Plasma 25-Hydroxyvitamin D Levels and Risk of Incident Hypertension

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Inverse Association between Plasma 25-Hydroxyvitamin D Levels and Risk

of Hypertension

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Plasma 25-Hydroxyvitamin D Levels and Risk of Incident

Hypertension, " Forman JP, Giovannucci E, et al, Hypertension, 2007 Mar

19; [Epub ahead of print]. (Address: Channing Laboratory, Department of

Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston,

MA, USA. E-Mail: jforman@... ).

Summary: In a study involving 613 men and 1,198 women with measured

plasma 25(OH)D levels prospectively followed for 4-8 years, and 38,388

men and 77,531 women with predicted 25(OH)D levels prospectively

followed for 16-18 years, an inverse association was observed between

plasma 25(OH)D (25-hydroxyvitamin D) levels and risk of hypertension. In

the cohorts with measured plasma levels of 25(OH)D, men with plasma

25(OH)D levels less than 15 ng/mL (vitamin D deficiency) showed more

than a six-fold increased risk of hypertension compared to men with

25(OH)D levels at or above 30 ng/mL. Similarly, women with vitamin D

deficiency showed more than a two-fold increased risk of hypertension

compared to women with 25(OH)D levels at or above 30 ng/mL. Furthermore,

in a pooled analysis combining men and women, vitamin D deficiency was

associated with more than a three-fold increased risk of hypertension.

Additionally, in the cohorts with predicted 25(OH)D levels, men in the

lowest decile of 2 5(OH)D levels showed more than a two-fold increased

risk of hypertension compared to men in the highest decile. Similarly,

women in the lowest decile of 25(OH)D levels showed a 57% increased risk

of hypertension compared to women in the highest decile. Thus, the

authors of this study conclude, " Plasma 25(OH)D levels are inversely

associated with risk of incident hypertension. "

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