Allergy Advisor-Digest (Great summary of allergy news)

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CONTENTS:

1. A selection of allergy & intolerance articles and data added to

Allergy Advisor last month

2. View the contents of recent Allergy and Dietetics journals -

http://allallergy.net/abstracts/journalContentsList.cfm

3. Allergy Advisor Information

Part of the Allergy Resources International family:

* Allergy Advisor

* Allergy Advisor Digest

* Allergy Advisor Educational Review

* Allergy Advisor Food Matters

* AllAllergy.net

____________________________________

1. SELECTION OF ALLERGY & INTOLERANCE ARTICLES

This newsletter only highlights some of the more interesting articles being

added to Allergy Advisor. More articles and abstracts can be viewed at

Allergen Advisor Digest - http://allallergy.net/abstracts/index.cfm

An occupational respiratory allergy caused by White mustard (Sinapis alba)

pollen in olive farmers.

White mustard (Sinapis alba) is a entomophilic species of the Brassicaceae

family. In this study, 12 olive orchard workers had a history of rhinitis

and/or bronchial asthma that occurred during control weed management and/or

harvest, from January to March. Eleven patients suffered from rhinitis and

bronchial asthma and one had only from rhinitis. All patients were sensitized

to S.

alba pollen extract, and they showed a positive NCT response. Aerobiologic

monitoring showed that the amount of S. alba pollen only exceptionally reached

peaks of 21 grains/m(3), whereas in the work environment peaks of 1801

grains/m(3) were detected between February and April. The study concludes that

S.

alba pollen is a new occupational allergen for olive farmers.

Anguita JL, Palacios L, Ruiz-Valenzuela L, Bartolome B, -Urbano MJ,

Saenz de San PB, Cano E, Quiralte J.

An occupational respiratory allergy caused by Sinapis alba pollen in olive

farmers.

Allergy 2007 Apr;62(4):447-450

____________________________________

Two different profiles of peach allergy in the north of Spain.

Peach allergy has two different patterns: central Europe with oral allergy

syndrome (OAS) related to a primary sensitization to birch pollen Bet v 1 and

profilins and southern Europe with mostly systemic symptoms, in many cases

due to sensitization to lipid-transfer proteins. In this study, 30

peach-allergic patients with positive skin and food challenge tests and 29

control

subjects were studied. Pru p 3 was the major allergen in the patient group from

northern Spain. Sensitization to this allergen was found in 100% of the

patients

with systemic symptoms or contact urticaria. Only 60% of OAS patients were

sensitized to Pru p 3, being all of them sensitized to profilins and 60% of

them to allergens of the Bet v 1 family. Specific IgE determination and BAT

using recombinant allergens (rPru p 3) show specificity and sensitivity values

close to 100%. Thus, in the north of Spain the patients showed a mixed

central-south Europe pattern with LTP-profilin-Bet v 1 sensitization depending

on

the symptoms presented. T he use of natural and recombinant plant allergens,

allows establishing the sensitization patterns to the different allergens

studied.

Gamboa PM, Caceres O, Antepara I, -Monge R, Ahrazem O, Salcedo G,

Barber D, Lombardero M, Sanz ML.

Two different profiles of peach allergy in the north of Spain.

Allergy 2007 Apr;62(4):408-414

____________________________________

Anaphylaxis to lemon soap: citrus seed and peanut allergen cross-reactivity.

A report of a peanut allergic patient who exhibited cosensitivity to citrus

seeds and who had experienced anaphylaxis to lemon soap. Extracts of peanut

and seeds from different varieties of citrus fruit (orange, lemon, and

mandarin) were prepared and numerous IgE reactive proteins were demonstrated in

each

citrus seed extract and the peanut extract. Complete IgE cross-reactivity

was demonstrated among the different citrus seed extracts. Partial

cross-reactivity was demonstrated between the peanut and orange seed extracts.

The study

concludes that citrus seeds contain numerous IgE reactive proteins that are

completely cross-reactive among orange, lemon, and mandarin. When peanut

allergy coexists with citrus seed allergy, IgE cross-reactivity between peanut

and citrus seed proteins can be demonstrated, suggesting a basis to this

cosensitivity.

Glaspole IN, de Leon MP, Rolland JM, O'Hehir RE.

Anaphylaxis to lemon soap: citrus seed and peanut allergen cross-reactivity.

Ann Allergy Asthma Immunol 2007 Mar;98(3):286-289

____________________________________

Rice, black gram, lentil and citrus fruit sensitisation in asthmatics.

In this study, the relevance of serum total and specific IgE was

investigated in asthmatics with food sensitization. Out of 216 consecutive

patients, 172

were with elevated serum total IgE (201 to > 800 IU/ml). Rice elicited

marked positive skinprick test reactions (SPT) in 24 (11%) asthma patients

followed by black gram 22 (10%), lentil 21 (9.7%) and citrus fruits 20 (9.2%).

Serum

total IgE and specific IgE showed significant correlation with positive skin

tests. Blinded food challenges (DBPCFC) with rice and or black gram

confirmed food sensitization in 28-37% of cases. In summary, serum total IgE of

265

IU/ml or more with marked positive SPT (4 mm or more) can serve as marker for

atopy and food sensitization. Specific IgE, three times of normal controls

correlates well with positive DBPCFC and offers evidence for the cases of food

allergy.

Kumar R, Singh BP, Srivastava P, Sridhara S, Arora N, Gaur SN.

Relevance of serum IgE estimation in allergic bronchial asthma with special

reference to food allergy.

Asian Pac J Allergy Immunol 2006 Dec;24(4):191-199

____________________________________

Lime dermatitis from gin and tonic with a twist of lime.

Lime dermatitis from gin and tonic with a twist of lime. A 52-year-old woman

presented with an eczematous rash at the side of her mouth and lips. She had

been sucking the limes in her gin and tonic for up to 1 min after finishing

her drink. Patch tests were positive for geraniol 2%, geranium oil and lime

peel. Citrus oil is made up of 90% limonene and the remaining 10% consists of

citral, gerraniol and bergapten.

Thomson MA, Preston PW, Prais L, Foulds IS.

Lime dermatitis from gin and tonic with a twist of lime.

Contact Dermatitis 2007 Feb;56(2):114-115

____________________________________

Occupational contact urticaria from Parmesan cheese.

Occupational contact urticaria from Parmesan cheese in a 35-year-old sanwich

shop worker. She presented with a 6-month history of vesicular dermatitis

affecting the sides of her fingers, fingertips and right hand, spreading to her

forearms, wrists, elbows and right leg. Patch tests and SPT tests were

performed. Skinprick test was positive to her own parmesan cheese. The specific

ingredient was not identified.

JD, Moyle M, Nixon RL.

Occupational contact urticaria from Parmesan cheese.

Contact Dermatitis 2007 Feb;56(2):113-114

____________________________________

Pollen from cannabis in the atmosphere of za, Northen Italy.

This study found, in addition to well-known aeroallergens, a significant

percentage of pollen from Cannabaceae from the end of July to mid September.

The

potential allergenicity of Cannabis pollen is supported by a study from the

United States, where it was found that some patients with rhinitis or asthma

during the pollen seasons and positive skinprick test for Cannabis, but the

clinical significance of Cannabaceae pollen as an aeroallergen in Europe is

still undefined.

Torre FD, Limonta A, Molinari A, Masala E, Vercelloni S, Torre ED.

Cannabaceae pollen in the atmosphere of za, Northen Italy.

Allerg Immunol (Paris) 2007 Jan;39(1):9-11

____________________________________

Clinical characteristics of soybean allergy in Europe.

This study sought to determine the clinical characteristics of soy allergy

in Europe, including a dose-response curve. Patients with a history of soy

allergy underwent a titrated, double-blind, placebo-controlled food challenge.

A

statistical model was used to calculate the risk of allergic consumers to

experience an allergic reaction to soy. Sera were analyzed for specific IgE to

soy, peanut, Bet v 1, and Gly m 4. All patients but one responded primarily w

ith subjective symptoms to the challenge followed by objective symptoms in 11

subjects, ranging from rhinitis up to a decrease in blood pressure.

Cumulative threshold doses for allergic reactions ranged from 10 mg to 50 g for

subjective symptoms and from 454 mg to 50 g for objective symptoms. The pattern

of IgE reactivity against proteins with molecular weights of between

approximately 10 and 70 kd was highly individual among the patients and did not

correlate with the severity of symptoms. The study concludes that when data are

fitted by using a normal di stribution statistical model, they predict that 1%

of patients with soy allergy would react subjectively and objectively with

0.21 and 37.2 mg of soy protein, respectively, and that both the clinical and

immunologic basis of soy allergy in Europe are highly complex, which affects

the diagnosis of soy allergy and the advice given to patients with soy allergy

in regard to risk management.

Ballmer-Weber BK, Holzhauser T, Scibilia J, Mittag D, Zisa G, Ortolani C,

Oesterballe M, Poulsen LK, Vieths S, Bindslev-Jensen C.

Clinical characteristics of soybean allergy in Europe: A double-blind,

placebo-controlled food challenge study.

J Allergy Clin Immunol 2007 Mar 20;

____________________________________

Occupational sensitization to lupin in the workplace.

This study was a cross-sectional study of workers in a food processing

company who were exposed to lupin and developed occupational allergy secondary

to

inhaling lupin products. A total of 53/54 subjects completed testing (98%).

Overall, 21% (11/53) had positive SPT results to lupin. Seven of 11 (64%)

subjects in this group were symptomatic; all had rhinitis, and 2 had wheeze.

Two

subjects had positive methacholine challenges, and 1 had a positive specific

bronchial provocation challenge to lupin with both an early-phase and a

late-phase response.

CP, AS, AR, PS, Yates DH.

Occupational sensitization to lupin in the workplace: Occupational asthma,

rhinitis, and work-aggravated asthma.

J Allergy Clin Immunol 2007 Mar 20;

____________________________________

Cat IgA, representative of new carbohydrate cross-reactive allergens.

Four cat allergens have been identified; however, evidence indicates the

existence of additional allergens. In this study, IgE sensitization to IgA from

cat was evaluated. Sera from cat-sensitized patients (n = 81) were analyzed

for IgE antibodies to purified cat IgA in the Pharmacia CAP System.

Thirty-eight percent (31/81) of the cat-sensitized sera were ImmunoCAP-positive

to cat

IgA. Indirect ELISA demonstrated a high correlation between IgE reactivity to

cat IgA and cat IgM. Very low responses were observed to deglycosylated IgA.

Immunoblotting demonstrated that the IgE reactivity was mainly directed to

the heavy chain of IgA. This study has revealed a new allergen, cat IgA,

containing a novel group of cross-reactive epitopes depending on carbohydrates

also present on IgM and partially on CIP.

Adedoyin J, Gronlund H, Oman H, Johansson SG, van HM.

Cat IgA, representative of new carbohydrate cross-reactive allergens.

J Allergy Clin Immunol 2007 Mar;119(3):640-645

____________________________________

Other interesting articles featured this month can be viewed at

http://allallergy.net/abstracts/index.cfm and include:

Urticaria due to calcium pidolate.

Turnip and zucchini: new foods in the latex-fruit syndrome.

Myrmecia pilosula (Jack Jumper) ant venom: identification of allergens and

revised nomenclature.

Magnesium sulfate-induced nonallergic anaphylaxis.

Rhinoconjunctivitis and asthma caused by corn plant (Dracaena fragrans).

Allergenicity of the Madagascar hissing cockroach.

Allergen activity of xerophilic fungi, Aspergillus restrictus.

Allergic contact dermatitis to hydrolyzed wheat protein in a cosmetic cream.

Contact urticaria to olives.

Allergic contact dermatitis from Arum lily (Lily of the Nile)

Predictors of work-related symptoms, allergic sensitisation and occupational

asthma among supermarket bakery workers.

The characterisation and generation of natural and recombinant parvalbumin,

the major cross-reactive allergen in fish.

A case of breastfeeding anaphylaxis.

Oral desensitization in children with milk and egg allergies obtains

recovery in a significant proportion of cases. A randomized study in 60

children

with cow's milk allergy and 90 children with egg allergy.

Recurrent Anaphylaxis due to Non-Ruptured Hepatic Hydatid Cysts.

Perceived Food Allergy in Children in 10 European Nations.

Analysis of the Relationship between Pollinosis and Date of Birth in

Switzerland.

Cloning, sequencing, and recombinant production of Sin a 2, an allergenic

11S globulin from yellow mustard seeds.

Sesame food allergy and sensitization in children: the natural history and

long-term follow-up.

Contact dermatitis to a canine anti-dandruff shampoo.

____________________________________

2. MONTHLY CONTENTS LIST OF ALLERGY & DIETETIC JOURNALS

View the monthly listing of journal contents of all the major allergy and

intolerance-related journals in print or online at Allergy Advisor Journal

Contents. A number of new journals have been added.

The Allergy Advisor Web site is at http://AllergyAdvisor.com/ and the links

to this great feature is accessible through the menu bar below along the top

of the site. A " Search " facility has been added.

Contents List of Allergy & Dietetic Journals by Journal:

_http://allallergy.net/abstracts/journalContents.cfm_

(http://allallergy.net/abstracts/journalContents.cfm)

Contents List of Allergy & Dietetic Journals by Month:

_http://allallergy.net/abstracts/journalContentsMonth.cfm_

(http://allallergy.net/abstracts/journalContentsMonth.cfm)

List of ALL Allergy Articles This Month:

_http://allallergy.net/abstracts/journalContentsList.cfm_

(http://allallergy.net/abstracts/journalContentsList.cfm)

____________________________________

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