... long-term use of anti-inflammatory medication can cause osteoporosis

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Public release date: 27-Jul-2006

http://www.eurekalert.org/pub_releases/2006-07/joci-rrh072006.php

Contact: Grindlinger

press_releases@...

Journal of Clinical Investigation

Researchers reveal how long-term use of anti-inflammatory medication can

cause osteoporosis

The steroid hormones glucocorticoids (GCs) are used at high doses to

treat inflammatory and immune disorders, however they prompt bone loss

and can cause osteoporosis, particularly when administered for prolonged

periods. In a study appearing online on July 27 in advance of print

publication in the August issue of the Journal of Clinical

Investigation, Teitelbaum and colleagues from Washington

University School of Medicine investigated how GCs alter the activity of

the bone-forming and bone-degrading cells known as osteoblasts and

osteoclasts, respectively.

The authors compared the effects of the GC dexamethasone (commonly used

to treat rheumatoid arthritis) on bone-degrading osteoclasts and their

precursors cells from healthy mice, with its effects on the same cells

derived from mice with disruption of the GC receptor. In healthy mice

they found that while the steroid prolonged the longevity of

osteoclasts, their bone-degrading capacity was suppressed. In mice

lacking the GC receptor, no such effects were observed. It was

previously known that bone degradation by osteoclasts stimulated new

bone formation by osteoblasts. The results of the current study indicate

that it is the GC-induced delay in the death of osteoclasts that dampens

osteoblast activity and as such retards new bone formation, resulting in

GC-induced osteoporosis.

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TITLE: Glucocorticoids suppress bone formation via the osteoclast

AUTHOR CONTACT:

L. Teitelbaum

Washington University School of Medicine, St. Louis, Missouri, USA.

Phone:

Fax:

E-mail: teitelbs@....

View the PDF of this article at:

https://www.the-jci.org/article.php?id=28084

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