Re: hydroxyproline (was Re: microsilica & other binders questions)

[Guest guest]

Thank you, Zeph.

My son is on chitosan on and off for binding up biotoxins in the

bloodstream. I think I fail to understand how chitosan can help with low

hydroxyproline or enhancing onnective tissues. Please kindly elaborate for

me. Thank you.

If there is a deficiency or deficits in prolyl hydroxylase (or

procollagen-proline dioxygenase), the conversation of proline to

hydroxyproline might be affected. Zinc actually inhibits prolyl hydroxylase

activity. I reviewed my son's old urine amino acid test results. His

proline levels were also fine in year 2005 and 2006. Urinary hydroxyproline

was actually elevated in 2005 and normalized in 2006. I wonder if his

recent test results of undetectable urine and plasma hydroxyproline result

from supplementation of high zinc.

Limin

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Sent: Friday, March 19, 2010 07:49 AM

To: <BorreliaMultipleInfectionsAndAutism >

Subject: hydroxyproline (was Re:

microsilica & other binders questions)

> Limin,

> Sorry, for late response - I'm not on the list daily.

>

> I WIKIed Hydroxyproline and looked at some links about 2 layers out. Then

> I went back over our health histories - including out Yasko testing. He is

> a bit flexable but does not have your CBS drain mutation. I was looking

> for similarities in the science and our testing to find any helpers.

>

> Supplementing gelatine gives only a small amount to the body. Most is

> eaten up in stomach acid.

> Vitamin C

> Lysine

> Jello (gelatine packets)

> Meat gelatine (broth)

> Hydroxy B12

> Niacinamide

> NADH

> Chitosan

> Silica

> HBOT (Hydroxylation is an oxidative process)

> Anything that is good oil for the cell wall / lipids

> And most supplements that address Liver / Anxiety / Kidney / Adrenal

>

> Also, I remember Owens mentioning oxalates forming down the chain

> from Hydroxyproline. The oxalate free diet made my son very weak within a

> few days. Going off Vit C was not good. He takes a minimum of 2000mg a

> day.

>

> My son says these foods give him energy and he prefers them above all

> else.: Rice, beef, peas (and the pea protein flour), jello.

>

> When I looked at connective tissues, I found epithelial, muscle, and

> nervous tissue) mentioned. So, this may have vast implications to the gut

> muscle/ muscle / nerve connection to brain collagen. Specific for us is

> the endoplasmic reticulum arena of the Lumen. The Wiki page contains

> waaaay too many suggestive words that are connected to our testing for it

> to be ignored: phospholipid membrane, protein disulfide, sarcosine,

> glycosyltransferase, cytochrome P450...

>

> The websites I saw:

> http://en.wikipedia.org/wiki/Hydroxyproline

> http://en.wikipedia.org/wiki/Hydroxylation

> (helps bond in Transglutaminases

> http://en.wikipedia.org/wiki/Transglutamination

> http://en.wikipedia.org/wiki/Lumen_(anatomy)

> http://en.wikipedia.org/wiki/Connective_tissue

> http://en.wikipedia.org/wiki/Endoplasmic_reticulum

>

> I believe that's about as far as I can speculate. I'm no rocket scientist.

> But, I have a Question that has gone unanswered for a while: What would

> impair hydroxylation?

>

> Hope any or all was helpful,

> ~zeph

>

>

>

>>

>> Zeph,

>>

>> I just got back my son's urine and plasma amino acids tests. Guess what?

>> My son has no hydroxyproline detected in urine and plasma. What do I

>> need

>> to do to increase his hydroxyproline levels? Vitamin C and silica? In

>> fact, he had been on so much silica (BioSil and MicroSilica) that Zyto

>> started picking up silica as stressor. I think that silica might not be

>> our

>> answer. He wastes glycine. Urine glycine is twice as much as the

>> reference

>> range. Plasma glycine is at the low end of the reference range.

>> Supplementing glycine might not be it. How do I help his body to

>> maintain a

>> good glycine level? His proline levels seem to be fine. So the

>> conversion

>> from proline to hydroxyproline might not be working right.

>>

>> His ligaments seem to be loosely connected and is super flexible

>> physically.

>> He can easily do a side to side leg split larger than 180 degree -

>> sometimes

>> it is scary to see. I can almost imagine that the tissues of his

>> internal

>> organs are also loosely bound together at the molecular level, because

>> the

>> weakness on the special amino acid sequence that is supposed to make

>> tight

>> collagen triple helix particularly stable.

>>

>> Limin

>>

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