Interstitial pneumonia

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Interstitial pneumonia associated with human adjuvant

disease, which developed 30 years after silicone

augmentation mammoplasty

(Interstitial pneumonia associated with human adjuvant

disease, which developed 30 years after silicone

augmentation mammoplasty).

Author: Mijata Y; Okano R; Kuratomi

Address: Department of General Internal Medicine'

Omiya Medical Center' Jichi Medical School. F1p4

Source: Nippon Kyobu Shikkan Gakkai Zasshi,

35:1093-8, 1997 Oct

ABSTRACT: A 51- year-old woman was admitted to our

hospital which exertional dyspnea' swelling and

stiffness in her fingers. Raynaud's phenomenon and

mammary and axillary lymphadenopathy. She had received

silicone augmentation mammoplasty 30 years ago' and

had since noticed bilateral mammary and axillary

lymphadenopathy that was stable in size. In the years

before admittance she had become aware of an

exacerbation of the lymphadenopathy and had begun to

experience exertional dyspnea several months before

admission suggesting connective tissue disease.

Physical examination revealed symmetrical weakness of

the proximal and a differential diagnosis of

polymyosistis or sjorgren's syndrome was made.

Axillary lymph node biopsy findings were consistent

with silicone lumphadenitis. In addition, chest

roentgenogram and HRCT (elevated total cell count and

neutrophil and eosinophil fractions) and

transbronchial lung biopsy specimens (unevenly

distributed alveolitis with fibrosis) indicated

concurrent interstitial pneumonia. The clinical

correlation between exacerbation of silicone

lymphadenopathy and the development of connective

tissue disease with accompanying interstitial

pneumonia strongly suggest human adjuvant disease

(HAD) as the pathogenesis. To our knowledge

interstitial pneumonia associated with HAD is rare.