here.

So I'd like to see corroborative evidence. Given the complexity of the

experiments and observations, I'd not expect to see such anytime soon. <g>

>

> Epigenetic transgenerational inheritance of altered stress responses

>

>

http://www.pnas.org/content/early/2012/05/15/1118514109.full.pdf+html?sid=60d570\

0b-bb9c-4fcc-b825-f6f34c557c3e

>

- Bill, ...AS, ...retired clinical/research geneticist

--

WD " Bill " Loughman - Berkeley, California USA

http://home.earthlink.net/~wdloughman/wdl.htm

[Guest guest]

Bill said it before I did. N. Meyer Re: (article) Epigenetic transgenerational inheritance of altered stress responses > >CJ wrote: >> >> I read this article today and found it very distressing. Have you read >> this one, Bill? > >I hadn't. But now I have. What it is that distresses you? > >The whole thing has a little bit Lamarckian flavor I guess - to a layperson. > But "epigenetics" is a well-established phenomenon, and our brain is >our most "plastic" organ throughout our lives. > >Many NON-behavioral "genetic" traits are affected that way. Why should >the brain - and behavior - be exempt? > >This paper's importance, such as it may be, lies in showing a >*behavioral* trait being epigenetically affected across generations. >That is, yet another type of *non-DNA* change is inheritable. > >A couple of things to note: > >1. They admit not *directly* measuring epigenetic effects. >2. The paper was taken on via "direct submission". National Academy >full members can publish in PNAS *without* normal peer review. I don't >know if that was the case here. > >So I'd like to see corroborative evidence. Given the complexity of the >experiments and observations, I'd not expect to see such anytime soon. > >> >> Epigenetic transgenerational inheritance of altered stress responses >> >> http://www.pnas.org/content/early/2012/05/15/1118514109.full.pdf html?sid=60d5700b-bb9c-4fcc-b825-f6f34c557c3e >> > >- Bill, ...AS, ...retired clinical/research geneticist > >-- >WD "Bill" Loughman - Berkeley, California USA >http://home.earthlink.net/~wdloughman/wdl.htm