[The significance of diet and associated factors in psoriasis.]

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Hautarzt. 2006 Jun 7; [Epub ahead of print]

[The significance of diet and associated factors in psoriasis.]

[Article in German]

Wolters M.

Abteilung Ernahrungsphysiologie und Humanernahrung, Institut fur

Lebensmittelwissenschaft, Zentrum Angewandte Chemie, Universitat

Hannover, Wunstorfer Strasse 14, 30453 , Hannover,

maike.wolters@....

Psoriasis is a T cell mediated inflammatory skin disease

characterized by hyperproliferation and reduced differentiation of

epidermal keratinocytes. In severe cases, the disease can result in an

insufficient nutritional status which may even be promoted by

nutrient-drug interactions. Both the general diet and single food

components have been suggested to play a role in etiology and

pathogenesis of psoriasis. Fasting periods, vegetarian diets, and diets

rich in omega-3 polyunsaturated fatty acids from fish oil have all been

associated with improvement in some studies. The most likely explanation

is the reduced amounts of arachidonic acid and the increased

eicosapentaenoic acid intake resulting in a modulated eicosanoid

profile. However, only one of four controlled studies showed a benefit

of omega-3 fatty acids compared to placebo. Some psoriasis patients are

gluten-sensitive and may benefit from a gluten free diet. The active

form of vitamin D exhibits anti-proliferative and immunoregulatory

effects and has been shown to be useful in the treatment of psoriasis.

PMID: 16758223 [PubMed - as supplied by publisher]

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