Re: Sorry about the all caps. new to the group

[Guest guest]

Hi Allan,

I don't have any knowledge of the condition you're writing about, but

just two things off the top of my head is that the healing process (in

the physical sense) is known as IPR - That's Inflammation,

Proliferation, Remodelling. If you imagine getting a skin cut for this

it's probably easier to visualise than replacing a bone, for now at

least. Inflammation is usually the first 24 hours or so which is what

alerts the body that there's a damage control excercise underway.

Proliferation is where all the tissue starts to knit together just to

'hold the fort' and shore things up. This second stage overlaps the

first. Remodelling can go on for months after, which is where it tidies

things up and replaces everything with the proper materials, reduces

scar tissue etc.

It seems to me that DMSO being anti-inflammatory is removing the pain,

and there's something a bit messed up in that IPR process, where the

body is signalling Inflammation for no good reason, as if it's seeing an

invader in the joints, and perhaps by attenuating that you can slow the

progression, but I can't help wondering if it's actually caused by a

pathogen of some kind that gets into a joint? Sounds crazy, but since

the Docs don't know any better I think we have to look outside the scope

of what they're doing. Because it takes so long to progress (I mean

it's not like you can know in a day whether what you're doing is

allowing the bone to repair), it might take a while to find out what's

going on.

Is this condition classed as an auto-immune disease? (sorry, not had

time to read up on it as I'm really overloaded with work). If so I

would consider looking at some enzymes like Lumbrokinase/Serrapeptase

(fibrinolytic/proteolytic). I find myself saying that to people more

and more lately, as I'm seeing a pattern in many diseases that our

customers present with that the immune system just can't get at because

there's some kind of biofilm or mesh/cage that these critters build

around themselves that protects them from the immune system whilst still

being able to pump out toxins, like mycotoxins between the 'cage bars'.

DMSO is also a good penetrant, so perhaps the two could flush something

out. I know we've had customers deal with things like Arthitis in this way.

In terms of supplements, VItamin C is required to build collagen.

Perhaps some of the joint supplements like Glucosamine and Chondroitin

might not be out of the question.

Regards

B

>

> That was the first time i ever posted to a group other than a roll call. I

> was compelled to share my story. If anyone out there is going thru a bad

> time maybe my story will help. We all see our problems as it were the

> heaviest cross to bare. We often forget that it could be far worse. I

> guess

> i needed to vent. I learned a few things in writing my story. Lol first i

> learned not to type in all caps. I found out it meant i was yelling. My

> typing sucks. That was the longest i typed (pecked with one finger} i have

> done in years. Secondly i learned i could have done it from my gmail and

> avoid some spelling and grammar errors. I was not sure of what i was going

> to write. I totally got caught up in the writing and it just poured out

> that way.

> DMSO If nothing else has brought me some time. Doctors seem to rather cut

> and replace than try to heal. Something in my head keeps telling me to

> wait. My simple rational thought is: With all the broken bones i had from

> sports. How come i never needed to replace them? My broken bones healed by

> themselves. Why are my joints any different? Something besides cutting me

> up and making me bionic has to be possible.I am gonna play dodge the

> doctor

> as long as i possibly can. I feel like Banner looking for a cure to

> avoid turning into the Incredible Hulk. The only difference is I am Allan

> trying to find a cure so i dont turn into Steve Austin the Bionic Man. Lol

> yes that is a 70's reference.(Que the Incredible Hulk walking away theme

> music).

> I am glad this group exist. Sharing knowledge is a cure for many ailments.

> Just think..People use to believe the world was flat...

> FREE THOUGHT IS PARAMOUNT TO FREE WILL....

> BE LIONS NOT SHEEP

>

> Thanks for letting me share

> Allan

>

>

[Guest guest]

Avascular necrosis

From Wikipedia, the free encyclopedia

Jump to: navigation<http://en.wikipedia.org/wiki/Avascular_necrosis#mw-head>,

search <http://en.wikipedia.org/wiki/Avascular_necrosis#p-search>

Avascular necrosis*Classification and external

resources*<http://en.wikipedia.org/wiki/File:Head_of_femur_avascular_necrosis.jp\

g>

Femur head <http://en.wikipedia.org/wiki/Femur_head> showing a flap of

cartilage <http://en.wikipedia.org/wiki/Cartilage> (osteochondritis

dissecans) due to avascular necrosis. Specimen from total hip

replacement<http://en.wikipedia.org/wiki/Total_hip_replacement>surgery.

ICD<http://en.wikipedia.org/wiki/International_Statistical_Classification_of_Dis\

eases_and_Related_Health_Problems>

-10

<http://en.wikipedia.org/wiki/ICD-10>M<http://en.wikipedia.org/wiki/ICD-10_Chapt\

er_M>

87

<http://apps.who.int/classifications/icd10/browse/2010/en#/M87>ICD<http://en.wik\

ipedia.org/wiki/International_Statistical_Classification_of_Diseases_and_Related\

_Health_Problems>

-9

<http://en.wikipedia.org/wiki/List_of_ICD-9_codes>733.4<http://www.icd9data.com/\

getICD9Code.ashx?icd9=733.4>

DiseasesDB

<http://en.wikipedia.org/wiki/Diseases_Database>1174<http://www.diseasesdatabase\

..com/ddb1174.htm>

eMedicine

<http://en.wikipedia.org/wiki/EMedicine>med/2924<http://www.emedicine.com/med/to\

pic2924.htm>

MeSH

<http://en.wikipedia.org/wiki/Medical_Subject_Headings>D010020<http://www.nlm.ni\

h.gov/cgi/mesh/2011/MB_cgi?field=uid & term=D010020>

*Avascular necrosis* (also *osteonecrosis*, *bone

infarction*,[1]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-nawazk\

han-0>

*aseptic necrosis*, *ischemic bone

necrosis*,[2]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-DiGiovan\

ni-1>and

*AVN*) is a disease where there is cellular death

(necrosis<http://en.wikipedia.org/wiki/Necrosis>)

of bone components due to interruption of the blood

supply<http://en.wikipedia.org/wiki/Blood_supply>

..[3] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-2> Without

blood, the bone tissue dies and the bone

collapses.[2]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-DiGiovan\

ni-1>If

avascular necrosis involves the bones of a

joint <http://en.wikipedia.org/wiki/Joint>, it often leads to destruction

of the joint articular surfaces (see Osteochondritis

dissecans<http://en.wikipedia.org/wiki/Osteochondritis_dissecans>

).

Contents [hide <http://en.wikipedia.org/wiki/Avascular_necrosis#>]

- 1 Causes <http://en.wikipedia.org/wiki/Avascular_necrosis#Causes>

- 2 Cell death and

repair<http://en.wikipedia.org/wiki/Avascular_necrosis#Cell_death_and_repair>

- 3

Presentation<http://en.wikipedia.org/wiki/Avascular_necrosis#Presentation>

- 4 Diagnosis <http://en.wikipedia.org/wiki/Avascular_necrosis#Diagnosis>

- 5 Treatment <http://en.wikipedia.org/wiki/Avascular_necrosis#Treatment>

- 6 Prognosis <http://en.wikipedia.org/wiki/Avascular_necrosis#Prognosis>

- 7 Notable

cases<http://en.wikipedia.org/wiki/Avascular_necrosis#Notable_cases>

- 8 See also <http://en.wikipedia.org/wiki/Avascular_necrosis#See_also>

- 9 References<http://en.wikipedia.org/wiki/Avascular_necrosis#References>

- 10 External

links<http://en.wikipedia.org/wiki/Avascular_necrosis#External_links>

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=1>

] Causes

There are many theories about what causes avascular necrosis. Proposed risk

factors include, chemotherapy,

alcoholism<http://en.wikipedia.org/wiki/Alcoholism>

,[4] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-3>excessive

steroid <http://en.wikipedia.org/wiki/Glucocorticoid>

use,[5]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-4>post

trauma,

[6]

<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-5>[7]<http://en.wikip\

edia.org/wiki/Avascular_necrosis#cite_note-6>

caisson

disease <http://en.wikipedia.org/wiki/Caisson_disease> (decompression

sickness),[8] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-7>[

9] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-8> vascular

compression,[10]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-9>

hypertension <http://en.wikipedia.org/wiki/Hypertension>,

vasculitis<http://en.wikipedia.org/wiki/Vasculitis>,

arterial embolism <http://en.wikipedia.org/wiki/Arterial_embolism> and

thrombosis <http://en.wikipedia.org/wiki/Thrombosis>, damage from

radiation<http://en.wikipedia.org/wiki/Radiation>,

bisphosphonates <http://en.wikipedia.org/wiki/Bisphosphonates>(particularly the

mandible

<http://en.wikipedia.org/wiki/Human_mandible>),[11]<http://en.wikipedia.org/wiki\

/Avascular_necrosis#cite_note-10>

sickle

cell anaemia

<http://en.wikipedia.org/wiki/Sickle_cell_anaemia>,[12]<http://en.wikipedia.org/\

wiki/Avascular_necrosis#cite_note-11>

Gaucher's

Disease

<http://en.wikipedia.org/wiki/Gaucher%27s_Disease>,[13]<http://en.wikipedia.org/\

wiki/Avascular_necrosis#cite_note-12>and

deep

diving

<http://en.wikipedia.org/wiki/Deep_diving>.[14]<http://en.wikipedia.org/wiki/Ava\

scular_necrosis#cite_note-13>In

some cases it is

idiopathic <http://en.wikipedia.org/wiki/Idiopathic> (no cause is found).[15

] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-day-14> Rheumatoid

arthritis <http://en.wikipedia.org/wiki/Rheumatoid_arthritis> and

lupus<http://en.wikipedia.org/wiki/Lupus>are also common causes of

AVN. Prolonged, repeated exposure to high

pressures (as experienced by commercial and military

divers<http://en.wikipedia.org/wiki/Diver>)

has been linked to AVN, though the relationship is not well-understood.

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=2>

] Cell death and repair

The hematopoietic cells

<http://en.wikipedia.org/wiki/Hematopoietic_cell>are most sensitive to

anoxia <http://en.wikipedia.org/wiki/Anoxia> and are the first to die after

reduction or removal of the blood supply, usually within 12

hours.[1]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-nawazkhan-0>\

Experimental

evidence suggests that bone

cells <http://en.wikipedia.org/wiki/Bone_cell>

(osteocytes<http://en.wikipedia.org/wiki/Osteocytes>,

osteoclasts <http://en.wikipedia.org/wiki/Osteoclasts>,

osteoblasts<http://en.wikipedia.org/wiki/Osteoblasts>etc.) die within

12–48 hours, and that bone

marrow fat cells <http://en.wikipedia.org/wiki/Bone_marrow_fat_cell> die

within 5

days.[1]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-nawazkhan-0>

Upon reperfusion <http://en.wikipedia.org/wiki/Reperfusion>, repair of

ischemic <http://en.wikipedia.org/wiki/Ischemic> bone occurs in 2 phases;

First, there is angiogenesis

<http://en.wikipedia.org/wiki/Angiogenesis>and movement of

undifferentiated mesenchymal

cells <http://en.wikipedia.org/wiki/Mesenchymal_cell> from adjacent living

bone tissue grow into the dead marrow spaces, as well as entry of

macrophages <http://en.wikipedia.org/wiki/Macrophage> that degrade dead

cellular and fat

debris.[1]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-nawazkhan-0\

>Second,

there is cellular

differentiation <http://en.wikipedia.org/wiki/Cellular_differentiation> of

mesenchymal cells into osteoblasts <http://en.wikipedia.org/wiki/Osteoblast>or

fibroblasts

<http://en.wikipedia.org/wiki/Fibroblast>.[1]<http://en.wikipedia.org/wiki/Avasc\

ular_necrosis#cite_note-nawazkhan-0>Under

favorable conditions, the remaining inorganic mineral volume forms a

framework for establishment of new, fully functional bone

tissue.[1]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-nawazkhan-0\

>

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=3>

] Presentation

While it can affect any bone, and half of cases show multiple sites of

damage, avascular necrosis primarily affects the joints at the

shoulder<http://en.wikipedia.org/wiki/Shoulder>,

knee <http://en.wikipedia.org/wiki/Knee>, and

hip<http://en.wikipedia.org/wiki/Hip>.

The classical sites are: head of femur, neck of talus and waist of scaphoid.

Clinical avascular necrosis most commonly affects the ends

(epiphysis<http://en.wikipedia.org/wiki/Epiphysis>)

of long bones such as the femur <http://en.wikipedia.org/wiki/Femur> (the

bone extending from the knee joint to the hip joint). Other common sites

include the humerus <http://en.wikipedia.org/wiki/Humerus> (the bone of the

upper

arm),[16]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-chapman-15>

[17] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-mansat-16>knees,

[18]

<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-17>[19]<http://en.wik\

ipedia.org/wiki/Avascular_necrosis#cite_note-18>shoulders,

[16] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-chapman-15>[

17] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-mansat-16>ankles

and the

jaw

<http://en.wikipedia.org/wiki/Osteonecrosis_of_the_jaw>.[20]<http://en.wikipedia\

..org/wiki/Avascular_necrosis#cite_note-19>The

disease may affect just one bone, more than one bone at the same time,

or more than one bone at different

times.[21]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-nih06-4857-\

20>Avascular

necrosis usually affects people between 30 and 50 years of age;

about 10,000 to 20,000 people develop avascular necrosis of the head of the

femur in the US each year. When it occurs in children at the femoral head,

it is known as Legg-Calvé-Perthes

syndrome<http://en.wikipedia.org/wiki/Legg-Calv%C3%A9-Perthes_syndrome>

..[22] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-21>

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=4>

] Diagnosis

<http://en.wikipedia.org/wiki/File:OCD_Knee_Walter-1.jpg>

<http://en.wikipedia.org/wiki/File:OCD_Knee_Walter-1.jpg>

Front X-ray of right knee of an

adolescent<http://en.wikipedia.org/wiki/Adolescent>(epiphyseal

plates <http://en.wikipedia.org/wiki/Epiphyseal_plate> are open): arrows

point to avascular necrosis and developing osteochondritis dissecans in the

outer medial condyle of

femur<http://en.wikipedia.org/wiki/Medial_condyle_of_femur>

Orthopaedic doctors most often diagnose the disease except when it affects

the jaws <http://en.wikipedia.org/wiki/Osteonecrosis_of_the_jaw>, when it

is usually diagnosed and treated by dental and

maxillofacial<http://en.wikipedia.org/wiki/Maxillofacial>surgeons.

In the early stages, bone

scintigraphy<http://en.wikipedia.org/wiki/Bone_scintigraphy>

[23] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-22>

and MRI<http://en.wikipedia.org/wiki/MRI>

[24] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-23> are the

diagnostic modalities of choice.

X-ray images of avascular necrosis in the early stages usually appear

normal. In later stages it appears relatively more radio-opaque due to the

nearby living bone becoming resorbed secondary to reactive

hyperemia.[1]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-nawazkha\

n-0>The

necrotic bone itself does not show increased radiographic opacity, as

dead bone cannot undergo bone

resorption<http://en.wikipedia.org/wiki/Bone_resorption>which is

carried out by living

osteoclasts

<http://en.wikipedia.org/wiki/Osteoclast>.[1]<http://en.wikipedia.org/wiki/Avasc\

ular_necrosis#cite_note-nawazkhan-0>Late

radiographic signs also include a radiolucency area following the

collapse of subchondral bone

<http://en.wikipedia.org/wiki/Subchondral_bone>(crescent

sign <http://en.wikipedia.org/wiki/Crescent_sign>) and ringed regions of

radiodensity resulting from saponification and calcification of marrow fat

following medullary infarcts.

- <http://en.wikipedia.org/wiki/File:Osteonecrosis_humerus_1.jpg>

Radiography of total avascular necrosis of right humeral head. Woman of

81 years old with diabetes of long evolution.

- <http://en.wikipedia.org/wiki/File:Osteonecrosis_femur_1.jpg>

Radiography of avascular necrosis of left femoral head. Man of 45 years

old with AIDS.

- <http://en.wikipedia.org/wiki/File:Osteonecrosis_femur_2img.jpg>

Nuclear magnetic resonance of avascular necrosis of left femoral head.

Man of 45 years old with AIDS.

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=5>

] Treatment

Avascular necrosis is especially common in the hip joint. A variety of

methods are now used to treat avascular

necrosis,[21]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-nih06-48\

57-20>the

most common being the total

hip replacement <http://en.wikipedia.org/wiki/Total_hip_replacement>, or

THR. However, THRs have a number of downsides including long recovery times

and short life spans. THRs are an effective means of treatment in the

geriatric population, however doctors shy away from using them in younger

patients due to the reasons above. A new, more promising treatment is hip

resurfacing <http://en.wikipedia.org/wiki/Hip_resurfacing> or metal on

metal (MOM) resurfacing. It is a form of a THR, however in this procedure,

only the head of the femur is removed as opposed to a THR in which the

entire neck is removed. MOM resurfacing is still experimental in America

but has been endorsed in Great Britain as an excellent alternative to a

THR. A MOM Resurfacing may not be suitable in all cases of Avascular

Necrosis, its suitability depends on how much damage has occurred to the

femoral head of the patient, bone is always undergoing change or

remodelling.[25]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-Hall-\

24>The

bone is broken down by osteoclasts and rebuilt by osteoblasts.

[25] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-Hall-24>Some

doctors also prescribe

bisphosphonates <http://en.wikipedia.org/wiki/Bisphosphonates> (e.g.

alendronate <http://en.wikipedia.org/wiki/Alendronate>) which reduces the

rate of bone breakdown by osteoclasts, thus preventing collapse

(specifically of the hip) due to

AVN.[26]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-25>

Other treatments include core decompression, where internal bone pressure

is relieved by drilling a hole into the bone, and a living bone chip and an

electrical device to stimulate new vascular growth are implanted; and the

free vascular fibular graft (FVFG), in which a portion of the fibula, along

with its blood supply, is removed and transplanted into the femoral head.[27

] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-26>

Progression of the disease could possibly be halted by transplanting

nucleated cells from bone marrow into avascular necrosis lesions after core

decompression, although much further research is needed to establish this

technique.[28]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-pmid157\

43852-27>

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=6>

] Prognosis

The amount of disability that results from avascular necrosis depends on

what part of the bone is affected, how large an area is involved, and how

effectively the bone rebuilds itself. The process of bone rebuilding takes

place after an injury as well as during normal

growth.[25]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-Hall-24>No\

rmally,

bone continuously breaks down and rebuilds—old bone is reabsorbed

and replaced with new bone. The process keeps the skeleton strong and helps

it to maintain a balance of

minerals.[25]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-Hall-24>\

In

the course of avascular necrosis, however, the healing process is

usually ineffective and the bone tissues break down faster than the body

can repair them. If left untreated, the disease progresses, the bone

collapses,[2]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-DiGiovan\

ni-1>and

the joint surface breaks down,

[15] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-day-14>leading

to pain and arthritis.

[15] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-day-14>

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=7>

] Notable cases

Avascular necrosis cut short the

football<http://en.wikipedia.org/wiki/National_Football_League>and

baseball <http://en.wikipedia.org/wiki/Major_League_Baseball> careers of

star athlete Bo

<http://en.wikipedia.org/wiki/Bo_>.[29]<http://en.wikipedia.org/wiki/Avas\

cular_necrosis#cite_note-28>

In addition to the athletes listed, AVN has affected musicians including Andy

Bell <http://en.wikipedia.org/wiki/Andy_Bell_(singer)> of the

electronica<http://en.wikipedia.org/wiki/Electronica>

/pop <http://en.wikipedia.org/wiki/Pop_music> duo

Erasure<http://en.wikipedia.org/wiki/Erasure>has had the condition and

replaced both hips.

[30] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-guardian-29>

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=8>

] See also

Dysbaric osteonecrosis <http://en.wikipedia.org/wiki/Dysbaric_osteonecrosis>

[etabolizing enzyme genes in Chinese alcoholics with avascular necrosis of

hip joint, pancreatitis and cirrhosis of the

liver " <http://alcalc.oxfordjournals.org/cgi/content/full/38/5/431?view=long & pmid\

=12915519>(Free

full text).

*Alcohol and alcoholism (Oxford, Oxfordshire)* *38* (5): 431–436.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

:10.1093/alcalc/agg106 <http://dx.doi.org/10.1093%2Falcalc%2Fagg106>.

ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

0735-0414 <http://www.worldcat.org/issn/0735-0414>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

12915519 <http://www.ncbi.nlm.nih.gov/pubmed/12915519>.

http://alcalc.oxfordjournals.org/cgi/content/full/38/5/431?view=long & pmid=129155\

19

..

1. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-4>* Juéry,

P (Mar 2007). " Avascular necrosis after a steroid

injection " <http://www.cmaj.ca/cgi/content/full/176/6/814>(Free full

text).

*Canadian Medical Association

Journal<http://en.wikipedia.org/wiki/Canadian_Medical_Association_Journal>

* *176* (6): 814–814.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

:10.1503/cmaj.1060165 <http://dx.doi.org/10.1503%2Fcmaj.1060165>.

ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

0820-3946 <http://www.worldcat.org/issn/0820-3946>.

PMC<http://en.wikipedia.org/wiki/PubMed_Central>

1808528<http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez & artid=180\

8528>.

PMID <http://en.wikipedia.org/wiki/PubMed_Identifier>

17353545<http://www.ncbi.nlm.nih.gov/pubmed/17353545>.

http://www.cmaj.ca/cgi/content/full/176/6/814.

2. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-5>* Baksi,

Dp (May 1983). " Treatment of post-traumatic avascular necrosis of the

femoral head by multiple drilling and muscle-pedicle bone grafting.

Preliminary report " . *The Journal of bone and joint surgery. British

volume* *65* (3): 268–73.

ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

0301-620X <http://www.worldcat.org/issn/0301-620X>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

6341373 <http://www.ncbi.nlm.nih.gov/pubmed/6341373>.

3. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-6>* Lee,

Ck; Hansen, Hr (Sep 1981). " Post-traumatic avascular necrosis of the

humeral head in displaced proximal humeral fractures " . *The Journal of

trauma* *21* (9): 788–791.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

:10.1097/00005373-198109000-00006<http://dx.doi.org/10.1097%2F00005373-198109000\

-00006>.

ISSN <http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

0022-5282 <http://www.worldcat.org/issn/0022-5282>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

7277543 <http://www.ncbi.nlm.nih.gov/pubmed/7277543>.

4. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-7>* Zhang,

Ld; Kang, Jf; Xue, Hl (Jul 1990). " Distribution of lesions in the head

and neck of the humerus and the femur in dysbaric

osteonecrosis " <http://www.nlm.nih.gov/medlineplus/osteonecrosis.html>(Free

full text).

*Undersea biomedical research* *17* (4): 353–8.

ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

0093-5387 <http://www.worldcat.org/issn/0093-5387>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

2396333 <http://www.ncbi.nlm.nih.gov/pubmed/2396333>.

http://www.nlm.nih.gov/medlineplus/osteonecrosis.html.

5. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-8>*

Lafforgue,

P (Oct 2006). " Pathophysiology and natural history of avascular necrosis of

bone " . *Joint, bone, spine : revue du rhumatisme* *73* (5):

500–507. doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

:10.1016/j.jbspin.2006.01.025<http://dx.doi.org/10.1016%2Fj.jbspin.2006.01.025>.

ISSN <http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

1297-319X <http://www.worldcat.org/issn/1297-319X>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

16931094 <http://www.ncbi.nlm.nih.gov/pubmed/16931094>.

6. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-9>* Laroche,

M (May 2002). " Intraosseous circulation from physiology to disease " . *Joint,

bone, spine : revue du rhumatisme* *69* (3): 262–269.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

:10.1016/S1297-319X(02)00391-3<http://dx.doi.org/10.1016%2FS1297-319X%2802%29003\

91-3>.

ISSN <http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

1297-319X <http://www.worldcat.org/issn/1297-319X>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

12102272 <http://www.ncbi.nlm.nih.gov/pubmed/12102272>.

7. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-10>*

Dannemann,

C; Grätz, Kw; Riener, Mo; Zwahlen, Ra (Apr 2007). " Jaw osteonecrosis

related to bisphosphonate therapy: a severe secondary disorder " . *Bone* *

40* (4): 828–834. doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

:10.1016/j.bone.2006.11.023<http://dx.doi.org/10.1016%2Fj.bone.2006.11.023>.

ISSN <http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

8756-3282 <http://www.worldcat.org/issn/8756-3282>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

17236837 <http://www.ncbi.nlm.nih.gov/pubmed/17236837>.

8. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-11>*

Martí-Carvajal,

A; Dunlop, R; Agreda-, L (Oct 2004). Martí-Carvajal, Arturo J. ed.

" Treatment for avascular necrosis of bone in people with sickle cell

disease " . *Cochrane database of systematic reviews (Online)* (4):

CD004344. doi <http://en.wikipedia.org/wiki/Digital_object_identifier>:

10.1002/14651858.CD004344.pub2<http://dx.doi.org/10.1002%2F14651858.CD004344.pub\

2>.

PMID <http://en.wikipedia.org/wiki/PubMed_Identifier>

15495103<http://www.ncbi.nlm.nih.gov/pubmed/15495103>

.

9. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-12>*

Steinberg,

Marvin E. (March 2008).

" Osteonecrosis " <http://www.merck.com/mmpe/sec04/ch038/ch038a.html>.

*Merck Manual of Diagnosis and

Therapy<http://en.wikipedia.org/wiki/Merck_Manual_of_Diagnosis_and_Therapy>

*. http://www.merck.com/mmpe/sec04/ch038/ch038a.html. Retrieved 25 May

2009.

10. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-13>*

http://www.scuba-diving.org.ua/scubadiving/en/tech.html

11. ^ *a*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-day_14-0>

*b* <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-day_14-1> *

c* <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-day_14-2> Day

S, Ostrum R, Chao E, Rubin C, Aro H, Einhorn T (2000). " Bone injury,

regeneration and repair " . In ph A. Buckwalter, A. Einhorn and

Sheldon R. Simon. *Orthopaedic basic science: biology and biomechanics

of the musculoskeletal system*. Rosemont,

Illinois<http://en.wikipedia.org/wiki/Rosemont,_Illinois>:

American Academy of Orthopaedic

Surgeons<http://en.wikipedia.org/wiki/American_Academy_of_Orthopaedic_Surgeons>.

pp. 372–399.

ISBN<http://en.wikipedia.org/wiki/International_Standard_Book_Number>

0-89203-177-8<http://en.wikipedia.org/wiki/Special:BookSources/0-89203-177-8>.

OCLC <http://en.wikipedia.org/wiki/Online_Computer_Library_Center>

42969533 <http://www.worldcat.org/oclc/42969533>.

12. ^

*a*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-chapman_15-0>

*b*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-chapman_15-1>

Chapman,

C; Mattern, C; Levine, Wn (Nov 2004). " Arthroscopically assisted core

decompression of the proximal humerus for avascular necrosis " . *

Arthroscopy* *20* (9): 1003–1006.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

:10.1016/j.arthro.2004.07.003<http://dx.doi.org/10.1016%2Fj.arthro.2004.07.003>.

ISSN <http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

0749-8063 <http://www.worldcat.org/issn/0749-8063>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

15525936 <http://www.ncbi.nlm.nih.gov/pubmed/15525936>.

13. ^

*a*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-mansat_16-0>

*b*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-mansat_16-1>

Mansat,

P; Huser, L; Mansat, M; Bellumore, Y; Rongières, M; Bonnevialle, P (Mar

2005). " Shoulder arthroplasty for atraumatic avascular necrosis of the

humeral head: nineteen shoulders followed up for a mean of seven years " .

*Journal of Shoulder and Elbow Surgery* *14* (2): 114–120.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

:10.1016/j.jse.2004.06.019<http://dx.doi.org/10.1016%2Fj.jse.2004.06.019>.

ISSN <http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

1058-2746 <http://www.worldcat.org/issn/1058-2746>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

15789002 <http://www.ncbi.nlm.nih.gov/pubmed/15789002>.

14. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-17>*

s,

Ma; Loeb, Pe; Hungerford, Ds (Aug 1989). " Core decompression of the distal

femur for avascular necrosis of the knee " . *The Journal of bone and

joint surgery. British volume* *71* (4): 583–7.

ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

0301-620X <http://www.worldcat.org/issn/0301-620X>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

2768301 <http://www.ncbi.nlm.nih.gov/pubmed/2768301>.

15. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-18>*

Bergman,

Nr; Rand, Ja (Dec 1991). " Total knee arthroplasty in

osteonecrosis " <http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/m\

edia/landingpage.htm?issn=0009-921X & volume=273 & spage=77>(Free

full text).

*Clinical orthopaedics and related research* (273): 77–82.

ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

0009-921X <http://www.worldcat.org/issn/0009-921X>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

1959290 <http://www.ncbi.nlm.nih.gov/pubmed/1959290>.

http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpag\

e.htm?issn=0009-921X & volume=273 & spage=77

.

16. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-19>*

Baykul,

T; Aydin, Ma; Nasir, S (Nov 2004). " Avascular necrosis of the mandibular

condyle causing fibrous ankylosis of the temporomandibular joint in sickle

cell anemia " . *The Journal of craniofacial surgery* *15* (6): 1052–1056.

doi <http://en.wikipedia.org/wiki/Digital_object_identifier>:

10.1097/00001665-200411000-00035<http://dx.doi.org/10.1097%2F00001665-200411000-\

00035>.

ISSN <http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

1049-2275 <http://www.worldcat.org/issn/1049-2275>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

15547404 <http://www.ncbi.nlm.nih.gov/pubmed/15547404>.

17. ^

*a*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-nih06-4857_20-0>

*b*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-nih06-4857_20-1>

National

Institute of Arthritis and Musculoskeletal and Skin

Diseases<http://en.wikipedia.org/wiki/National_Institute_of_Arthritis_and_Muscul\

oskeletal_and_Skin_Diseases>(March

2006).

" Osteonecrosis " <http://www.niams.nih.gov/Health_Info/Osteonecrosis/default.asp>.

Food and Drug

Administration<http://en.wikipedia.org/wiki/Food_and_Drug_Administration_(United\

_States)>.

http://www.niams.nih.gov/Health_Info/Osteonecrosis/default.asp.

Retrieved 25 May 2009.

18. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-21>* Gross,

Gw; Articolo, Ga; Bowen, Jr (1999). " Legg-Calve-Perthes Disease: Imaging

Evaluation and Management " . *Seminars in musculoskeletal radiology*

*3*(4): 379–390.

doi <http://en.wikipedia.org/wiki/Digital_object_identifier>:

10.1055/s-2008-1080081

<http://dx.doi.org/10.1055%2Fs-2008-1080081>.

ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

1089-7860 <http://www.worldcat.org/issn/1089-7860>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

11388931 <http://www.ncbi.nlm.nih.gov/pubmed/11388931>.

19. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-22>*

Maillefert,

Jf; Toubeau, M; Piroth, C; Piroth, L; Brunotte, F; Tavernier, C (Jun 1997).

" Bone scintigraphy equipped with a pinhole collimator for diagnosis of

avascular necrosis of the femoral head " . *Clinical rheumatology*

*16*(4): 372–377.

doi <http://en.wikipedia.org/wiki/Digital_object_identifier>:

10.1007/BF02242454 <http://dx.doi.org/10.1007%2FBF02242454>.

ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

0770-3198 <http://www.worldcat.org/issn/0770-3198>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

9259251 <http://www.ncbi.nlm.nih.gov/pubmed/9259251>.

20. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-23>*

Bluemke,

Da; Zerhouni, Ea (Aug 1996). " MRI of avascular necrosis of bone " . *Topics

in magnetic resonance imaging : TMRI* *8* (4): 231–46.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

:10.1097/00002142-199608000-00003<http://dx.doi.org/10.1097%2F00002142-199608000\

-00003>.

ISSN <http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

0899-3459 <http://www.worldcat.org/issn/0899-3459>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

8870181 <http://www.ncbi.nlm.nih.gov/pubmed/8870181>.

21. ^ *a*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-Hall_24-0>

*b* <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-Hall_24-1>

*c* <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-Hall_24-2>

*d* <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-Hall_24-3>Hall,

B., The Osteoblast and Osteocyte. Vol. 1. 1990: The Telford Press.

494.

22. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-25>*

Agarwala,

S; Jain, D; Joshi, Vr; Sule, A (Mar 2005). " Efficacy of alendronate, a

bisphosphonate, in the treatment of AVN of the hip. A prospective

open-label

study " <http://rheumatology.oxfordjournals.org/cgi/content/full/44/3/352?view=lon\

g & pmid=15572396>(Free

full text).

*Rheumatology (Oxford, England)* *44* (3): 352–359.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

:10.1093/rheumatology/keh481<http://dx.doi.org/10.1093%2Frheumatology%2Fkeh481>.

ISSN <http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

1462-0324 <http://www.worldcat.org/issn/1462-0324>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

15572396 <http://www.ncbi.nlm.nih.gov/pubmed/15572396>.

http://rheumatology.oxfordjournals.org/cgi/content/full/44/3/352?view=long & pmid=\

15572396

.

23. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-26>* Judet,

H; Gilbert, A (May 2001). " Long-term results of free vascularized

fibular grafting for femoral head

necrosis " <http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/\

landingpage.htm?issn=0009-921X & volume=386 & spage=114>(Free

full text).

*Clinical orthopaedics and related research* (386): 114–9.

ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

0009-921X <http://www.worldcat.org/issn/0009-921X>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

11347824 <http://www.ncbi.nlm.nih.gov/pubmed/11347824>.

http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpag\

e.htm?issn=0009-921X & volume=386 & spage=114

.

24.

*^<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-pmid15743852_27-0>

* Gangji V, Hauzeur JP (March 2005). " Treatment of osteonecrosis of the

femoral head with implantation of autologous bone-marrow cells. Surgical

technique " <http://www.ejbjs.org/cgi/content/full/87/1_suppl_1/106>. *J

Bone Joint Surg Am* *87 Suppl 1* (Pt 1): 106–112.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

:10.2106/JBJS.D.02662 <http://dx.doi.org/10.2106%2FJBJS.D.02662>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

15743852 <http://www.ncbi.nlm.nih.gov/pubmed/15743852>.

http://www.ejbjs.org/cgi/content/full/87/1_suppl_1/106.

25. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-28>*

" ESPN.com:

Bo knows stardom and

disappointment " <http://espn.go.com/sportscentury/features/00016045.html>.

http://espn.go.com/sportscentury/features/00016045.html. Retrieved

2007-09-09.

26.

*^<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-guardian_29-0>

* http://www.guardian.co.uk/music/2007/jul/26/popandrock.hiv

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=10>

] External links

- Osteonecrosis / Avascular

Necrosis<http://www.niams.nih.gov/Health_Info/Osteonecrosis/osteonecrosis_ff.asp\

>at

the National

Institute of

Health<http://en.wikipedia.org/wiki/National_Institute_of_Health>

- Osteonecrosis / Avascular

necrosis<http://www.merck.com/mmhe/sec05/ch064/ch064a.html>at Merck

Manual <http://en.wikipedia.org/wiki/Merck_Manual> for patients

- Osteonecrosis / Avascular

necrosis<http://www.merck.com/mmpe/sec04/ch038/ch038a.html>at Merck

Manual <http://en.wikipedia.org/wiki/Merck_Manual> for medical

professionals

- Femoral head avascular

necrosis<http://emedicine.medscape.com/article/86568-overview>at

eMedicine <http://en.wikipedia.org/wiki/EMedicine>

- Center for Osteonecrosis Research <http://www.osteonecrosis.org/>

- National Osteonecrosis Foundation <http://www.nonf.org/>

- Avascular Necrosis Resources <http://www.avnresources.org/>

- Coping with

Osteonecosis<http://www.ourthursday.com/2009/07/16/osteonecrosis-or-avascular-ne\

crois-avn/?q=blog/2009/07/16/osteonecrosis-or-avascular-necrois-avn/>A

real life experience with good links in the comments.

[hide

<http://en.wikipedia.org/wiki/Avascular_necrosis#>]v<http://en.wikipedia.org/wik\

i/Template:Osteochondropathy>

*·* d <http://en.wikipedia.org/wiki/Template_talk:Osteochondropathy>

*·*

e<http://en.wikipedia.org/w/index.php?title=Template:Osteochondropathy & action=ed\

it>

Osteochondropathy <http://en.wikipedia.org/wiki/Osteochondropathy>

(M80–M94<http://en.wikipedia.org/wiki/ICD-10_Chapter_XIII:_Diseases_of_the_muscu\

loskeletal_system_and_connective_tissue#.28M80.E2.80.93M90.29_Osteopathies>,

730–733<http://en.wikipedia.org/wiki/List_of_ICD-9_codes_710%E2%80%93739:_diseas\

es_of_the_musculoskeletal_system_and_connective_tissue#Osteopathies.2C_chondropa\

thies.2C_and_acquired_musculoskeletal_deformities_.28730.E2.80.93739.29>

)Osteopathies <http://en.wikipedia.org/wiki/Bone_disease>

Osteitis <http://en.wikipedia.org/wiki/Osteitis>

*endocrine bone disease<http://en.wikipedia.org/wiki/Endocrine_bone_disease>

:* Osteitis fibrosa

cystica<http://en.wikipedia.org/wiki/Osteitis_fibrosa_cystica>(Brown

tumor <http://en.wikipedia.org/wiki/Brown_tumor>)

*infectious bone disease<http://en.wikipedia.org/wiki/Infectious_bone_disease>

:* Osteomyelitis <http://en.wikipedia.org/wiki/Osteomyelitis>

(Sequestrum<http://en.wikipedia.org/wiki/Sequestrum>,

Involucrum <http://en.wikipedia.org/wiki/Involucrum>)

·Sesamoiditis<http://en.wikipedia.org/wiki/Sesamoiditis>

·Brodie abscess <http://en.wikipedia.org/wiki/Brodie_abscess>

·Periostitis<http://en.wikipedia.org/wiki/Periostitis>

Bone density <http://en.wikipedia.org/wiki/Bone_density>

and structure

Density / metabolic bone

disease<http://en.wikipedia.org/wiki/Metabolic_bone_disease>

Osteoporosis <http://en.wikipedia.org/wiki/Osteoporosis>

(Juvenile<http://en.wikipedia.org/wiki/Juvenile_osteoporosis>)

·Osteopenia <http://en.wikipedia.org/wiki/Osteopenia>

·Osteomalacia<http://en.wikipedia.org/wiki/Osteomalacia>

Continuity of bone

Pseudarthrosis <http://en.wikipedia.org/wiki/Pseudarthrosis> ·Stress

fracture <http://en.wikipedia.org/wiki/Stress_fracture>

Other

Fibrous dysplasia <http://en.wikipedia.org/wiki/Fibrous_dysplasia_of_bone> (

Monostotic <http://en.wikipedia.org/wiki/Monostotic_fibrous_dysplasia>,

Polyostotic <http://en.wikipedia.org/wiki/Polyostotic_fibrous_dysplasia>)

·Skeletal

fluorosis <http://en.wikipedia.org/wiki/Skeletal_fluorosis> ·*bone

cyst<http://en.wikipedia.org/wiki/Bone_cyst>

* (Aneurysmal bone cyst <http://en.wikipedia.org/wiki/Aneurysmal_bone_cyst>)

·Hyperostosis <http://en.wikipedia.org/wiki/Hyperostosis> (Infantile

cortical

hyperostosis<http://en.wikipedia.org/wiki/Infantile_cortical_hyperostosis>)

·Osteosclerosis <http://en.wikipedia.org/wiki/Osteosclerosis> (

Melorheostosis <http://en.wikipedia.org/wiki/Melorheostosis>)

Bone resorption <http://en.wikipedia.org/wiki/Bone_resorption>

Osteolysis <http://en.wikipedia.org/wiki/Osteolysis> ·Hajdu-Cheney

syndrome<http://en.wikipedia.org/wiki/Hajdu%E2%80%93Cheney_syndrome>

·Ainhum <http://en.wikipedia.org/wiki/Ainhum>

Ischemia <http://en.wikipedia.org/wiki/Ischemia>

*Avascular necrosis* (Osteonecrosis of the

jaw<http://en.wikipedia.org/wiki/Osteonecrosis_of_the_jaw>

)

Other

Paget's disease of bone<http://en.wikipedia.org/wiki/Paget%27s_disease_of_bone>

·Algoneurodystrophy<http://en.wikipedia.org/wiki/Complex_regional_pain_syndrome>

·Hypertrophic pulmonary

osteoarthropathy<http://en.wikipedia.org/wiki/Hypertrophic_pulmonary_osteoarthro\

pathy>

·Nonossifying fibroma <http://en.wikipedia.org/wiki/Nonossifying_fibroma>

Chondropathies <http://en.wikipedia.org/wiki/Chondropathy>

Chondritis <http://en.wikipedia.org/wiki/Chondritis>

Relapsing polychondritis<http://en.wikipedia.org/wiki/Relapsing_polychondritis>

Other

Tietze's syndrome <http://en.wikipedia.org/wiki/Tietze_syndrome>

Both

Osteochondritis <http://en.wikipedia.org/wiki/Osteochondritis>

Osteochondritis

dissecans<http://en.wikipedia.org/wiki/Osteochondritis_dissecans>

Juvenile osteochondrosis <http://en.wikipedia.org/wiki/Osteochondrosis>

*lower limb <http://en.wikipedia.org/wiki/Lower_limb>:*

*hip<http://en.wikipedia.org/wiki/Hip>

* (Legg–Calvé–Perthes

syndrome<http://en.wikipedia.org/wiki/Legg%E2%80%93Calv%C3%A9%E2%80%93Perthes_sy\

ndrome>)

·*tibia <http://en.wikipedia.org/wiki/Tibia>* (Osgood-Schlatter

disease<http://en.wikipedia.org/wiki/Osgood%E2%80%93Schlatter_disease>,

Blount's disease <http://en.wikipedia.org/wiki/Blount%27s_disease>)

·*foot<http://en.wikipedia.org/wiki/Foot>

* (Köhler disease <http://en.wikipedia.org/wiki/K%C3%B6hler_disease>, Sever's

disease <http://en.wikipedia.org/wiki/Sever%27s_disease>)

*upper limb <http://en.wikipedia.org/wiki/Upper_limb>:*

*wrist<http://en.wikipedia.org/wiki/Wrist>

* (Kienbock's disease <http://en.wikipedia.org/wiki/Kienbock%27s_disease>)

M <http://en.wikipedia.org/wiki/Template:Medicine_navs>:

BON<http://en.wikipedia.org/wiki/Bone>

/CAR <http://en.wikipedia.org/wiki/Cartilage>

anat

<http://en.wikipedia.org/wiki/Template:Bone_and_cartilage>(c<http://en.wikipedia\

..org/wiki/Template:Cranium>

/f

<http://en.wikipedia.org/wiki/Template:Facial_bones>/k<http://en.wikipedia.org/w\

iki/Template:Compound_structures_of_skull>

/f <http://en.wikipedia.org/wiki/Template:Foramina_of_skull>,

u<http://en.wikipedia.org/wiki/Template:Bones_of_upper_extremity>,

t

<http://en.wikipedia.org/wiki/Template:Bones_of_torso>/p<http://en.wikipedia.org\

/wiki/Template:Pelvis>,

l

<http://en.wikipedia.org/wiki/Template:Bones_of_lower_extremity>)/phys<http://en\

..wikipedia.org/wiki/Template:Bone/cartilage_physiology>

/devp<http://en.wikipedia.org/wiki/Template:Embryology_of_bones,_joints,_and_mus\

cles>

/cell<http://en.wikipedia.org/wiki/Template:Human_cell_types_derived_primarily_f\

rom_mesoderm>

noco

<http://en.wikipedia.org/wiki/Template:Osteochondropathy>/cong<http://en.wikiped\

ia.org/wiki/Template:Osteochondrodysplasia>

/tumr<http://en.wikipedia.org/wiki/Template:Osseous_and_chondromatous_tumors>,

sysi<http://en.wikipedia.org/wiki/Template:Nervous_and_musculoskeletal_system_sy\

mptoms_and_signs>

/epon<http://en.wikipedia.org/wiki/Template:Eponymous_medical_signs_for_skeletal\

_system_and_joints>,

injr <http://en.wikipedia.org/wiki/Template:Fractures>

proc<http://en.wikipedia.org/wiki/Template:Bone,_cartilage,_and_joint_procedures\

>,

drug(M5<http://en.wikipedia.org/wiki/Template:Drugs_for_treatment_of_bone_diseas\

es>

)

> **

>

>

> Hi Allan,

>

> I don't have any knowledge of the condition you're writing about, but

> just two things off the top of my head is that the healing process (in

> the physical sense) is known as IPR - That's Inflammation,

> Proliferation, Remodelling. If you imagine getting a skin cut for this

> it's probably easier to visualise than replacing a bone, for now at

> least. Inflammation is usually the first 24 hours or so which is what

> alerts the body that there's a damage control excercise underway.

> Proliferation is where all the tissue starts to knit together just to

> 'hold the fort' and shore things up. This second stage overlaps the

> first. Remodelling can go on for months after, which is where it tidies

> things up and replaces everything with the proper materials, reduces

> scar tissue etc.

>

> It seems to me that DMSO being anti-inflammatory is removing the pain,

> and there's something a bit messed up in that IPR process, where the

> body is signalling Inflammation for no good reason, as if it's seeing an

> invader in the joints, and perhaps by attenuating that you can slow the

> progression, but I can't help wondering if it's actually caused by a

> pathogen of some kind that gets into a joint? Sounds crazy, but since

> the Docs don't know any better I think we have to look outside the scope

> of what they're doing. Because it takes so long to progress (I mean

> it's not like you can know in a day whether what you're doing is

> allowing the bone to repair), it might take a while to find out what's

> going on.

>

> Is this condition classed as an auto-immune disease? (sorry, not had

> time to read up on it as I'm really overloaded with work). If so I

> would consider looking at some enzymes like Lumbrokinase/Serrapeptase

> (fibrinolytic/proteolytic). I find myself saying that to people more

> and more lately, as I'm seeing a pattern in many diseases that our

> customers present with that the immune system just can't get at because

> there's some kind of biofilm or mesh/cage that these critters build

> around themselves that protects them from the immune system whilst still

> being able to pump out toxins, like mycotoxins between the 'cage bars'.

> DMSO is also a good penetrant, so perhaps the two could flush something

> out. I know we've had customers deal with things like Arthitis in this way.

>

> In terms of supplements, VItamin C is required to build collagen.

> Perhaps some of the joint supplements like Glucosamine and Chondroitin

> might not be out of the question.

>

> Regards

> B

>

>

>

> >

> > That was the first time i ever posted to a group other than a roll call.

> I

> > was compelled to share my story. If anyone out there is going thru a bad

> > time maybe my story will help. We all see our problems as it were the

> > heaviest cross to bare. We often forget that it could be far worse. I

> > guess

> > i needed to vent. I learned a few things in writing my story. Lol first i

> > learned not to type in all caps. I found out it meant i was yelling. My

> > typing sucks. That was the longest i typed (pecked with one finger} i

> have

> > done in years. Secondly i learned i could have done it from my gmail and

> > avoid some spelling and grammar errors. I was not sure of what i was

> going

> > to write. I totally got caught up in the writing and it just poured out

> > that way.

> > DMSO If nothing else has brought me some time. Doctors seem to rather cut

> > and replace than try to heal. Something in my head keeps telling me to

> > wait. My simple rational thought is: With all the broken bones i had from

> > sports. How come i never needed to replace them? My broken bones healed

> by

> > themselves. Why are my joints any different? Something besides cutting me

> > up and making me bionic has to be possible.I am gonna play dodge the

> > doctor

> > as long as i possibly can. I feel like Banner looking for a cure to

> > avoid turning into the Incredible Hulk. The only difference is I am Allan

> > trying to find a cure so i dont turn into Steve Austin the Bionic Man.

> Lol

> > yes that is a 70's reference.(Que the Incredible Hulk walking away theme

> > music).

> > I am glad this group exist. Sharing knowledge is a cure for many

> ailments.

> > Just think..People use to believe the world was flat...

> > FREE THOUGHT IS PARAMOUNT TO FREE WILL....

> > BE LIONS NOT SHEEP

> >

> > Thanks for letting me share

> > Allan

> >

> >

[Guest guest]

They say mine is genetic. i dont fall into the other groups drinking

steroids or sickel cell. Had a blood work up with 21 vials pf blood taken.

the say it must be passed down thru my family. i just happen to be super

active and it affected me earlier than anyone else.

Allan

On Wed, Nov 16, 2011 at 6:56 PM, allan coakley wrote:

> Avascular necrosis

> From Wikipedia, the free encyclopedia

> Jump to: navigation<http://en.wikipedia.org/wiki/Avascular_necrosis#mw-head>,

> search <http://en.wikipedia.org/wiki/Avascular_necrosis#p-search>

> Avascular necrosis*Classification and external

resources*<http://en.wikipedia.org/wiki/File:Head_of_femur_avascular_necrosis.jp\

g>

> Femur head <http://en.wikipedia.org/wiki/Femur_head> showing a flap of

> cartilage <http://en.wikipedia.org/wiki/Cartilage> (osteochondritis

> dissecans) due to avascular necrosis. Specimen from total hip

replacement<http://en.wikipedia.org/wiki/Total_hip_replacement>surgery.

>

ICD<http://en.wikipedia.org/wiki/International_Statistical_Classification_of_Dis\

eases_and_Related_Health_Problems>

> -10 <http://en.wikipedia.org/wiki/ICD-10>

M<http://en.wikipedia.org/wiki/ICD-10_Chapter_M>

> 87 <http://apps.who.int/classifications/icd10/browse/2010/en#/M87>

ICD<http://en.wikipedia.org/wiki/International_Statistical_Classification_of_Dis\

eases_and_Related_Health_Problems>

> -9 <http://en.wikipedia.org/wiki/List_of_ICD-9_codes>

733.4<http://www.icd9data.com/getICD9Code.ashx?icd9=733.4>

> DiseasesDB <http://en.wikipedia.org/wiki/Diseases_Database>

1174<http://www.diseasesdatabase.com/ddb1174.htm>

> eMedicine <http://en.wikipedia.org/wiki/EMedicine>

med/2924<http://www.emedicine.com/med/topic2924.htm>

> MeSH <http://en.wikipedia.org/wiki/Medical_Subject_Headings>

D010020<http://www.nlm.nih.gov/cgi/mesh/2011/MB_cgi?field=uid & term=D010020>

>

> *Avascular necrosis* (also *osteonecrosis*, *bone

infarction*,[1]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-nawazk\

han-0>

> *aseptic necrosis*, *ischemic bone

necrosis*,[2]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-DiGiovan\

ni-1>and

> *AVN*) is a disease where there is cellular death

(necrosis<http://en.wikipedia.org/wiki/Necrosis>)

> of bone components due to interruption of the blood

supply<http://en.wikipedia.org/wiki/Blood_supply>

> .[3] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-2>Without

blood, the bone tissue dies and the bone collapses.

> [2]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-DiGiovanni-1>If

avascular necrosis involves the bones of a

> joint <http://en.wikipedia.org/wiki/Joint>, it often leads to destruction

> of the joint articular surfaces (see Osteochondritis

dissecans<http://en.wikipedia.org/wiki/Osteochondritis_dissecans>

> ).

> Contents [hide <http://en.wikipedia.org/wiki/Avascular_necrosis#>]

>

> - 1 Causes <http://en.wikipedia.org/wiki/Avascular_necrosis#Causes>

> - 2 Cell death and

repair<http://en.wikipedia.org/wiki/Avascular_necrosis#Cell_death_and_repair>

> - 3

Presentation<http://en.wikipedia.org/wiki/Avascular_necrosis#Presentation>

> - 4 Diagnosis<http://en.wikipedia.org/wiki/Avascular_necrosis#Diagnosis>

> - 5 Treatment<http://en.wikipedia.org/wiki/Avascular_necrosis#Treatment>

> - 6 Prognosis<http://en.wikipedia.org/wiki/Avascular_necrosis#Prognosis>

> - 7 Notable

cases<http://en.wikipedia.org/wiki/Avascular_necrosis#Notable_cases>

> - 8 See also <http://en.wikipedia.org/wiki/Avascular_necrosis#See_also>

> - 9 References<http://en.wikipedia.org/wiki/Avascular_necrosis#References>

> - 10 External

links<http://en.wikipedia.org/wiki/Avascular_necrosis#External_links>

>

>

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=1>

> ] Causes

>

> There are many theories about what causes avascular necrosis. Proposed

> risk factors include, chemotherapy,

alcoholism<http://en.wikipedia.org/wiki/Alcoholism>

> ,[4] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-3>excessive

> steroid <http://en.wikipedia.org/wiki/Glucocorticoid>

use,[5]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-4>post trauma,

> [6]

<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-5>[7]<http://en.wikip\

edia.org/wiki/Avascular_necrosis#cite_note-6> caisson

> disease <http://en.wikipedia.org/wiki/Caisson_disease> (decompression

> sickness),[8]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-7>

> [9] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-8>vascular

compression,

> [10] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-9>

> hypertension <http://en.wikipedia.org/wiki/Hypertension>,

vasculitis<http://en.wikipedia.org/wiki/Vasculitis>,

> arterial embolism <http://en.wikipedia.org/wiki/Arterial_embolism> and

> thrombosis <http://en.wikipedia.org/wiki/Thrombosis>, damage from

> radiation <http://en.wikipedia.org/wiki/Radiation>,

bisphosphonates<http://en.wikipedia.org/wiki/Bisphosphonates>(particularly the

> mandible

<http://en.wikipedia.org/wiki/Human_mandible>),[11]<http://en.wikipedia.org/wiki\

/Avascular_necrosis#cite_note-10> sickle

> cell anaemia

<http://en.wikipedia.org/wiki/Sickle_cell_anaemia>,[12]<http://en.wikipedia.org/\

wiki/Avascular_necrosis#cite_note-11> Gaucher's

> Disease

<http://en.wikipedia.org/wiki/Gaucher%27s_Disease>,[13]<http://en.wikipedia.org/\

wiki/Avascular_necrosis#cite_note-12>and deep

> diving

<http://en.wikipedia.org/wiki/Deep_diving>.[14]<http://en.wikipedia.org/wiki/Ava\

scular_necrosis#cite_note-13>In some cases it is

> idiopathic <http://en.wikipedia.org/wiki/Idiopathic> (no cause is found).[

> 15] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-day-14>

Rheumatoid

> arthritis <http://en.wikipedia.org/wiki/Rheumatoid_arthritis> and

lupus<http://en.wikipedia.org/wiki/Lupus>are also common causes of AVN.

Prolonged, repeated exposure to high

> pressures (as experienced by commercial and military

divers<http://en.wikipedia.org/wiki/Diver>)

> has been linked to AVN, though the relationship is not well-understood.

>

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=2>

> ] Cell death and repair

>

> The hematopoietic cells <http://en.wikipedia.org/wiki/Hematopoietic_cell>are

most sensitive to

> anoxia <http://en.wikipedia.org/wiki/Anoxia> and are the first to die

> after reduction or removal of the blood supply, usually within 12 hours.[1

> ]

<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-nawazkhan-0>Experimen\

tal evidence suggests that bone

> cells <http://en.wikipedia.org/wiki/Bone_cell>

(osteocytes<http://en.wikipedia.org/wiki/Osteocytes>,

> osteoclasts <http://en.wikipedia.org/wiki/Osteoclasts>,

osteoblasts<http://en.wikipedia.org/wiki/Osteoblasts>etc.) die within 12–48

hours, and that bone

> marrow fat cells <http://en.wikipedia.org/wiki/Bone_marrow_fat_cell> die

> within 5

days.[1]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-nawazkhan-0>

>

> Upon reperfusion <http://en.wikipedia.org/wiki/Reperfusion>, repair of

> ischemic <http://en.wikipedia.org/wiki/Ischemic> bone occurs in 2 phases;

> First, there is angiogenesis <http://en.wikipedia.org/wiki/Angiogenesis>and

movement of undifferentiated mesenchymal

> cells <http://en.wikipedia.org/wiki/Mesenchymal_cell> from adjacent

> living bone tissue grow into the dead marrow spaces, as well as entry of

> macrophages <http://en.wikipedia.org/wiki/Macrophage> that degrade dead

> cellular and fat

debris.[1]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-nawazkhan-0\

>Second, there is cellular

> differentiation <http://en.wikipedia.org/wiki/Cellular_differentiation>of

mesenchymal cells into

> osteoblasts <http://en.wikipedia.org/wiki/Osteoblast> or

fibroblasts<http://en.wikipedia.org/wiki/Fibroblast>

>

..[1]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-nawazkhan-0>Under

favorable conditions, the remaining inorganic mineral volume forms a

> framework for establishment of new, fully functional bone

tissue.[1]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-nawazkhan-0\

>

>

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=3>

> ] Presentation

>

> While it can affect any bone, and half of cases show multiple sites of

> damage, avascular necrosis primarily affects the joints at the

shoulder<http://en.wikipedia.org/wiki/Shoulder>,

> knee <http://en.wikipedia.org/wiki/Knee>, and

hip<http://en.wikipedia.org/wiki/Hip>.

> The classical sites are: head of femur, neck of talus and waist of scaphoid.

>

> Clinical avascular necrosis most commonly affects the ends

(epiphysis<http://en.wikipedia.org/wiki/Epiphysis>)

> of long bones such as the femur <http://en.wikipedia.org/wiki/Femur> (the

> bone extending from the knee joint to the hip joint). Other common sites

> include the humerus <http://en.wikipedia.org/wiki/Humerus> (the bone of

> the upper

arm),[16]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-chapman-15>

> [17]

<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-mansat-16>knees,

> [18]

<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-17>[19]<http://en.wik\

ipedia.org/wiki/Avascular_necrosis#cite_note-18>shoulders,

> [16]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-chapman-15>

> [17]

<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-mansat-16>ankles and

the

> jaw

<http://en.wikipedia.org/wiki/Osteonecrosis_of_the_jaw>.[20]<http://en.wikipedia\

..org/wiki/Avascular_necrosis#cite_note-19>The disease may affect just one bone,

more than one bone at the same time,

> or more than one bone at different

times.[21]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-nih06-4857-\

20>Avascular necrosis usually affects people between 30 and 50 years of age;

> about 10,000 to 20,000 people develop avascular necrosis of the head of the

> femur in the US each year. When it occurs in children at the femoral head,

> it is known as Legg-Calvé-Perthes

syndrome<http://en.wikipedia.org/wiki/Legg-Calv%C3%A9-Perthes_syndrome>

> .[22] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-21>

>

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=4>

> ] Diagnosis

> <http://en.wikipedia.org/wiki/File:OCD_Knee_Walter-1.jpg>

> <http://en.wikipedia.org/wiki/File:OCD_Knee_Walter-1.jpg>

> Front X-ray of right knee of an

adolescent<http://en.wikipedia.org/wiki/Adolescent>(epiphyseal

> plates <http://en.wikipedia.org/wiki/Epiphyseal_plate> are open): arrows

> point to avascular necrosis and developing osteochondritis dissecans in the

> outer medial condyle of

femur<http://en.wikipedia.org/wiki/Medial_condyle_of_femur>

>

> Orthopaedic doctors most often diagnose the disease except when it affects

> the jaws <http://en.wikipedia.org/wiki/Osteonecrosis_of_the_jaw>, when it

> is usually diagnosed and treated by dental and

maxillofacial<http://en.wikipedia.org/wiki/Maxillofacial>surgeons.

>

> In the early stages, bone

scintigraphy<http://en.wikipedia.org/wiki/Bone_scintigraphy>

> [23] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-22> and

> MRI

<http://en.wikipedia.org/wiki/MRI>[24]<http://en.wikipedia.org/wiki/Avascular_ne\

crosis#cite_note-23>are the diagnostic modalities of choice.

>

> X-ray images of avascular necrosis in the early stages usually appear

> normal. In later stages it appears relatively more radio-opaque due to the

> nearby living bone becoming resorbed secondary to reactive

hyperemia.[1]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-nawazkha\

n-0>The necrotic bone itself does not show increased radiographic opacity, as

> dead bone cannot undergo bone

resorption<http://en.wikipedia.org/wiki/Bone_resorption>which is carried out by

living

> osteoclasts

<http://en.wikipedia.org/wiki/Osteoclast>.[1]<http://en.wikipedia.org/wiki/Avasc\

ular_necrosis#cite_note-nawazkhan-0>Late radiographic signs also include a

radiolucency area following the

> collapse of subchondral

bone<http://en.wikipedia.org/wiki/Subchondral_bone>(crescent

> sign <http://en.wikipedia.org/wiki/Crescent_sign>) and ringed regions of

> radiodensity resulting from saponification and calcification of marrow fat

> following medullary infarcts.

>

> - <http://en.wikipedia.org/wiki/File:Osteonecrosis_humerus_1.jpg>

>

> Radiography of total avascular necrosis of right humeral head. Woman

> of 81 years old with diabetes of long evolution.

> - <http://en.wikipedia.org/wiki/File:Osteonecrosis_femur_1.jpg>

>

> Radiography of avascular necrosis of left femoral head. Man of 45

> years old with AIDS.

> - <http://en.wikipedia.org/wiki/File:Osteonecrosis_femur_2img.jpg>

>

> Nuclear magnetic resonance of avascular necrosis of left femoral head.

> Man of 45 years old with AIDS.

>

>

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=5>

> ] Treatment

>

> Avascular necrosis is especially common in the hip joint. A variety of

> methods are now used to treat avascular

necrosis,[21]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-nih06-48\

57-20>the most common being the total

> hip replacement <http://en.wikipedia.org/wiki/Total_hip_replacement>, or

> THR. However, THRs have a number of downsides including long recovery times

> and short life spans. THRs are an effective means of treatment in the

> geriatric population, however doctors shy away from using them in younger

> patients due to the reasons above. A new, more promising treatment is hip

> resurfacing <http://en.wikipedia.org/wiki/Hip_resurfacing> or metal on

> metal (MOM) resurfacing. It is a form of a THR, however in this procedure,

> only the head of the femur is removed as opposed to a THR in which the

> entire neck is removed. MOM resurfacing is still experimental in America

> but has been endorsed in Great Britain as an excellent alternative to a

> THR. A MOM Resurfacing may not be suitable in all cases of Avascular

> Necrosis, its suitability depends on how much damage has occurred to the

> femoral head of the patient, bone is always undergoing change or

>

remodelling.[25]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-Hall-\

24>The bone is broken down by osteoclasts and rebuilt by osteoblasts.

> [25] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-Hall-24>Some

doctors also prescribe

> bisphosphonates <http://en.wikipedia.org/wiki/Bisphosphonates> (e.g.

> alendronate <http://en.wikipedia.org/wiki/Alendronate>) which reduces the

> rate of bone breakdown by osteoclasts, thus preventing collapse

> (specifically of the hip) due to

AVN.[26]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-25>

>

> Other treatments include core decompression, where internal bone pressure

> is relieved by drilling a hole into the bone, and a living bone chip and an

> electrical device to stimulate new vascular growth are implanted; and the

> free vascular fibular graft (FVFG), in which a portion of the fibula, along

> with its blood supply, is removed and transplanted into the femoral head.[

> 27] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-26>

>

> Progression of the disease could possibly be halted by transplanting

> nucleated cells from bone marrow into avascular necrosis lesions after core

> decompression, although much further research is needed to establish this

>

technique.[28]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-pmid157\

43852-27>

>

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=6>

> ] Prognosis

>

> The amount of disability that results from avascular necrosis depends on

> what part of the bone is affected, how large an area is involved, and how

> effectively the bone rebuilds itself. The process of bone rebuilding takes

> place after an injury as well as during normal

growth.[25]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-Hall-24>No\

rmally, bone continuously breaks down and rebuilds—old bone is reabsorbed

> and replaced with new bone. The process keeps the skeleton strong and helps

> it to maintain a balance of

minerals.[25]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-Hall-24>\

In the course of avascular necrosis, however, the healing process is

> usually ineffective and the bone tissues break down faster than the body

> can repair them. If left untreated, the disease progresses, the bone

>

collapses,[2]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-DiGiovan\

ni-1>and the joint surface breaks down,

> [15] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-day-14>leading

to pain and arthritis.

> [15] <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-day-14>

>

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=7>

> ] Notable cases

>

> Avascular necrosis cut short the

football<http://en.wikipedia.org/wiki/National_Football_League>and

> baseball <http://en.wikipedia.org/wiki/Major_League_Baseball> careers of

> star athlete Bo

<http://en.wikipedia.org/wiki/Bo_>.[29]<http://en.wikipedia.org/wiki/Avas\

cular_necrosis#cite_note-28>

>

> In addition to the athletes listed, AVN has affected musicians including Andy

> Bell <http://en.wikipedia.org/wiki/Andy_Bell_(singer)> of the

electronica<http://en.wikipedia.org/wiki/Electronica>

> /pop <http://en.wikipedia.org/wiki/Pop_music> duo

Erasure<http://en.wikipedia.org/wiki/Erasure>has had the condition and replaced

both hips.

> [30]<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_note-guardian-29>

>

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=8>

> ] See also

>

> Dysbaric osteonecrosis<http://en.wikipedia.org/wiki/Dysbaric_osteonecrosis>

> [etabolizing enzyme genes in Chinese alcoholics with avascular necrosis

> of hip joint, pancreatitis and cirrhosis of the

liver " <http://alcalc.oxfordjournals.org/cgi/content/full/38/5/431?view=long & pmid\

=12915519>(Free full text).

> *Alcohol and alcoholism (Oxford, Oxfordshire)* *38* (5): 431–436.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

> :10.1093/alcalc/agg106 <http://dx.doi.org/10.1093%2Falcalc%2Fagg106>.

ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 0735-0414 <http://www.worldcat.org/issn/0735-0414>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 12915519 <http://www.ncbi.nlm.nih.gov/pubmed/12915519>.

>

http://alcalc.oxfordjournals.org/cgi/content/full/38/5/431?view=long & pmid=129155\

19

> .

>

> 1. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-4>* Juéry,

> P (Mar 2007). " Avascular necrosis after a steroid

injection " <http://www.cmaj.ca/cgi/content/full/176/6/814>(Free full text).

> *Canadian Medical Association

Journal<http://en.wikipedia.org/wiki/Canadian_Medical_Association_Journal>

> * *176* (6): 814–814.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

> :10.1503/cmaj.1060165 <http://dx.doi.org/10.1503%2Fcmaj.1060165>.

ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 0820-3946 <http://www.worldcat.org/issn/0820-3946>.

PMC<http://en.wikipedia.org/wiki/PubMed_Central>

>

1808528<http://www.pubmedcentral.gov/articlerender.fcgi?tool=pmcentrez & artid=180\

8528>.

> PMID <http://en.wikipedia.org/wiki/PubMed_Identifier>

17353545<http://www.ncbi.nlm.nih.gov/pubmed/17353545>.

> http://www.cmaj.ca/cgi/content/full/176/6/814.

> 2. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-5>* Baksi,

> Dp (May 1983). " Treatment of post-traumatic avascular necrosis of the

> femoral head by multiple drilling and muscle-pedicle bone grafting.

> Preliminary report " . *The Journal of bone and joint surgery. British

> volume* *65* (3): 268–73.

ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 0301-620X <http://www.worldcat.org/issn/0301-620X>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 6341373 <http://www.ncbi.nlm.nih.gov/pubmed/6341373>.

> 3. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-6>* Lee,

> Ck; Hansen, Hr (Sep 1981). " Post-traumatic avascular necrosis of the

> humeral head in displaced proximal humeral fractures " . *The Journal of

> trauma* *21* (9): 788–791.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

>

:10.1097/00005373-198109000-00006<http://dx.doi.org/10.1097%2F00005373-198109000\

-00006>.

> ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 0022-5282 <http://www.worldcat.org/issn/0022-5282>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 7277543 <http://www.ncbi.nlm.nih.gov/pubmed/7277543>.

> 4. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-7>* Zhang,

> Ld; Kang, Jf; Xue, Hl (Jul 1990). " Distribution of lesions in the head

> and neck of the humerus and the femur in dysbaric

osteonecrosis " <http://www.nlm.nih.gov/medlineplus/osteonecrosis.html>(Free full

text).

> *Undersea biomedical research* *17* (4): 353–8.

ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 0093-5387 <http://www.worldcat.org/issn/0093-5387>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 2396333 <http://www.ncbi.nlm.nih.gov/pubmed/2396333>.

> http://www.nlm.nih.gov/medlineplus/osteonecrosis.html.

> 5. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-8>*

Lafforgue,

> P (Oct 2006). " Pathophysiology and natural history of avascular necrosis of

> bone " . *Joint, bone, spine : revue du rhumatisme* *73* (5): 500–507.

> doi <http://en.wikipedia.org/wiki/Digital_object_identifier>:

>

10.1016/j.jbspin.2006.01.025<http://dx.doi.org/10.1016%2Fj.jbspin.2006.01.025>.

> ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 1297-319X <http://www.worldcat.org/issn/1297-319X>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 16931094 <http://www.ncbi.nlm.nih.gov/pubmed/16931094>.

> 6. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-9>*

Laroche,

> M (May 2002). " Intraosseous circulation from physiology to disease " .

*Joint,

> bone, spine : revue du rhumatisme* *69* (3): 262–269.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

>

:10.1016/S1297-319X(02)00391-3<http://dx.doi.org/10.1016%2FS1297-319X%2802%29003\

91-3>.

> ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 1297-319X <http://www.worldcat.org/issn/1297-319X>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 12102272 <http://www.ncbi.nlm.nih.gov/pubmed/12102272>.

> 7. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-10>*

Dannemann,

> C; Grätz, Kw; Riener, Mo; Zwahlen, Ra (Apr 2007). " Jaw osteonecrosis

> related to bisphosphonate therapy: a severe secondary disorder " . *Bone*

> *40* (4): 828–834.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

>

:10.1016/j.bone.2006.11.023<http://dx.doi.org/10.1016%2Fj.bone.2006.11.023>.

> ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 8756-3282 <http://www.worldcat.org/issn/8756-3282>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 17236837 <http://www.ncbi.nlm.nih.gov/pubmed/17236837>.

> 8. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-11>*

Martí-Carvajal,

> A; Dunlop, R; Agreda-, L (Oct 2004). Martí-Carvajal, Arturo J. ed.

> " Treatment for avascular necrosis of bone in people with sickle cell

> disease " . *Cochrane database of systematic reviews (Online)* (4):

> CD004344. doi <http://en.wikipedia.org/wiki/Digital_object_identifier>:

>

10.1002/14651858.CD004344.pub2<http://dx.doi.org/10.1002%2F14651858.CD004344.pub\

2>.

> PMID <http://en.wikipedia.org/wiki/PubMed_Identifier>

15495103<http://www.ncbi.nlm.nih.gov/pubmed/15495103>

> .

> 9. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-12>*

Steinberg,

> Marvin E. (March 2008).

" Osteonecrosis " <http://www.merck.com/mmpe/sec04/ch038/ch038a.html>.

> *Merck Manual of Diagnosis and

Therapy<http://en.wikipedia.org/wiki/Merck_Manual_of_Diagnosis_and_Therapy>

> *. http://www.merck.com/mmpe/sec04/ch038/ch038a.html. Retrieved 25 May

> 2009.

> 10. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-13>*

> http://www.scuba-diving.org.ua/scubadiving/en/tech.html

> 11. ^

*a*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-day_14-0>

> *b* <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-day_14-1>

> *c* <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-day_14-2> Day

> S, Ostrum R, Chao E, Rubin C, Aro H, Einhorn T (2000). " Bone injury,

> regeneration and repair " . In ph A. Buckwalter, A. Einhorn and

> Sheldon R. Simon. *Orthopaedic basic science: biology and biomechanics

> of the musculoskeletal system*. Rosemont,

Illinois<http://en.wikipedia.org/wiki/Rosemont,_Illinois>:

> American Academy of Orthopaedic

Surgeons<http://en.wikipedia.org/wiki/American_Academy_of_Orthopaedic_Surgeons>.

> pp. 372–399.

ISBN<http://en.wikipedia.org/wiki/International_Standard_Book_Number>

>

0-89203-177-8<http://en.wikipedia.org/wiki/Special:BookSources/0-89203-177-8>.

> OCLC <http://en.wikipedia.org/wiki/Online_Computer_Library_Center>

> 42969533 <http://www.worldcat.org/oclc/42969533>.

> 12. ^

*a*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-chapman_15-0>

> *b*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-chapman_15-1>

Chapman,

> C; Mattern, C; Levine, Wn (Nov 2004). " Arthroscopically assisted core

> decompression of the proximal humerus for avascular necrosis " . *

> Arthroscopy* *20* (9): 1003–1006.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

>

:10.1016/j.arthro.2004.07.003<http://dx.doi.org/10.1016%2Fj.arthro.2004.07.003>.

> ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 0749-8063 <http://www.worldcat.org/issn/0749-8063>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 15525936 <http://www.ncbi.nlm.nih.gov/pubmed/15525936>.

> 13. ^

*a*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-mansat_16-0>

> *b*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-mansat_16-1>

Mansat,

> P; Huser, L; Mansat, M; Bellumore, Y; Rongières, M; Bonnevialle, P (Mar

> 2005). " Shoulder arthroplasty for atraumatic avascular necrosis of the

> humeral head: nineteen shoulders followed up for a mean of seven years " .

> *Journal of Shoulder and Elbow Surgery* *14* (2): 114–120.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

> :10.1016/j.jse.2004.06.019<http://dx.doi.org/10.1016%2Fj.jse.2004.06.019>.

> ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 1058-2746 <http://www.worldcat.org/issn/1058-2746>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 15789002 <http://www.ncbi.nlm.nih.gov/pubmed/15789002>.

> 14. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-17>*

s,

> Ma; Loeb, Pe; Hungerford, Ds (Aug 1989). " Core decompression of the distal

> femur for avascular necrosis of the knee " . *The Journal of bone and

> joint surgery. British volume* *71* (4): 583–7.

ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 0301-620X <http://www.worldcat.org/issn/0301-620X>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 2768301 <http://www.ncbi.nlm.nih.gov/pubmed/2768301>.

> 15. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-18>*

Bergman,

> Nr; Rand, Ja (Dec 1991). " Total knee arthroplasty in

osteonecrosis " <http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/m\

edia/landingpage.htm?issn=0009-921X & volume=273 & spage=77>(Free full text).

> *Clinical orthopaedics and related research* (273): 77–82.

ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 0009-921X <http://www.worldcat.org/issn/0009-921X>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 1959290 <http://www.ncbi.nlm.nih.gov/pubmed/1959290>.

>

http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpag\

e.htm?issn=0009-921X & volume=273 & spage=77

> .

> 16. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-19>*

Baykul,

> T; Aydin, Ma; Nasir, S (Nov 2004). " Avascular necrosis of the mandibular

> condyle causing fibrous ankylosis of the temporomandibular joint in sickle

> cell anemia " . *The Journal of craniofacial surgery* *15* (6):

> 1052–1056. doi <http://en.wikipedia.org/wiki/Digital_object_identifier>

>

:10.1097/00001665-200411000-00035<http://dx.doi.org/10.1097%2F00001665-200411000\

-00035>.

> ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 1049-2275 <http://www.worldcat.org/issn/1049-2275>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 15547404 <http://www.ncbi.nlm.nih.gov/pubmed/15547404>.

> 17. ^

*a*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-nih06-4857_20-0>

>

*b*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-nih06-4857_20-1>

National

> Institute of Arthritis and Musculoskeletal and Skin

Diseases<http://en.wikipedia.org/wiki/National_Institute_of_Arthritis_and_Muscul\

oskeletal_and_Skin_Diseases>(March 2006).

>

" Osteonecrosis " <http://www.niams.nih.gov/Health_Info/Osteonecrosis/default.asp>.

> Food and Drug

Administration<http://en.wikipedia.org/wiki/Food_and_Drug_Administration_(United\

_States)>.

> http://www.niams.nih.gov/Health_Info/Osteonecrosis/default.asp.

> Retrieved 25 May 2009.

> 18. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-21>*

Gross,

> Gw; Articolo, Ga; Bowen, Jr (1999). " Legg-Calve-Perthes Disease: Imaging

> Evaluation and Management " . *Seminars in musculoskeletal radiology* *3*(4):

379–390.

> doi <http://en.wikipedia.org/wiki/Digital_object_identifier>:

> 10.1055/s-2008-1080081 <http://dx.doi.org/10.1055%2Fs-2008-1080081>.

> ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 1089-7860 <http://www.worldcat.org/issn/1089-7860>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 11388931 <http://www.ncbi.nlm.nih.gov/pubmed/11388931>.

> 19. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-22>*

Maillefert,

> Jf; Toubeau, M; Piroth, C; Piroth, L; Brunotte, F; Tavernier, C (Jun 1997).

> " Bone scintigraphy equipped with a pinhole collimator for diagnosis of

> avascular necrosis of the femoral head " . *Clinical rheumatology* *16*(4):

372–377.

> doi <http://en.wikipedia.org/wiki/Digital_object_identifier>:

> 10.1007/BF02242454 <http://dx.doi.org/10.1007%2FBF02242454>.

ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 0770-3198 <http://www.worldcat.org/issn/0770-3198>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 9259251 <http://www.ncbi.nlm.nih.gov/pubmed/9259251>.

> 20. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-23>*

Bluemke,

> Da; Zerhouni, Ea (Aug 1996). " MRI of avascular necrosis of bone " . *Topics

> in magnetic resonance imaging : TMRI* *8* (4): 231–46.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

>

:10.1097/00002142-199608000-00003<http://dx.doi.org/10.1097%2F00002142-199608000\

-00003>.

> ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 0899-3459 <http://www.worldcat.org/issn/0899-3459>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 8870181 <http://www.ncbi.nlm.nih.gov/pubmed/8870181>.

> 21. ^

*a*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-Hall_24-0>

> *b*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-Hall_24-1>

> *c*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-Hall_24-2>

>

*d*<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-Hall_24-3>Hall, B.,

The Osteoblast and Osteocyte. Vol. 1. 1990: The Telford Press.

> 494.

> 22. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-25>*

Agarwala,

> S; Jain, D; Joshi, Vr; Sule, A (Mar 2005). " Efficacy of alendronate, a

> bisphosphonate, in the treatment of AVN of the hip. A prospective

> open-label

study " <http://rheumatology.oxfordjournals.org/cgi/content/full/44/3/352?view=lon\

g & pmid=15572396>(Free full text).

> *Rheumatology (Oxford, England)* *44* (3): 352–359.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

>

:10.1093/rheumatology/keh481<http://dx.doi.org/10.1093%2Frheumatology%2Fkeh481>.

> ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 1462-0324 <http://www.worldcat.org/issn/1462-0324>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 15572396 <http://www.ncbi.nlm.nih.gov/pubmed/15572396>.

>

http://rheumatology.oxfordjournals.org/cgi/content/full/44/3/352?view=long & pmid=\

15572396

> .

> 23. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-26>*

Judet,

> H; Gilbert, A (May 2001). " Long-term results of free vascularized

> fibular grafting for femoral head

necrosis " <http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/\

landingpage.htm?issn=0009-921X & volume=386 & spage=114>(Free full text).

> *Clinical orthopaedics and related research* (386): 114–9.

ISSN<http://en.wikipedia.org/wiki/International_Standard_Serial_Number>

> 0009-921X <http://www.worldcat.org/issn/0009-921X>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 11347824 <http://www.ncbi.nlm.nih.gov/pubmed/11347824>.

>

http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpag\

e.htm?issn=0009-921X & volume=386 & spage=114

> .

> 24.

*^<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-pmid15743852_27-0>

> * Gangji V, Hauzeur JP (March 2005). " Treatment of osteonecrosis of

> the femoral head with implantation of autologous bone-marrow cells.

> Surgical

technique " <http://www.ejbjs.org/cgi/content/full/87/1_suppl_1/106>.

> *J Bone Joint Surg Am* *87 Suppl 1* (Pt 1): 106–112.

doi<http://en.wikipedia.org/wiki/Digital_object_identifier>

> :10.2106/JBJS.D.02662 <http://dx.doi.org/10.2106%2FJBJS.D.02662>.

PMID<http://en.wikipedia.org/wiki/PubMed_Identifier>

> 15743852 <http://www.ncbi.nlm.nih.gov/pubmed/15743852>.

> http://www.ejbjs.org/cgi/content/full/87/1_suppl_1/106.

> 25. *^ <http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-28>*

" ESPN.com:

> Bo knows stardom and

disappointment " <http://espn.go.com/sportscentury/features/00016045.html>.

> http://espn.go.com/sportscentury/features/00016045.html. Retrieved

> 2007-09-09.

> 26.

*^<http://en.wikipedia.org/wiki/Avascular_necrosis#cite_ref-guardian_29-0>

> * http://www.guardian.co.uk/music/2007/jul/26/popandrock.hiv

>

>

[edit<http://en.wikipedia.org/w/index.php?title=Avascular_necrosis & action=edit & s\

ection=10>

> ] External links

>

> - Osteonecrosis / Avascular

Necrosis<http://www.niams.nih.gov/Health_Info/Osteonecrosis/osteonecrosis_ff.asp\

>at the National

> Institute of

Health<http://en.wikipedia.org/wiki/National_Institute_of_Health>

> - Osteonecrosis / Avascular

necrosis<http://www.merck.com/mmhe/sec05/ch064/ch064a.html>at Merck

> Manual <http://en.wikipedia.org/wiki/Merck_Manual> for patients

> - Osteonecrosis / Avascular

necrosis<http://www.merck.com/mmpe/sec04/ch038/ch038a.html>at Merck

> Manual <http://en.wikipedia.org/wiki/Merck_Manual> for medical

> professionals

> - Femoral head avascular

necrosis<http://emedicine.medscape.com/article/86568-overview>at

> eMedicine <http://en.wikipedia.org/wiki/EMedicine>

> - Center for Osteonecrosis Research <http://www.osteonecrosis.org/>

> - National Osteonecrosis Foundation <http://www.nonf.org/>

> - Avascular Necrosis Resources <http://www.avnresources.org/>

> - Coping with

Osteonecosis<http://www.ourthursday.com/2009/07/16/osteonecrosis-or-avascular-ne\

crois-avn/?q=blog/2009/07/16/osteonecrosis-or-avascular-necrois-avn/>A real life

experience with good links in the comments.

>

> [hide

<http://en.wikipedia.org/wiki/Avascular_necrosis#>]v<http://en.wikipedia.org/wik\

i/Template:Osteochondropathy>

> *·* d <http://en.wikipedia.org/wiki/Template_talk:Osteochondropathy> *·*

e<http://en.wikipedia.org/w/index.php?title=Template:Osteochondropathy & action=ed\

it>

> Osteochondropathy <http://en.wikipedia.org/wiki/Osteochondropathy> (

>

M80–M94<http://en.wikipedia.org/wiki/ICD-10_Chapter_XIII:_Diseases_of_the_muscul\

oskeletal_system_and_connective_tissue#.28M80.E2.80.93M90.29_Osteopathies>,

>

730–733<http://en.wikipedia.org/wiki/List_of_ICD-9_codes_710%E2%80%93739:_diseas\

es_of_the_musculoskeletal_system_and_connective_tissue#Osteopathies.2C_chondropa\

thies.2C_and_acquired_musculoskeletal_deformities_.28730.E2.80.93739.29>

> ) Osteopathies <http://en.wikipedia.org/wiki/Bone_disease>

> Osteitis <http://en.wikipedia.org/wiki/Osteitis>

> *endocrine bone disease<http://en.wikipedia.org/wiki/Endocrine_bone_disease>

> :* Osteitis fibrosa

cystica<http://en.wikipedia.org/wiki/Osteitis_fibrosa_cystica>(Brown

> tumor <http://en.wikipedia.org/wiki/Brown_tumor>)

> *infectious bone disease<http://en.wikipedia.org/wiki/Infectious_bone_disease>

> :* Osteomyelitis <http://en.wikipedia.org/wiki/Osteomyelitis>

(Sequestrum<http://en.wikipedia.org/wiki/Sequestrum>,

> Involucrum <http://en.wikipedia.org/wiki/Involucrum>)

·Sesamoiditis<http://en.wikipedia.org/wiki/Sesamoiditis>

> ·Brodie abscess <http://en.wikipedia.org/wiki/Brodie_abscess>

·Periostitis<http://en.wikipedia.org/wiki/Periostitis>

> Bone density <http://en.wikipedia.org/wiki/Bone_density>

> and structure

> Density / metabolic bone

disease<http://en.wikipedia.org/wiki/Metabolic_bone_disease>

> Osteoporosis <http://en.wikipedia.org/wiki/Osteoporosis>

(Juvenile<http://en.wikipedia.org/wiki/Juvenile_osteoporosis>)

> ·Osteopenia <http://en.wikipedia.org/wiki/Osteopenia>

·Osteomalacia<http://en.wikipedia.org/wiki/Osteomalacia>

> Continuity of bone

> Pseudarthrosis <http://en.wikipedia.org/wiki/Pseudarthrosis> ·Stress

> fracture <http://en.wikipedia.org/wiki/Stress_fracture>

> Other

> Fibrous dysplasia <http://en.wikipedia.org/wiki/Fibrous_dysplasia_of_bone>(

> Monostotic <http://en.wikipedia.org/wiki/Monostotic_fibrous_dysplasia>,

> Polyostotic <http://en.wikipedia.org/wiki/Polyostotic_fibrous_dysplasia>)

> ·Skeletal fluorosis <http://en.wikipedia.org/wiki/Skeletal_fluorosis> ·*bone

> cyst <http://en.wikipedia.org/wiki/Bone_cyst>* (Aneurysmal bone

cyst<http://en.wikipedia.org/wiki/Aneurysmal_bone_cyst>)

> ·Hyperostosis <http://en.wikipedia.org/wiki/Hyperostosis> (Infantile

> cortical

hyperostosis<http://en.wikipedia.org/wiki/Infantile_cortical_hyperostosis>)

> ·Osteosclerosis <http://en.wikipedia.org/wiki/Osteosclerosis> (

> Melorheostosis <http://en.wikipedia.org/wiki/Melorheostosis>)

> Bone resorption <http://en.wikipedia.org/wiki/Bone_resorption>

> Osteolysis <http://en.wikipedia.org/wiki/Osteolysis> ·Hajdu-Cheney

> syndrome <http://en.wikipedia.org/wiki/Hajdu%E2%80%93Cheney_syndrome> ·

> Ainhum <http://en.wikipedia.org/wiki/Ainhum>

> Ischemia <http://en.wikipedia.org/wiki/Ischemia>

> *Avascular necrosis* (Osteonecrosis of the

jaw<http://en.wikipedia.org/wiki/Osteonecrosis_of_the_jaw>

> )

> Other

> Paget's disease of

bone<http://en.wikipedia.org/wiki/Paget%27s_disease_of_bone>

>

·Algoneurodystrophy<http://en.wikipedia.org/wiki/Complex_regional_pain_syndrome>

> ·Hypertrophic pulmonary

osteoarthropathy<http://en.wikipedia.org/wiki/Hypertrophic_pulmonary_osteoarthro\

pathy>

> ·Nonossifying fibroma <http://en.wikipedia.org/wiki/Nonossifying_fibroma>

> Chondropathies <http://en.wikipedia.org/wiki/Chondropathy>

> Chondritis <http://en.wikipedia.org/wiki/Chondritis>

> Relapsing

polychondritis<http://en.wikipedia.org/wiki/Relapsing_polychondritis>

> Other

> Tietze's syndrome <http://en.wikipedia.org/wiki/Tietze_syndrome>

> Both

> Osteochondritis <http://en.wikipedia.org/wiki/Osteochondritis>

> Osteochondritis

dissecans<http://en.wikipedia.org/wiki/Osteochondritis_dissecans>

> Juvenile osteochondrosis <http://en.wikipedia.org/wiki/Osteochondrosis>

> *lower limb <http://en.wikipedia.org/wiki/Lower_limb>:*

*hip<http://en.wikipedia.org/wiki/Hip>

> * (Legg–Calvé–Perthes

syndrome<http://en.wikipedia.org/wiki/Legg%E2%80%93Calv%C3%A9%E2%80%93Perthes_sy\

ndrome>)

> ·*tibia <http://en.wikipedia.org/wiki/Tibia>* (Osgood-Schlatter

disease<http://en.wikipedia.org/wiki/Osgood%E2%80%93Schlatter_disease>,

> Blount's disease <http://en.wikipedia.org/wiki/Blount%27s_disease>)

·*foot<http://en.wikipedia.org/wiki/Foot>

> * (Köhler disease <http://en.wikipedia.org/wiki/K%C3%B6hler_disease>, Sever's

> disease <http://en.wikipedia.org/wiki/Sever%27s_disease>)

> *upper limb <http://en.wikipedia.org/wiki/Upper_limb>:*

*wrist<http://en.wikipedia.org/wiki/Wrist>

> * (Kienbock's disease <http://en.wikipedia.org/wiki/Kienbock%27s_disease>)

>

> M <http://en.wikipedia.org/wiki/Template:Medicine_navs>:

BON<http://en.wikipedia.org/wiki/Bone>

> /CAR <http://en.wikipedia.org/wiki/Cartilage>

>

> anat

<http://en.wikipedia.org/wiki/Template:Bone_and_cartilage>(c<http://en.wikipedia\

..org/wiki/Template:Cranium>

> /f

<http://en.wikipedia.org/wiki/Template:Facial_bones>/k<http://en.wikipedia.org/w\

iki/Template:Compound_structures_of_skull>

> /f <http://en.wikipedia.org/wiki/Template:Foramina_of_skull>,

u<http://en.wikipedia.org/wiki/Template:Bones_of_upper_extremity>,

> t

<http://en.wikipedia.org/wiki/Template:Bones_of_torso>/p<http://en.wikipedia.org\

/wiki/Template:Pelvis>,

> l

<http://en.wikipedia.org/wiki/Template:Bones_of_lower_extremity>)/phys<http://en\

..wikipedia.org/wiki/Template:Bone/cartilage_physiology>

>

/devp<http://en.wikipedia.org/wiki/Template:Embryology_of_bones,_joints,_and_mus\

cles>

>

/cell<http://en.wikipedia.org/wiki/Template:Human_cell_types_derived_primarily_f\

rom_mesoderm>

>

> noco

<http://en.wikipedia.org/wiki/Template:Osteochondropathy>/cong<http://en.wikiped\

ia.org/wiki/Template:Osteochondrodysplasia>

> /tumr<http://en.wikipedia.org/wiki/Template:Osseous_and_chondromatous_tumors>,

>

sysi<http://en.wikipedia.org/wiki/Template:Nervous_and_musculoskeletal_system_sy\

mptoms_and_signs>

>

/epon<http://en.wikipedia.org/wiki/Template:Eponymous_medical_signs_for_skeletal\

_system_and_joints>,

> injr <http://en.wikipedia.org/wiki/Template:Fractures>

>

>

proc<http://en.wikipedia.org/wiki/Template:Bone,_cartilage,_and_joint_procedures\

>,

>

drug(M5<http://en.wikipedia.org/wiki/Template:Drugs_for_treatment_of_bone_diseas\

es>

> )

>

>

>

>

>> **

>>

>>

>> Hi Allan,

>>

>> I don't have any knowledge of the condition you're writing about, but

>> just two things off the top of my head is that the healing process (in

>> the physical sense) is known as IPR - That's Inflammation,

>> Proliferation, Remodelling. If you imagine getting a skin cut for this

>> it's probably easier to visualise than replacing a bone, for now at

>> least. Inflammation is usually the first 24 hours or so which is what

>> alerts the body that there's a damage control excercise underway.

>> Proliferation is where all the tissue starts to knit together just to

>> 'hold the fort' and shore things up. This second stage overlaps the

>> first. Remodelling can go on for months after, which is where it tidies

>> things up and replaces everything with the proper materials, reduces

>> scar tissue etc.

>>

>> It seems to me that DMSO being anti-inflammatory is removing the pain,

>> and there's something a bit messed up in that IPR process, where the

>> body is signalling Inflammation for no good reason, as if it's seeing an

>> invader in the joints, and perhaps by attenuating that you can slow the

>> progression, but I can't help wondering if it's actually caused by a

>> pathogen of some kind that gets into a joint? Sounds crazy, but since

>> the Docs don't know any better I think we have to look outside the scope

>> of what they're doing. Because it takes so long to progress (I mean

>> it's not like you can know in a day whether what you're doing is

>> allowing the bone to repair), it might take a while to find out what's

>> going on.

>>

>> Is this condition classed as an auto-immune disease? (sorry, not had

>> time to read up on it as I'm really overloaded with work). If so I

>> would consider looking at some enzymes like Lumbrokinase/Serrapeptase

>> (fibrinolytic/proteolytic). I find myself saying that to people more

>> and more lately, as I'm seeing a pattern in many diseases that our

>> customers present with that the immune system just can't get at because

>> there's some kind of biofilm or mesh/cage that these critters build

>> around themselves that protects them from the immune system whilst still

>> being able to pump out toxins, like mycotoxins between the 'cage bars'.

>> DMSO is also a good penetrant, so perhaps the two could flush something

>> out. I know we've had customers deal with things like Arthitis in this

>> way.

>>

>> In terms of supplements, VItamin C is required to build collagen.

>> Perhaps some of the joint supplements like Glucosamine and Chondroitin

>> might not be out of the question.

>>

>> Regards

>> B

>>

>>

>>

>> >

>> > That was the first time i ever posted to a group other than a roll

>> call. I

>> > was compelled to share my story. If anyone out there is going thru a bad

>> > time maybe my story will help. We all see our problems as it were the

>> > heaviest cross to bare. We often forget that it could be far worse. I

>> > guess

>> > i needed to vent. I learned a few things in writing my story. Lol first

>> i

>> > learned not to type in all caps. I found out it meant i was yelling. My

>> > typing sucks. That was the longest i typed (pecked with one finger} i

>> have

>> > done in years. Secondly i learned i could have done it from my gmail and

>> > avoid some spelling and grammar errors. I was not sure of what i was

>> going

>> > to write. I totally got caught up in the writing and it just poured out

>> > that way.

>> > DMSO If nothing else has brought me some time. Doctors seem to rather

>> cut

>> > and replace than try to heal. Something in my head keeps telling me to

>> > wait. My simple rational thought is: With all the broken bones i had

>> from

>> > sports. How come i never needed to replace them? My broken bones healed

>> by

>> > themselves. Why are my joints any different? Something besides cutting

>> me

>> > up and making me bionic has to be possible.I am gonna play dodge the

>> > doctor

>> > as long as i possibly can. I feel like Banner looking for a cure

>> to

>> > avoid turning into the Incredible Hulk. The only difference is I am

>> Allan

>> > trying to find a cure so i dont turn into Steve Austin the Bionic Man.

>> Lol

>> > yes that is a 70's reference.(Que the Incredible Hulk walking away theme

>> > music).

>> > I am glad this group exist. Sharing knowledge is a cure for many

>> ailments.

>> > Just think..People use to believe the world was flat...

>> > FREE THOUGHT IS PARAMOUNT TO FREE WILL....

>> > BE LIONS NOT SHEEP

>> >

>> > Thanks for letting me share

>> > Allan

>> >

>> >

[Guest guest]

Allan,

I've been using DMSO topically and internally for years and would never

be without it, I trust.

Sunday night, some side effects of a cleansing protocol I used began

evidencing a work and by Monday had produced a gargantuan swelling of my

big toe joint as well as the next 2 toes and half way up the foot to my

ankle. Brought tears to my eyes to move anything and I threw several

kitchen sinks at it. Felt like the time I dropped a bowling ball on it

or the time I got hit there with a sledgehammer. Was violently inflamed

and became moreso. DMSO seemed to do nothing and you know I soaked in

it. Apparently all the antioxidants I took gave my body enough to fight

the infection. The bone rattling fever chills went away when finally the

fever I didn't know I had broke.

I asked for advice on another list and applied a remedy I had not yet

used.............clay. Soaked it in maybe a gallon of warm water with

prolly 2 tablespoons of bentonite clay whisked in. After half an hour my

poor foot had regained so much range of motion and lost the swelling so

much that I put the other foot in just in case there was something there

to be helped. Quit after an hour. All of the benefit was retained so I

added a pretty big smoosh of clay under a socktop (they hold the clay in

place) and a bit less on the ankle that's starting to complain from

walking wierd. At this point...3 days, the color doesn't match the

unaffected foot--still dark red--but there's very little swelling

anyplace. I'll do another clay soak or compress tomorrow and am

continuing Vitamin C every 3-4 hrs.

Please read thru Eaton's pages http://www.eytonsearth.org. When

you're finished, send him a post--he's kind and very approachable. I bet

a few clay baths and you'll be as stunned with the results as you were

when you discovered DMSO--but the clay will pull the stink out, lol.

BTW, does have a yahoo group eytonsearth but

it's not real active. That may mean you get lots of personal attention.

Saralou

>

> That was the first time i ever posted to a group other than a roll call. I

> was compelled to share my story. If anyone out there is going thru a bad

> time maybe my story will help. We all see our problems as it were the

> heaviest cross to bare. We often forget that it could be far worse. I

> guess

> i needed to vent. I learned a few things in writing my story. Lol first i

> learned not to type in all caps. I found out it meant i was yelling. My

> typing sucks. That was the longest i typed (pecked with one finger} i have

> done in years. Secondly i learned i could have done it from my gmail and

> avoid some spelling and grammar errors. I was not sure of what i was going

> to write. I totally got caught up in the writing and it just poured out

> that way.

> DMSO If nothing else has brought me some time. Doctors seem to rather cut

> and replace than try to heal. Something in my head keeps telling me to

> wait. My simple rational thought is: With all the broken bones i had from

> sports. How come i never needed to replace them? My broken bones healed by

> themselves. Why are my joints any different? Something besides cutting me

> up and making me bionic has to be possible.I am gonna play dodge the

> doctor

> as long as i possibly can. I feel like Banner looking for a cure to

> avoid turning into the Incredible Hulk. The only difference is I am Allan

> trying to find a cure so i dont turn into Steve Austin the Bionic Man. Lol

> yes that is a 70's reference.(Que the Incredible Hulk walking away theme

> music).

> I am glad this group exist. Sharing knowledge is a cure for many ailments.

> Just think..People use to believe the world was flat...

> FREE THOUGHT IS PARAMOUNT TO FREE WILL....

> BE LIONS NOT SHEEP

>

> Thanks for letting me share

> Allan

>

>