Suppressed NKC activity in patients with breast implants

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Just thought I would post this!

Patty

Toxicol Ind Health 1994 May-Jun;10(3):149-54

>

>

> Suppressed natural killer cell activity in patients with silicone

breast

> implants: reversal upon explantation.

>

> A, Brautbar N, Vojdani A

>

> Center for Immune, Environmental & Toxic Disorders, Health Science

Center,

> Houston, Texas.

>

> We have previously shown that natural killer (NK) cell activity is

> significantly suppressed in patients with silicone breast

implants. These

> patients were symptomatic and the suppression of natural killer

cell

> activity was associated with additional significant immunological

> abnormalities (Vojdani et al., 1992a). Our studies have recently

been

> confirmed by et al. (1994), who described natural killer cell

activity

> suppression following exposure to silicone gel, and reversal upon

removal

of

> the gel. This study has been designed to evaluate natural killer

cell

> activities in symptomatic women with silicone breast implants and

again

> after explantation of the implants. Each patient served as her own

control.

> Our findings show a marked significant increase in previously

suppressed

> natural killer cell activity in 50% of the patients. In the other

50%, no

> change or suppressed NK activity was observed. These findings are

compatible

> with recent studies in experimental animals, which show that

administration

> of silicone reduces natural killer cell activity, and that this is

> reversible upon removal of the silicone. Since NK cells are

important in

the

> control of tumor cell growth, we propose here that patients with

reduced

NK

> cell activity are at a higher risk of developing cancer, a concept

recently

> described in experimental animals (Potter et al., 1994; Salhon et

al.,

> 1994).

>

> PMID: 7855864, UI: 95159153

>