Alpha-Lipoic Acid Improves Insulin Sensitivity in Patients with Type 2 Diabetes Mellitus

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Alpha-Lipoic Acid Improves Insulin Sensitivity in Patients with Type 2

Diabetes Mellitus

Reference: " Improvement of insulin sensitivity in patients with type 2

diabetes mellitus after oral administration of alpha-lipoic acid, "

Kamenova P, Hormones (Athens), 2006; 5(4): 251-8. (Address: Department

of Diabetology, University Hospital of Endocrinology, Medical

University, Sofia, Bulgaria. E-mail: kamenovap@... ).

Summary: In a study involving 12 patients with type 2 diabetes (mean

age: 52 years, mean BMI: 33.9), oral supplementation with alpha-lipoic

acid (ALA) was found to significantly improve peripheral insulin

sensitivity among diabetic patients. Subjects were treated with 600 mg

of ALA, twice a day, for a period of 4 weeks. By the end of the 4 weeks,

insulin sensitivity was found to have significantly increased from 3.202

to 5.951 mg/kg/min. Insulin sensitivity index also increased

significantly from 4.706 to 7.673 mg/kg/min per mIU/l x 100. After 4

weeks of treatment with ALA, the insulin sensitivity of diabetics was

not statistically different from the insulin sensitivity of controls

with normal glucose tolerance. These results suggest that " short-term

alpha-lipoic acid treatment increases peripheral insulin sensitivity in

patients with type 2 diabetes mellitus. "

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