IGenex and Neurotransmitter results, thoughts?

[Guest guest]

IGenex Results:

Whole blood and serum samples were both negative by PCR, neither genomic nor

plasmid B.b DNA detected.

IFA (Immunofluorescence for IgG, IgM, IgA Bb antibodies) was IND at 1:40.

IgM Western Blot is IGenex positive per two major ( " double star " ) bands having

1+ reactivity: bands 34 and 41. All other major and minor bands were -. By CDC

criteria, S is negative as only band 41 and not band 34 is considered diagnostic

(and he would therefore need a second diagnosic band of 23-25, 31, or 39).

IgG Western Blot is IGenex and CDC negative: Major Band 41 is 2+ but no other

major band is reactive. Minor Band 58 is 1 star reactive. It should be noted

this sample was pulled immediately before S's IVIG (i.e. 4 weeks after his

previous IVIG dose). The contribution of residual IVIG cannot be discounted,

then, in the detection of reactivity to bands 41 and 58. IGenex has no analysis

on the possible crossreactivity of 4 week old residual donor IVIG on their IgG

Western Blot results but stated that they have previously received samples from

patients on IVIG therapy.

I think based on the IgM results, which shouldn't be susceptible to

cross-reacting donor IgG, that I should push my Dr for a course of treatment for

lyme. However, the IFA was IND and the IgG wasn't very supportive, either. What

do you all think? I guess I am still dealing with coming to grips with the

reality of the prevalence and transmission of lyme, and the vague presentation

of subclinical infection. My Dr didn't think I should test while on S is on IVIG

and because of S's poor immune response (his overall IgG levels were within

normal, however he failed to respond to 3 of his vaccine series and he has crazy

high IgG and IgM to some foods and yeast, so he obviously has specific issues in

his IgG response). I went against the Dr's recommendation because S's last Zyto

indicated B. b as one of his largest stresses at that moment, and because if I

am going to pursue stem cell this year (go for broke while going broke) I

certainly don't want to do it if he has lyme or a co infection.

Also, if anyone can weigh in on neurotransmitter results (from Neuro Science),

which I also posted at Holistic Heal, please let me know. Can co-infections

drive high levels of stress-induced neurotransmitters? I'm trying to figure out

why 2 years of controlling S's diet and supplements per urine, blood, and

genetic results isn't paying out on balancing neurotransmitters—I must be doing

something wrong. Do I back off BH4 which promotes Serotonin? Here is my post

there:

Anyone have info on how +/+ BHMT 1and (+/- BHMT 8 ) affects the short and long

cut and relationship to neurotransmitter levels? I can't find info on this forum

on BHMT 1, but thought I once saw that it causes the shortcut to be overactive.

So I tried DMG for a while to try to slow it, but neither DMG nor TMG tested

strong (MRT). I've eliminated many supps via MRT and kept certain ones,

including biopterin (Ecological Formulas) which tested strong and is indicated

per full SNP analysis. (we can't get the BH4 anymore) Taurine also tests strong

and he has poor pancreatic function so this is another item in his tailored

compounded supplement, and we do Hydroxy B12/Folinic shots, etc. Either ammonia

isn't an issue or we are doing things right. However, Sawyers neurtransmitters

(Neuro Science Panel 9123) are (with the exception of PEA) ALL elevated well

above optimal range and some above the 97.5% upper end of the reference range.

At least Glutamate and Gaba, while above optimal, are within reference.

Ridiculously high above reference are DOPAC, Seretonin and 5-HIAA, but also

exceeding reference are Norepinephrine, Taurine, and histamine. The urine sample

was 2nd morning active, fasting (no supps) per collection instructions. Still,

the daily taurine supplment may build up or perhaps he utilizes it poorly,

accounting for the high level. What I'm wondering if the biopterin we are giving

him is making his neurotransmitter level worse. Suggestions and any info on BHMT

SNP's or how to balance neurotransmitter levels are very much appreciated. The

suggested supplements from Neuro science are basically already built into his

compounded supplement, which he's been on with tweaking for 2 years.

+/- VDR Fok; MTHFR: C6777T, 3, A1298C; MTRR A66G; MTRR 11; BHMT 8; AHCY: 1, 2,

19; CDS C699T; SHMT C1420T

+/+ MTRR K350A, BHMT 1

I should note, I backed off on Yasko after only a 9 month trial. I just couldn't

maintain giving and keeping track of all the the supps and S's GI became so

irritated that it took precedence in the way I changed treating him.

Thanks!

Becky