YASKO.....Limin help?..... :)

[Guest guest]

A plea for help......just two questions.

Limin....from what you have shared with me and what Dr. AY's print out has

indicated, my son is an OVER methylator and I must use methylating supps

sparingly. Dr. AY emphasizes this repeatedly throughout the print out. Recently,

when speaking to a doctor about this panel, they indicated my son is an UNDER

methylator. Hmmm. ??

Dr. Kurt Woeller, D.O. Genetic Analysis Report (Summary Sheet) indicates:

" NOTE: A VDR (+-) and a VDR (++) together with a COMT (+-) can behave like a

COMT (++) = increased sensitivity to methylating supplements, i.e. Methyl B12,

SAMe, DMAE, Theanine, DMG, TMG. Need to watch for propensity for mood swings,

hyperactivity, irritability. "

Limin you explained in post # 10129 (a brilliant post for anyone who wants to

read it, typical of our Goddess Limin) that I must be careful with methylating

supps and this jibes with AY. I've gone over it many times and cannot see what

this doctor was seeing. He can't be an UNDERmethylator can he? Your 10129 post

makes MUCH more sense to me know that I am s-l-o-w-l-y learning the lingo! But I

am far from truly grasping all this.

Also: I believe my son's genetics indicate a LOW viral child and yet I feel he

is heavily burdened from a viral perspective, but am not certain. So those are

my two questions. I know I must soon join the Dr. AY forum but I am too

overwhelmed and just need familiar gal help right now. Thank you. Thank you.

XOXO Suzan

Dr. AY's Comprehensive Methylation Profile: 13 mutations! The descriptions below

are taken from Woeller's Genetic Analysis Report followed by my comments about

my son. Note: reminder: my son is positive for KPU. Result: 21.9

CBS 699T + - Partial defect. Higher risk for ammonia detox issues.

CBS A360A - - No mutation.

(Note: my son has LOW glutathione. LOW cysteine. LOW G6PDH.)

COMT V158M + - Partial defect. Superior mental performance (elevated

dopamine). Mood Swings. Caution with methylating supps.

COMT H62H + -

COMT 61 - -

VDR Bsm/Taq + + Homozygous mutation. MORE sensitive to methyl donor supps.

Helps support COMT in regulating dopamine levels. (He has slightly elevated

dopamine). Uses methyl groups to do this.

VDR Fok + - Plays a role in bile excretion. My son has light stool and

major gallbladder dysfunction.

MAO A R297R + +

ACAT 102 - -

ACE Del 16 + + Deletion Homozygous mutation. Enzyme leads to high

angiotensin II which causes an increase in aldosterone. High aldosterone leads

to increased potassium in urine and increased sodium retention. His labs are

fine in this regard. ????

MTHFR 677T - - Helps convert homocysteine to methionine.

Homocysteine levels are Normal.

MTHFR A1298C + - Can interfere with dopamine/seratonin balance. His dopamine

elevated, slightly, and he has low seratonin, just inside bottom of range.

MTHFR 3 - -

MTR A2756G - - Helps produce methionine from homocysteine.

MTRR A66G - - Regenerates Methyl B12 to facilitate

homocysteine to methionine conversion.

MTRR H595Y + -

MTRR K350A + -

MTRR 415T - -

MTRR S257T - -

MTRR 11 - -

BMHT 1, 2 and 4 + -

BMHT 8 + +

AHCY 1,2 and 19 - -

NOS DD298E + - Partial Defect. Helps in the formation of Nitric Oxide

which has a role in oxidative stress and chemical production. Can affect urea

cycle relating to ammonia detox. He suffers from Multiple Chemical Sensitivity.

Nitric Oxide connection re: Dr. Pall.

SOUX S370S - - No support needed.