Prometrium... hummm you like it, right?

[Guest guest]

I'm surprised to discover that I now seem to do ok with Prometrium.

Transdermal P (even 20-30mg) is hell and is not effective with my

uterus, but surprisingly for me the Prometrium (so far) is landing in

my body rather well. It goes to the uterus (stops bleeding) and is

not hitting my brain with a profound neurosteroid effect (Valium coma

brain) and is not blocking my E and suppressing my immune system.

, don't you do well with Prometrium? Anyone else?

Laurel

[Guest guest]

> I go off Estrogel when the bleed starts and stay off it for 6 days or so.>Val> -----Original Message-----> From: rhythmicliving > [mailto:rhythmicliving ]On Behalf Of Laurel> , don't you do well with Prometrium? Anyone else?

I took prometrium 100mg BID from Inhousepharmacy but only for two days. It gave me heartburn so I gave up taking it. The prometrium from Inhousepharmacy might be too strong for me; I'm 5ft tall small figured girl. Is there anyone who takes Inhousepharmacy prometrium without heartburn?

Val, are you doing fine while go off from the E for 6 days? I've tried stop E while I'm having a period, but I get migraine and don't function well without E. I take 2-3 mg estradiol cream twice a day. My doctor doesn't push me to take a break from E every month so I take E without a break. Are you taking the break to have a good period? Do you know about this? I would appreciate if you let me know. I've been on BHRT for almost 3 years.

[Guest guest]

I take the inhousepharmacy generic Prometrium (200 mg once a day) without any problems. I'm 4'10.5".

I go off the estradiol to make sure I have an adequate bleed. Going off estradiol also helps lessen any developing hyperplasia. I use 2.25 mg Estrogel once a day except for the six days I'm off it. After five days or so off it, I start waking up a little hot but nothing serious.

My protocol "feels" right for me but I really need an ultrasound.

, what level of estradiol are you getting with the 4-6 mg of estradiol cream?

Val

-----Original Message-----From: rhythmicliving [mailto:rhythmicliving ]On Behalf Of sarahg909

I took prometrium 100mg BID from Inhousepharmacy but only for two days. It gave me heartburn so I gave up taking it. The prometrium from Inhousepharmacy might be too strong for me; I'm 5ft tall small figured girl. Is there anyone who takes Inhousepharmacy prometrium without heartburn?

Val, are you doing fine while go off from the E for 6 days? I've tried stop E while I'm having a period, but I get migraine and don't function well without E. I take 2-3 mg estradiol cream twice a day. My doctor doesn't push me to take a break from E every month so I take E without a break. Are you taking the break to have a good period? Do you know about this? I would appreciate if you let me know. I've been on BHRT for almost 3 years.

..

[Guest guest]

Consider the possibility that 150 mg of P cream is too much or your E is too low/too long. P brings on my periods - exactly what it is supposed to do. Low E causes me to spot.

I am curious about your E2 level on the E cream. I've always understood that the estradiol molecule is too large to be delivered through a cream except for the new microspheric technology used in Estrasorb.

I think vaginal P is unlikely to be a problem unless the dose is too high. 50 mg vaginally was terrible for me and the effect was cumulative - each month got worse. P is the "make you fat," "make you crave chocolate," "cause insulin resistance hormone." If I didn't have a uterus, I wouldn't touch the stuff.

Val

-----Original Message-----From: rhythmicliving [mailto:rhythmicliving ]On Behalf Of sarahg909

Val,

Thank you for do let me know about. I haven't tested my estradiol level after I switched to the estradiol from triest in December 2006. My last salvia E level while I was taking triest was 26.6 pg/ml, and progesterone level was 514 pg/ml. I am taking estradiol for almost three months now but I am already taking 5mg a day that gives me a little concern. I think why I need more estradiol is something to do with progesterone cream that I've been taking. I now take 150 mg P 13-14 days and it seems not enough because my period comes always early. If I can't take prometrium, the last option for me is to take P vaginally to protect my uterus. I hope I can handle the vaginal use of P.

..

[Guest guest]

I should post late at night. What I meant to say was:

Consider the possibility that 150 mg of P cream is too much/too long, or your E is too low.

Val

-----Original Message-----From: rhythmicliving [mailto:rhythmicliving ]On Behalf Of Valarie

Consider the possibility that 150 mg of P cream is too much or your E is too low/too long. P brings on my periods - exactly what it is supposed to do. Low E causes me to spot.

I am curious about your E2 level on the E cream. I've always understood that the estradiol molecule is too large to be delivered through a cream except for the new microspheric technology used in Estrasorb.

I think vaginal P is unlikely to be a problem unless the dose is too high. 50 mg vaginally was terrible for me and the effect was cumulative - each month got worse. P is the "make you fat," "make you crave chocolate," "cause insulin resistance hormone." If I didn't have a uterus, I wouldn't touch the stuff.

Val

..

[Guest guest]

I was taking 2.4 mg triest for my first year of BHRT and work up to the 2.6 mg to 3.00mg in the second year. My salvia estradiol level 2.6 pg/ml is the result of it. I had no period at all at that time.

I feel just right with 5mg a day of estradiol now I'm taking ,but dose or the delivery method of progesterone that I have a problem with. I want to cut down P cream more but my period starts early every time I tried. I've also noticed that progesterone does cumulate. It's weakens my immune system. I catch a cold very easily during my P cycle and that is very annoying. This may be a sign of too much progesterone cumulating in my body. Since I've started taking an additional of E (only) during my P cycle, I got rid of minor food cravings and leg heaviness but my getting a cold is a problem.

I didn't know that the estradiol molecule is too large to be delivered through a cream. Did you mean E cream release slower than a gel?

I've tried estradiol gel both from MM and Women's International but they both have a faster release than a cream that I have to take them at least 4- 5 times a day. I get allergic reaction in my skin from WI's E gel. They put too much alcohol in it or I am just allergic to alcohol/ethanol.

>> I should post late at night. What I meant to say was:> > Consider the possibility that 150 mg of P cream is too much/too long, or> your E is too low.> > Val> > -----Original Message-----> From: rhythmicliving > [mailto:rhythmicliving ]On Behalf Of Valarie > > > > Consider the possibility that 150 mg of P cream is too much or your E is> too low/too long. P brings on my periods - exactly what it is supposed to> do. Low E causes me to spot.> > I am curious about your E2 level on the E cream. I've always understood> that the estradiol molecule is too large to be delivered through a cream> except for the new microspheric technology used in Estrasorb.> > I think vaginal P is unlikely to be a problem unless the dose is too high.> 50 mg vaginally was terrible for me and the effect was cumulative - each> month got worse. P is the "make you fat," "make you crave chocolate,"> "cause insulin resistance hormone." If I didn't have a uterus, I wouldn't> touch the stuff.> Val> .>

[Guest guest]

I've noticed that women have varying responses to delivery methods.  Some women absorb easily thru their skin and some do not.   I gather that Larriane Gilespie (sp?) says the E molecule is too large to be absorbed thru the skin, but this is not universally agreed upon.   Some women have tighter skin cells than others so indeed their will be women who don't absorb easily (and there will be loads of other reasons too).  I believe that we must always consider that the science and understanding about hormones and BHRT is so new as to make universal statements unwise.   My immune system is easily suppressed with progesterone, especially transdermal P.  I have recently found that Prometrium (oral P) appears to go to my uterus and not hit my brain.  Dr. Vliet has pointed out (Screaming to be Heard) that 10mg of transdermal OP is equal to 100mg or oral P.  I have found that 100 mg of Prometrium is more effective on my uterus (at this time) than 10mg of transdermal P and it doesn't hit my brain as hard.  Please take a look at Dr. Formby's article on Progesterone dominance.  Progesterone will build up in the tissues.  http://rhythmicliving.org/rhythmicliving/Formby_P_dominance.htmlLaurel  On Mar 19, 2007, at 11:24 AM, sarahg909 wrote:I was taking 2.4 mg triest for my first year of BHRT and work up to the 2.6 mg to 3.00mg in the second year. My salvia estradiol level 2.6 pg/ml is the result of it. I had no period at all at that time.I feel just right with 5mg a day of estradiol now I'm taking ,but dose or the delivery method of progesterone that I have a problem with. I want to cut down P cream more but my period starts early every time I tried. I've also noticed that progesterone does cumulate. It's weakens my immune system. I catch a cold very easily during my P cycle and that is very annoying. This may be a sign of too much progesterone cumulating in my body. Since I've started taking an additional of E (only) during my P cycle, I got rid of minor food cravings and leg heaviness but my getting a cold is a problem. I didn't know that the estradiol molecule is too large to be delivered through a cream.  Did you mean E cream release slower than a gel?I've tried estradiol gel both from MM and Women's International but they both have a faster release than a cream that I have to take them at least 4- 5 times a day. I get allergic reaction in my skin from WI's E gel. They put too much alcohol in it or I am just allergic to alcohol/ethanol. click here for our webpage http://rhythmicliving.com/ **The group conversation is informational in nature and is not intended as medical advice.**

[Guest guest]

To clarify, I did not state with certainty that estradiol cannot be delivered through a cream to the dermis. What I said was that that was my understanding. From research that has been posted here, we have learned that .01% estriol cream and 0.3% estradiol cream (hope I have those numbers correct) are not absorbed systemically when applied to the face. Certainly, I have found that estriol cream on my face has no effect on my estradiol levels.

Val

-----Original Message-----From: rhythmicliving [mailto:rhythmicliving ]On Behalf Of Laurel

I've noticed that women have varying responses to delivery methods. Some women absorb easily thru their skin and some do not. I gather that Larriane Gilespie (sp?) says the E molecule is too large to be absorbed thru the skin, but this is not universally agreed upon. Some women have tighter skin cells than others so indeed their will be women who don't absorb easily (and there will be loads of other reasons too).

..

[Guest guest]

Laurel - my doctor said she didn't want to give me Prometrium for

bleeding because she said she had many complaints from women about it.

I did ask her if I could try it. The sublingual P I'm using though

seems to be doing the trick. I just don't know how much bleeding I'm

SUPPOSED to be doing.

>

> I'm surprised to discover that I now seem to do ok with Prometrium.

> Transdermal P (even 20-30mg) is hell and is not effective with my

> uterus, but surprisingly for me the Prometrium (so far) is landing

in

> my body rather well. It goes to the uterus (stops bleeding) and is

> not hitting my brain with a profound neurosteroid effect (Valium

coma

> brain) and is not blocking my E and suppressing my immune system.

>

> , don't you do well with Prometrium? Anyone else?

>

> Laurel

>

[Guest guest]

- if you took prometrium every day, would you NOT bleed?

>

> I think I'm doing well with Prometrium but only a vaginal

ultrasound will

> tell for sure.

>

> Something strange happens with me, however. I take 200 mg

nightly. I'm

> supposed to take it for 10 days/month. After Dose 9, I start the

bleed. If

> I take Day 10, that period is very scant. If I don't take Day 10,

the bleed

> is quite heavy, at least for a couple of days. Haven't figured

that out

> yet.

>

> I go off Estrogel when the bleed starts and stay off it for 6 days

or so.

> It takes about three days for any spotting to end. That's because

it takes

> three days to build a base in my fat.

>

> I used 50 mg vaginal P for three or four months. I gained weight

on that

> and had horrendous overdose symptoms. Sadly, the weight hasn't

left but

> that's the story of my life.

> Val

>

> -----Original Message-----

> From: rhythmicliving

> [mailto:rhythmicliving ]On Behalf Of Laurel

>

>

> , don't you do well with Prometrium? Anyone else?

> .

>

[Guest guest]

The recommended dosing of Prometrium is 100 mg/day or 200 mg for 10 - 12 days/month. My understanding is that taking it every day prevents any build-up, hence stops any bleeding. It would probably take several months to get that regulated. I've never tried it so don't consider me an authority.

I take it cyclically because I can't bear to take it every day.

When I took Provera, I had the choice of 2.5 mg/day or 5 mg for 10 days a month.

Val

-----Original Message-----From: rhythmicliving [mailto:rhythmicliving ]On Behalf Of

- if you took prometrium every day, would you NOT bleed?

..

[Guest guest]

My understanding for many years is that if you take progesterone every day, it will build up in the tissues. Your body naturally takes a break from progesterone, and when we supplement/replace, we should, too. Virginia

[Guest guest]

I know. I guess that's what we have to decide - which is easier to

bear! The bleeding or the pain!

Somehow, though, I just feel that losing that lining is the way to

go. It somehow feels " normal " to bleed. And how can we be certain

that there would be no build-up of any kind that could turn into

something! Ahh - decisions.

>

> The recommended dosing of Prometrium is 100 mg/day or 200 mg for

10 - 12

> days/month. My understanding is that taking it every day prevents

any

> build-up, hence stops any bleeding. It would probably take

several months

> to get that regulated. I've never tried it so don't consider me an

> authority.

>

> I take it cyclically because I can't bear to take it every day.

>

> When I took Provera, I had the choice of 2.5 mg/day or 5 mg for 10

days a

> month.

>

> Val