DHA Deficiency in Postmortem...Cortex of Patients with Major Depressive Disorder

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DHA Deficiency in Postmortem Orbitofrontal Cortex of Patients with

Major Depressive Disorder

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Reference: " Selective Deficits in the Omega-3 Fatty Acid

Docosahexaenoic Acid in the Postmortem Orbitofrontal Cortex of Patients

with Major Depressive Disorder, " McNamara RK, Hahn CG, et al, Biol

Psychiatry. 2006 Dec 21; [Epub ahead of print]. (Address: Department of

Psychiatry, University of Cincinnati College of Medicine, Cincinnati,

Ohio, USA).

Summary: In a study involving 15 patients with DSM-IV-defined major

depressive disorder (MDD) and 27 age-matched controls, a selective

deficit in the omega-3 fatty acid docosahexaenoic acid (DHA) was

observed in the postmortem orbitofrontal cortex of the patients. After

correcting for multiple comparisons, DHA levels in the postmortem

orbitofrontal cortex of MDD patients was found to be 22% lower than that

in normal controls. Additionally, DHA levels in the postmortem

orbitofrontal cortex of MDD patients were found to be 32% lower among

female patients and 16% lower among male patients, compared to controls.

The deficits in DHA could not be entirely attributed to lifestyle

factors or postmortem tissue variables. Thus, the authors of this study

conclude, " These results demonstrate a selective deficit in the omega-3

fatty acid DHA in the orbitofrontal cortex of patients with MDD. "

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