Serum Vitamin D...May Be Inversely Associated with Disease Activity in Pts with Early Inflammatory Polyarthritis

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Serum Vitamin D Metabolite Levels May Be Inversely Associated with

Current Disease Activity in Patients with Early Inflammatory Polyarthritis

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Association between serum vitamin D metabolite levels and

disease activity in patients with early inflammatory polyarthritis, "

Patel S, Farragher T, et al, Arthritis Rheum, 2007; 56(7): 2143-2149.

(Address: St. Helier University Hospital, Carshalton, London, UK.

E-mail: sanjeev.patel@... ).

Summary: In a study involving 206 consecutive patients with early

inflammatory polyarthritis (IP), an inverse association was observed

between serum vitamin D metabolite levels and disease activity. The

patients - none of whom were taking any steroids, and all of whom

received less than 6 weeks of disease-modifying therapy - were studied

within 6 months of symptom onset. At baseline, inverse associations were

observed between 25(OH)D levels and tender joint count, Disease Activity

Score 28-joint assessment (DAS-28) scores, and Health Assessment

Questionnaire (HAQ) scores. Additionally, an inverse association was

observed between 1,25(OH)(2)D and HAQ scores. At 1 year, only the

inverse association between baseline vitamin D metabolite levels and HAQ

score remained significant. Thus, the authors of this study conclude,

" These data provide further support that vitamin D plays an

immunomodulatory role in inflammatory arthritis. This association needs

to be examined in other cohorts o f patients with early IP, as well as

in longitudinal studies. If confirmed, the clinical response to vitamin

D supplementation should be examined in early IP. "

--

ne Holden, MS, RD < fivestar@... >

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