Augmenting Zinc Suppl. with Vit.A, D May Increase Plasma Concentrations of Zinc: Implications for Alzheimer 's Disease and Other Diseases

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Augmenting Zinc Supplementation with Vitamins A and D May Increase

Plasma Concentrations of Zinc: Implications for Alzheimer 's Disease and

Other Diseases

http://www.vitasearch.com/CP/weeklyupdates/

Reference: " Oral zinc augmentation with vitamins A and D increases

plasma zinc concentration: Implications for burden of disease, " Potocnik

FCV, vanRensburg SJ, et al, Metabolic Brain Disease, 2006; 21(2-3):

139-147. (Address: Potocnik FCV, Private Bag X 13, ZA-7535 Bellville,

South Africa).

Summary: In this study, the effects of augmenting zinc supplementation

with various combinations of vitamins A and D on plasma zinc levels were

investigated. The authors cite a previous study in which patients with

Alzheimer's disease were supplemented with zinc, and while benefits were

found in terms of cognitive and physiological functions, plasma zinc

levels were inconsistent. So in this study, the authors report a case

study in which a patient supplementing with 15 mg/d zinc was given, in

addition to zinc, various combinations of vitamins (in RDA

concentrations) to assess their effects on plasma zinc levels. Vitamins

A and D were found to have the most beneficial effects. A follow-up

study was conducted involving 70 patients, who were given one of seven

combinations of zinc, vitamin A, and vitamin D. Levels of zinc in plasma

were measured at baseline, 3 weeks, and 6 weeks. Results found that the

combination of zinc plus vitamins A and D led to significant increases

in plasma zinc concentrations (from 11.82 to 13.32 mu m/L), while the

other combinations - a) zinc alone; vitamin A alone; c) vitamin D

alone; d) zinc plus vitamin A; e) zinc plus vitamin D; f) vitamins A and

D - produced no significant, consistent increase in plasma zinc

concentrations. The authors conclude, " This novel method of increasing

plasma zinc levels by the augmentation of vitamins A and D may have

implications for the reduction of burden of disease. "

--

ne Holden, MS, RD < fivestar@... >

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